Results 81 to 90 of about 2,342,108 (381)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Multidrug-resistant conjugative plasmid carrying mphA confers increased antimicrobial resistance in Shigella

Scientific Reports
Shigellosis remains a common gastrointestinal disease mostly in children 
Asaduzzaman Asad, Israt Jahan, Moriam Akter Munni, Ruma Begum, Morium Akter Mukta, Kazi Saif, Shah Nayeem Faruque, Shoma Hayat, Zhahirul Islam   +8 more
doaj   +1 more source

Trastornos de la interacción cerebro-intestino (trastornos funcionales digestivos): neuromoduladores en la práctica clínica (parte II)

Revista Colombiana de Gastroenterología
Introducción: este artículo continúa la revisión de los neuromoduladores utilizados en la práctica clínica y su papel en el tratamiento de los diferentes trastornos de la interacción cerebro-intestino (TICI), en particular los gástricos, intestinales y ...
David Benigno Páramo Hernández, Luis Fernando Pineda Ovalle, Laura Marcela Moya Valenzuela, Alejandro Concha Mejía, Juan David Páramo Díaz   +4 more
doaj   +1 more source

Vital dye labelling demonstrates a sacral neural crest contribution to the enteric nervous system of chick and mouse embryos [PDF]

, 1991
We have used the vital dye, DiI, to analyze the contribution of sacral neural crest cells to the enteric nervous system in chick and mouse embryos. In order to label premigratory sacral neural crest cells selectively, DiI was injected into the lumen of ...
Bronner-Fraser, Marianne, Burgan, Scott, Fraser, Scott E., Serbedzija, George N.   +3 more
core  

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

Journal of Lipid Research, 2013
Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism.
G. den Besten, K. van Eunen, A. Groen, K. Venema, D. Reijngoud, Barbara M. Bakker   +5 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. [PDF]

, 2019
Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in ...
Arredondo, Juan, Cortopassi, Gino, Crakes, Katti R, Dandekar, Satya, Datta, Sandipan, Fenton, Anne, Gaulke, Christopher A, Giulivi, Cecilia, Grishina, Irina, Hirao, Lauren A, Marco, Maria L, Napoli, Eleonora, Sankaran-Walters, Sumathi, Santos Rocha, Clarissa   +13 more
core  

SARS-CoV-2 productively infects human gut enterocytes

Science, 2020
Intestinal organoids as an infection model Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an influenza-like disease with a respiratory transmission route; however, patients often present with gastrointestinal symptoms such as ...
M. Lamers, J. Beumer, J. van der Vaart, K. Knoops, Jens Puschhof, T. I. Breugem, R. Ravelli, J. P. Van Schayck, A. Mykytyn, H. Duimel, E. V. van Donselaar, Samra Riesebosch, H. Kuijpers, D. Schipper, Willine J. van de Wetering, Miranda de Graaf, M. Koopmans, E. Cuppen, P. Peters, B. Haagmans, H. Clevers   +20 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Altered distribution of mucosal NK cells during HIV infection. [PDF]

, 2012
The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s ...
Alter, G, Berger, CT, Carrington, M, Deeks, SG, Diefenbach, T, Dugast, A-S, Estes, JD, Ghebremichael, M, Hunt, PW, Kwon, D, Liu, Q, Martin, JN, Sciaranghella, G, Sips, M   +13 more
core   +2 more sources