Results 241 to 250 of about 154,180 (306)

The Pediatric Microbiota-Gut-Brain Axis: Implications for Neuropsychiatric Development and Intervention. [PDF]

Children (Basel)
Marano G, Sfratta G, Marzo EM, Cozzo G, Abate F, Traversi G, Mazza O, Capristo E, Gaetani E, Mazza M.   +9 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Nardosinone improves levodopa-induced dyskinesia in Parkinsonian rats through the microbiota-gut-brain axis. [PDF]

Sci Rep
Xue J, Liu M, Cao Y, Hao Z, Wang Y, Wang Y, Lu Y, Fan W, Zhang G, Shi J.   +9 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

"Attacking" the Gut-Brain Axis with Psychobiotics: An Umbrella Review of Depressive and Anxiety Symptoms. [PDF]

Pharmaceuticals (Basel)
Sá Filho AS, Souza TB, Martins JLR, Dietz GPH, Fernandes KF, Sá S, Inacio PA, Oliveira-Silva I, Pedrino G, Aprigliano V, Chiappa GR, Fajemiroye JO.   +11 more
europepmc   +1 more source

Bile Acids as Selective Gatekeepers of Dietary Lipid Absorption: Mechanistic Insights and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Their work provides evidence in murine models that the bile acid pool may function as a tunable filter whose selectivity for different fatty acids depends on bile acid concentration and composition. This framework suggests a selective decoupling of the absorption of excessive saturated fatty acids (SFAs) from that of beneficial polyunsaturated
Hao Wang, Yue Yang, Yulong Zhang, Yinling Li, Xuemei Ma, Haitao Wang   +5 more
wiley   +1 more source

Ciprofloxacin-induced microbiota dysbiosis triggers seizure susceptibility through the microbiota-gut-brain axis. [PDF]

Front Immunol
Zou Q, Zhang Y, Zou S, Li Y, Li H, Yang M, Lai H, Niu R, Yang X, Zhou L.   +9 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Health risk analysis of micro-and nanoplastic exposure via the microbiota-gut-brain axis. [PDF]

Front Immunol
Wang X, Yu H, Li J, Han S, Chi Y.
europepmc   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source