Results 41 to 50 of about 813,636 (315)

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm
Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and ...
Yao Shen, Nairui Fan, Shu‐xia Ma, Xin Cheng, Xuesong Yang, Guang Wang   +5 more
semanticscholar   +1 more source

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease.

Cell Host and Microbe, 2018
Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract ...
Kassem Makki, E. Deehan, J. Walter, F. Bäckhed   +3 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Gut Microbiota and Obesity

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2023
Obesity is a global health concern associated with a wide range of diseases, including diabetes, metabolic syndrome, fatty liver, and cardiovascular conditions. Recent studies highlight the significant role of gut microbiota in obesity. Research indicates notable changes in the composition and diversity of gut microbiota in individuals diagnosed with ...
openaire   +3 more sources

The gut microbiota-immune-brain axis: Therapeutic implications

Cell Reports Medicine
Summary The microbiota-gut-brain axis has major implications for human health including gastrointestinal physiology, brain function, and behavior. The immune system represents a key pathway of communication along this axis with the microbiome implicated ...
K. O'Riordan, G. Moloney, Lily Keane, Gerard Clarke, J. Cryan   +4 more
semanticscholar   +1 more source

Role of gut microbiota in type 2 diabetes pathophysiology

EBioMedicine, 2020
A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review,
M. Gurung, Zhi-Peng Li, H. You, R. Rodrigues, D. Jump, A. Morgun, N. Shulzhenko   +6 more
semanticscholar   +1 more source

The gut–liver axis and gut microbiota in health and liver disease

Nature Reviews Microbiology, 2023
The trillions of microorganisms in the human intestine are important regulators of health, and disruptions in the gut microbial communities can cause disease.
C. Hsu, B. Schnabl
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut–microbiota composition during activity-based anorexia in mice

Biology of Sex Differences
Rationale Patients with anorexia nervosa (AN) often present sleep disorders and circadian hormonal dysregulation. The role of the microbiota–gut–brain axis in the regulation of feeding behavior has emerged during the last decades but its relationships ...
Colin Salaün, Marine Courvalet, Léna Rousseau, Kévin Cailleux, Jonathan Breton, Christine Bôle-Feysot, Charlène Guérin, Marion Huré, Alexis Goichon, Jean-Claude do Rego, Pierre Déchelotte, David Ribet, Najate Achamrah, Moïse Coëffier   +13 more
doaj   +1 more source

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, development ...
Jian Sheng Loh, Wen-Qi Mak, Lily Tan, Chu-Xin Ng, Hong-Hao Chan, Shiau Hueh Yeow, J. Foo, Sze-Ong Yong, C. W. How, K. Khaw   +9 more
semanticscholar   +1 more source