Results 1 to 10 of about 266,993 (291)

Gut microbiota dysbiosis in functional gastrointestinal disorders: Underpinning the symptoms and pathophysiology [PDF]

, 2021
Lai Wei, Rajan Singh, Seungil Ro, Uday C. Ghoshal   +3 more
openalex   +1 more source

Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation

Frontiers in Pharmacology
Pulmonary hypertension (PH) is a complex and progressive vascular disease characterized by elevated pulmonary arterial pressure (PAP) and vascular resistance, leading to right ventricular failure and, ultimately, death.
Xue-Xue Zhu, Chen-Yang Zhao, Qing-Bo Lu, Ao-Yuan Zhang, Xin-Yu Meng, Jia-Bao Su, Guo Chen, An-Jing Xu, Hai-Jian Sun, Xiao-Wei Nie   +9 more
doaj   +1 more source

3D‐Printed Gastrointestinal Stents: In Vivo Evaluation in a Swine Small Bowel Perforation Model

Advanced Healthcare Materials, EarlyView.
Gastrointestinal fistulae and perforations can lead to severe complications including sepsis and patient death. In this work, the efficacy of 3D‐printed gastrointestinal stents composed of poly‐lactic‐acid (PLA) was evaluated in an in vivo swine model.
Gweniviere Capron, Parinaz Fathi, Tor Wolf Jensen, Derek J. Milner, André J. van der Vlies, Regan L. Moody, Elizabeth A. Bangert, Blair Rowitz, Dipanjan Pan, Matthew B. Wheeler   +9 more
wiley   +1 more source

Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy

Chinese Medicine
Background Lipid metabolism is crucial in cancer progression. Lipid droplets (LDs) generated in cancer cells can act as protective mechanisms through alleviating lipotoxicity under stress conditions.
Guosheng Wu, Liang Ying, Qian Zhang, He Xiong, Jie Wang, Sitao Chen, Chen Yang, Yiyuan Jin, Zengwei Lai, Ninghan Feng, Yunjun Ge   +10 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice

Nature Communications
Despite decades of studies into the mechanisms underlying acute kidney injury (AKI), the effective clinical therapies are still limited. Here we report that the development of AKI was attenuated by conditional knockout of phosphoglycerate kinase 1 (PGK1)
Xue-Xue Zhu, Xin-Yu Meng, Ao-Yuan Zhang, Chen-Yang Zhao, Yi-Ting Wei, Yuan-Yuan Wen, Jia-Bao Su, Xiao Fu, Guo Chen, An-Jing Xu, Meng-Yuan Wang, Le-Ming Ji, Neng Bao, Zheng-Yang Bao, Na Li, Qing-Bo Lu, Hai-Jian Sun   +16 more
doaj   +1 more source

Disordered Gut Microbiota Correlates With Altered Fecal Bile Acid Metabolism and Post-cholecystectomy Diarrhea

Frontiers in Microbiology, 2022
Post-cholecystectomy diarrhea (PCD) is a common complication of gallbladder removal, and gut microbiota changes have been determined in PCD patients. Bile acid diarrhea (BAD) is supposed to be the main pathogenic factor for PCD due to the disrupted fecal
Yayun Xu, Yayun Xu, Hui Jing, Hui Jing, Jianfa Wang, Jianfa Wang, Shilong Zhang, Qimeng Chang, Qimeng Chang, Zhanming Li, Zhanming Li, Xubo Wu, Xubo Wu, Ziping Zhang, Ziping Zhang   +14 more
doaj   +1 more source

Mucosa‐Interfacing Capsule for In Situ Sensing the Elasticity of Biological Tissues

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A fundamental mechanism of palpating soft materials is reported to sense deep tissue elasticity in situ with minimal invasion using the interaction between the robot palpation unit and soft tissues. Both the robot locomotion and elasticity sensing functions are remotely controlled by external magnetic fields, while the sensing data are wirelessly ...
Kiyoung Kim, Steven Edwards, Kyle Fuxa, Honglu Lin, Shreya Shrestha, Hanwen Fan, Nick Diaz, Joel Berinstein, Rishi Naik, Yuxiao Zhou, Xiaoguang Dong   +10 more
wiley   +1 more source

Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models

Nature Communications
Intestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism prevented inflammation and fibrosis in extra-intestinal organs, we aimed to evaluate mineralocorticoid ...
Asma Amamou, Mathilde Leboutte, Jonathan Breton, David Ribet, Pierre-Alain Thiebaut, Christine Bôle-Feysot, Charlène Guérin, Kanhia Aublé, Elise Rebollo, Lise Ratel, Benjamin Bonnard, Alexis Goichon, Louison Leblond, Moutaz Aziz, Elodie Fermant, Frédéric Jaisser, Guillaume Savoye, Rachel Marion-Letellier   +17 more
doaj   +1 more source

Food‐Based Edible Wireless Sensing Device with Isotropic Electromagnetic Response for Gastrointestinal Monitoring

Advanced Materials Technologies, EarlyView.
A sensor is fabricated that reflects electromagnetic waves wirelessly using only edible materials. The substrate is made of edible materials such as sugar and starch, and the electrodes are made of gold. This sensor has isotropic electromagnetic wave characteristics in response to rotation.
Ryosuke Matsuda, Kentaro Tomita, Shion Miura, Michiyuki Satoh, Tetsuo Kan, Hiroaki Onoe   +5 more
wiley   +1 more source