Results 31 to 40 of about 95,803 (268)

Microbiota-derived metabolites as drivers of gut-brain communication [PDF]

, 2022
Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders.
Koistinen Ville, Leyrolle Quentin, Layé Sophie, Kärkkäinen Olli, Ahmed Hany, Delzenne Nathalie, Hanhineva Kati   +6 more
core   +1 more source

Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients

Microbiology Spectrum
Multi-drug resistance (MDR) in Shigella continues to pose a significant public health challenge, particularly in developing countries. Recent advances in genomics strengthen the surveillance of MDR-pathogens and antimicrobial resistance (AMR) mediators ...
Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam   +8 more
doaj   +1 more source

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

Nature Communications, 2019
Early life stress has been associated with the occurrence of gastrointestinal diseases later in life, but underlying mechanisms remain poorly understood. Here, Wong et al.
Hoi Leong Xavier Wong, Hong-yan Qin, Siu Wai Tsang, Xiao Zuo, Sijia Che, Chi Fung Willis Chow, Xi Li, Hai-tao Xiao, Ling Zhao, Tao Huang, Cheng Yuan Lin, Hiu Yee Kwan, Tao Yang, Frank M. Longo, Aiping Lyu, Zhao-xiang Bian   +15 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Multidrug-resistant conjugative plasmid carrying mphA confers increased antimicrobial resistance in Shigella

Scientific Reports
Shigellosis remains a common gastrointestinal disease mostly in children 
Asaduzzaman Asad, Israt Jahan, Moriam Akter Munni, Ruma Begum, Morium Akter Mukta, Kazi Saif, Shah Nayeem Faruque, Shoma Hayat, Zhahirul Islam   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The microbiota-gut-brain axis: clinical applications in obesity and type 2 diabetes

Revista de Investigación Clínica, 2022
Recent investigations highlight the importance of the gut microbiota and bacteria-derived metabolites as key components in obesity and metabolic health. The microbiota-gut-brain axis presents promising targets for future obesity treatments and prevention.
Brandy Moser, Megan A. Milligan, Maria C. Dao   +2 more
doaj   +1 more source

Gut-brain axis

, 2022
Crijevno-mozgovna os predstavlja termin za dvosmjernu komunikaciju između središnjeg živčanog sustava i živčanog sustava crijeva koja kontrolira homeostazu gastrointestinalnog trakta i povezuje ga s emocionalnim i kognitivnim područjima mozga.
Bedoić, Edvard, Batičić, Lara, Kučić, Natalia, Detel, Dijana, Grčić, Antonijo, Varljen, Jadranka   +5 more
core   +1 more source

Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication [PDF]

, 2020
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identity of microbiome-derived compounds that mediate gut-brain axis interaction remain elusive.
van der Hooft, Justin J J, Villar, Victor H, Hulme, Heather, Swales, John, Bragg, Ryan A, Komen, Jasper C, Walker, Daniel, Barnes, Stephanie, Strittmatter, Nicole, Brown, Sheila L, Milling, Simon, Meikle, Lynsey M, Dexter, Alex, Kamat, Maya T, Ormsby, Michael J   +14 more
core   +1 more source