Results 81 to 90 of about 1,633,030 (251)

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression [PDF]

Nephrology Dialysis Transplantation, 2011
The fundamental insights into uraemic toxicity have evolved little since publication of the classical monograph by Cushny nearly a century ago [1]. Organic metabolites are still thought to substantially contribute to uremia (albeit urea might not be the culprit), yet evidence unequivocally demonstrating toxicity of any single uraemic constituent is ...
Björn K I, Meijers, Pieter, Evenepoel
openaire   +2 more sources

Gut microbiome reveals the impact of Microcystin-LR on kidney disease progression though gut–kidney axis

The gut-kidney axis plays a crucial role in kidney disease progression, driven by interactions between the gut microbiome and host proteome. This study explores the impact of microcystin-LR (MC-LR), a potent cyanotoxin, on kidney disease progression ...
kongsintaweesuk, S (via Mendeley Data), kongsintaweesuk, suppakrit   +1 more
core   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Linking gut microbiota to cardiovascular disease and hypertension: Lessons from chronic kidney disease. [PDF]

, 2018
peer reviewedBidirectional interactions exist between the kidneys and the gut. These interactions are commonly referred to as the gut-kidney axis. Chronic kidney disease (CKD) leads to disturbances of the gut ecosystem.
Evenepoel, P., Meijers, Bjorn, F. Jouret, Meijers, B., Jouret, F., B. Meijers, P. Evenepoel, Evenepoel, Pieter, Jouret, François   +8 more
core   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Inflammatory Bowel Diseases and Nephropathies: Exploring the Gut–Kidney Axis

Life
Inflammatory bowel disease (IBD) can extend beyond the gastrointestinal tract, affecting extraintestinal organs and significantly increasing morbidity and mortality. Despite early studies revealing kidney involvement in nearly a quarter of patients with IBD, renal manifestations have been notably overlooked. Among these manifestations, nephrolithiasis,
Roberto de Sire, Alessia La Mantia, Livio Bonacci, Anna Testa, Alessia Dalila Guarino, Antonio Rispo, Olga Maria Nardone, Fabiana Castiglione   +7 more
openaire   +4 more sources

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease: A Review of Links and Risks

Clinical and Experimental Gastroenterology, 2021
Amanda Cheung, Aijaz Ahmed Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USACorrespondence: Amanda CheungDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 750 Welch ...
Cheung A, Ahmed A
doaj  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source