Results 101 to 110 of about 2,666,950 (298)

Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula

Nature Communications
Brain regions that integrate multiple types of information (“convergence zones”) are crucial for the brain to generate coherent experiences and behaviors. The insula, known for its functional diversity, has been hypothesized as a key convergence hub, yet
Mijin Kwon, Ke Bo, Rotem Botvinik-Nezer, Philip A. Kragel, Lukas Van Oudenhove, Tor D. Wager, The Affective Neuroimaging Consortium   +6 more
doaj   +1 more source

Omissions of threat trigger subjective relief and prediction error-like signaling in the human reward and salience systems

eLife
The unexpected absence of danger constitutes a pleasurable event that is critical for the learning of safety. Accumulating evidence points to similarities between the processing of absent threat and the well-established reward prediction error (PE ...
Anne L Willems, Lukas Van Oudenhove, Bram Vervliet   +2 more
doaj   +1 more source

The Gut–Brain–Muscle Axis: Microbial Regulation of Neuromuscular Aging and Cognitive Frailty

Cognitive frailty, characterized by the coexistence of physical frailty and cognitive impairment, has emerged as a major challenge in aging populations and is closely linked to sarcopenia, neurodegeneration, and chronic inflammation.
Nurpudji Astuti Taslim, Jeremy Nicolas Sibarani, Happy Kurnia Permatasari, Ricky Indra Alfaray, Nelly Mayulu, Dian Aruni Kumalawati, Fahrul Nurkolis, Raymond Rubianto Tjandrawinata, Arifa Mustika   +8 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Therapeutic role of gut microbiota in lung injury-related cognitive impairment

Frontiers in Nutrition
Lung injury can lead to specific neurocognitive dysfunction, and the “triple-hit” phenomenon may be the key theoretical mechanism for the progressive impairment of lung injury-related cognitive impairment.
Yanxia Cheng, Guangtao Hu, Lin Deng, Yalan Zan, Xia Chen   +4 more
doaj   +1 more source

Serotonin neuromicrobiology: Psychobiotic modulation of the gut-brain axis for mental health. [PDF]

Ibrain
An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Mandloi N, Aarzoo, Saravanan C, Ram H, Singh BP.   +4 more
europepmc   +2 more sources

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

The gut–brain axis: historical reflections [PDF]

Microbial Ecology in Health and Disease, 2018
The gut-brain axis and the microbiome have recently acquired an important position in explaining a wide range of human behaviours and emotions. Researchers have typically presented developments in understandings of the microbiome as radical and new, offering huge potential for better understandings of our bodies and what it means to be human.
openaire   +2 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Dietary influences on the gut-brain pathways: Mechanisms and therapeutic potential

Human Nutrition & Metabolism
There is emerging evidence that the gut-brain axis can be significantly influenced through a gut friendly diet. Indeed, nutritional neuroscience holds a significant role in managing the gut brain axis and mental health disorders as numerous pathways ...
Aswani Ajay, Supriya Singh Gaur, Jyoti Singh, Rafeeya Shams, Kshirod Kumar Dash, Ayaz Shaikh Mukarram, Bela Kovács   +6 more
doaj   +1 more source