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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases [PDF]

Signal Transduction and Targeted Therapy
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, development ...
Jian Sheng Loh, Wen Qi Mak, Li Tan, Chu Xin Ng, Hong Hao Chan, Shiau Hueh Yeow, Jhi Biau Foo, Yong Sze Ong, Chee Wun How, Kooi Yeong Khaw   +9 more
openalex   +2 more sources

Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice

Gut Microbes, 2022
The gut microbiota was emerging as critical regulatory elements in shaping the outcome of cancer immunotherapy. However, the underlying mechanisms by which the gut commensal species enhance antitumor immunity remain largely unexplored. Here, we show that
Shi-Long Zhang, Bing Han, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, You Wu, Guo-Qiang Chen, Li-Shun Wang   +8 more
doaj   +1 more source

Invasion of intestinal cells by Staphylococcus warneri, a member of the human gut microbiota

Gut Pathogens, 2023
Coagulase negative staphylococci (CoNS) are a heterogeneous group of bacteria that colonize different types of human epithelia. These bacteria have a highly variable pathogenic potential ranging from avirulent species to major nosocomial pathogens ...
Robin Louail, Franklin Florin, Sophie Bernard, Jean-Baptiste Michaud, Jonathan Breton, Najate Achamrah, Marie-Pierre Tavolacci, Moïse Coëffier, David Ribet   +8 more
doaj   +1 more source

Longitudinal Evaluation of Gut Bacteriomes and Viromes after Fecal Microbiota Transplantation for Eradication of Carbapenem-Resistant Enterobacteriaceae

mSystems, 2022
Understanding the role of fecal microbiota transplantation (FMT) in the decolonization of multidrug-resistant organisms (MDRO) is critical. Specifically, little is known about virome changes in MDRO-infected subjects treated with FMT.
Qin Liu, Tao Zuo, Wenqi Lu, Yun Kit Yeoh, Qi Su, Zhilu Xu, Whitney Tang, Keli Yang, Fen Zhang, Louis H. S. Lau, Rashid N. S. Lui, Miu Ling Chin, Rity Wong, Chun Pan Cheung, Wenyi Zhu, Paul K. S. Chan, Francis K. L. Chan, Grace C. Lui, Siew C. Ng   +18 more
doaj   +1 more source

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

Gut, 2021
Objective Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and ...
Yun Kit Yeoh, T. Zuo, G. Lui, Fen Zhang, Qin Liu, A. Li, A. Chung, C. Cheung, E. Tso, K. Fung, Veronica Chan, L. Ling, G. Joynt, D. Hui, K. Chow, S. Ng, Timothy Li, R. Ng, T. Yip, G. Wong, F. K. Chan, C. Wong, P. Chan, S. Ng   +23 more
semanticscholar   +1 more source

Diet contributes to urban-induced alterations in gut microbiota : experimental evidence from a wild passerine [PDF]

, 2020
Urban sprawl increasingly affects the ecology of natural populations, including host-microbiota interactions, with observed differences in the gut microbiota between urban and rural hosts.
De Neve, Liesbeth, Lens, Luc, Matthysen, Erik, Salleh Hudin, Noraine, Teyssier, Aimeric, White, Joël   +5 more
core   +1 more source

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

Frontiers in Endocrinology, 2020
A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions.
Ygor Parladore Silva, A. Bernardi, R. Frozza   +2 more
semanticscholar   +1 more source

A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut

Gut, 2023
Objective Ample evidence exists for the role of abnormal gut microbiota composition and increased gut permeability (‘leaky gut’) in chronic inflammation that commonly co-occurs in the gut in both obesity and diabetes, yet the detailed mechanisms involved
S. Mishra, Bo Wang, Shalini Jain, Jingzhong Ding, Jared J. Rejeski, C. Furdui, D. Kitzman, S. Taraphder, C. Bréchot, Ambuj Kumar, H. Yadav   +10 more
semanticscholar   +1 more source

Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota

Nutrients, 2023
Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis and their deficiency is involved in the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, and ...
W. Fusco, Manuel Bernabeu Lorenzo, M. Cintoni, Serena Porcari, E. Rinninella, Francesco Kaitsas, Elena Lener, M. C. Mele, A. Gasbarrini, M. Collado, G. Cammarota, G. Ianiro   +11 more
semanticscholar   +1 more source

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

BMC Medicine, 2022
Background Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown. Methods A two-sample Mendelian randomization
Pengsheng Li, Haiyan Wang, Lan Guo, Xiaoyan Gou, Geng-dong Chen, Dongxin Lin, D. Fan, Xiaoling Guo, Zheng-ping Liu   +8 more
semanticscholar   +1 more source