Gut microbiota and gut-kidney axis in kidney diseases: therapeutic potential and perspectives of natural products [PDF]
Frontiers in PharmacologyGut microbiota exert core regulatory effects on systemic metabolic homeostasis and immune balance under physiological and pathological conditions. Marked gut dysbiosis occurs during the progression of chronic kidney disease (CKD), characterized by ...
Qianwei Wang +6 more
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The potency of native postbiotics and paraprobiotics in modulating inflammation by affecting the gut–kidney axis [PDF]
Animal Models and Experimental MedicineBackground The gut's impact on kidney health can be observed through its influence on the gut–kidney axis. However, using paraprobiotic and postbiotic agents may improve gut health and kidney function by affecting signaling pathways.
Fatemeh Haririzadeh Jouriani +6 more
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The Gut–Kidney Axis in Chronic Kidney Diseases [PDF]
DiagnosticsThe gut–kidney axis represents the complex interactions between the gut microbiota and kidney, which significantly impact the progression of chronic kidney disease (CKD) and overall patient health.
Kenji Tsuji +6 more
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Gut-Kidney Axis: Unraveling the Role of the Microbiome in Chronic Kidney Disease [PDF]
BiomedicinesChronic kidney disease (CKD), which affects over 850 million individuals globally, is increasingly regarded as a systemic condition in which the gut microbiota represents a key pathogenic node.
Mihai Rusu +4 more
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The role of mitochondria in the gut-kidney axis: implications for kidney health [PDF]
Frontiers in PharmacologyMitochondria, multifunctional organelles that regulate cellular energy metabolism and signaling pathways, play a pivotal role in maintaining the physiological functions of the gut and kidneys, as well as influencing the progression of chronic kidney ...
Qin Hu, Hua Jin, Hua Jin, Lan Hu, Xu Li
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ILC imbalance – a new piece in the gut-kidney axis puzzle [PDF]
Frontiers in ImmunologyBackgroundThe progression of chronic kidney disease (CKD) is closely linked to gut microbiota dysbiosis and the consequent accumulation of harmful microbial metabolites, forming a vicious cycle called “gut-kidney axis.” However, the specific immune ...
Xinyin Liu +4 more
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Precision targeting of gut-kidney axis: mucosal immunomodulation in IgA nephropathy—a perspective [PDF]
Frontiers in MedicineIgA nephropathy (IgAN) is a primary glomerular disease closely linked to mucosal immune dysregulation, involving a complex interplay between intestinal immune homeostasis and renal injury.
Li-hua Sun, Xia-xia Yang
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Targeting the gut‒kidney axis for lupus nephritis treatment: multimechanism regulatory strategies and evidence from Traditional Chinese medicine [PDF]
Chinese MedicineLupus nephritis (LN) treatment remains challenging because of the limited efficacy and substantial side effects of conventional immunosuppressive therapies.
Qingyun Fang +15 more
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A facile polysaccharide hydrogel activates PPARγ via the Gut-Kidney axis to ameliorate chronic kidney disease [PDF]
Journal of NanobiotechnologyChronic Kidney Disease (CKD) features gut microbiota dysbiosis, systemic inflammation, and impaired barrier function. The formation of such a triad of “microbiota-metabolite-barrier” dysregulation underscores the therapeutic potential of a Gut-Kidney ...
Zhuowen Liang +11 more
doaj +2 more sources
Targeting the gut-kidney axis to improve kidney transplantation prognosis: from mechanisms to clinical intervention strategies [PDF]
Renal FailureKidney transplantation is an important treatment for end-stage renal disease, but lifelong immunosuppression is needed to prevent immune rejection, but the immunosuppressive therapy increases the risk of post-transplant complications.
Huanhuan Cao +5 more
doaj +2 more sources