Results 111 to 120 of about 154,180 (306)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila [PDF]

, 2019
The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges.
Bauer, Christin, Cordero, Julia B., Kruspig, Bjorn, Maddocks, Oliver D.K., Murphy, Daniel J., Scopelliti, Alessandro, Vidal, Marcos, Yu, Yachuan, Zhang, Tong   +8 more
core   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Dietary influences on the gut-brain pathways: Mechanisms and therapeutic potential

Human Nutrition & Metabolism
There is emerging evidence that the gut-brain axis can be significantly influenced through a gut friendly diet. Indeed, nutritional neuroscience holds a significant role in managing the gut brain axis and mental health disorders as numerous pathways ...
Aswani Ajay, Supriya Singh Gaur, Jyoti Singh, Rafeeya Shams, Kshirod Kumar Dash, Ayaz Shaikh Mukarram, Bela Kovács   +6 more
doaj   +1 more source

The kynurenine pathway and the brain: challenges, controversies and promises [PDF]

, 2017
Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Gut-Brain Axis, Notch, and Brain Cancer: ‘The Rising Three’

Majalah Biomorfologi
Highlights • The gut-brain axis (GBA) is a bidirectional communication network linking the gastrointestinal tract and the central nervous system (CNS), involving neurons and various signaling molecules such as endocrine, humoral, metabolic, and ...
Gembong Satria Mahardhika, Norina Agatri
doaj   +1 more source

Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report. [PDF]

, 2019
Imaging of the living human brain is a powerful tool to probe the interactions between brain, gut and microbiome in health and in disorders of brain-gut interactions, in particular IBS.
Aziz, Qasim, Borsook, David, Elsenbruch, Sigrid, Kilpatrick, Lisa, Labus, Jennifer, Mayer, Emeran A, Schweinhardt, Petra, Tracey, Irene, Van Oudenhove, Lukas   +8 more
core   +2 more sources

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

, 2017
Due to their antimicrobial properties, silver nanoparticles (AgNPs) are being used in non-edible and edible consumer products. It is not clear though if exposure to these chemicals can exert toxic effects on the host and gut microbiome.
Bivens, Nathan J., Ellersieck, Mark R., Givan, Scott A., Hansen, Sarah A., Hart, Marcia L., Javurek, Angela B., Kannan, Raghuraman, Rosenfeld, Cheryl S., Spollen, William G., Suresh, Dhananjay, Upendran, Anandhi   +10 more
core   +1 more source