Results 51 to 60 of about 813,636 (315)

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

Journal of Lipid Research, 2013
Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy metabolism.
Gijs den Besten, K. van Eunen, A. Groen, K. Venema, D. Reijngoud, Barbara M. Bakker   +5 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Introduction to the human gut microbiota

Biochemical Journal, 2017
The human gastrointestinal (GI) tract harbours a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host during homeostasis and disease.
E. Thursby, N. Juge
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Chronic activity-based anorexia triggers a glial response in the hippocampus independent of intestinal epithelial toll-like receptor 4

Journal of Neuroinflammation
Anorexia nervosa is characterized by maladaptive eating behavior and psychiatric comorbidities, which could be explained by a neuroinflammation. A gut dysbiosis could link gastrointestinal alterations to central dysfunctions, particularly via the toll ...
Léna Rousseau, Tanguy Demangeat, Colin Salaün, Clara Queguiner, Charlène Guérin, Christine Bôle-Feysot, Oudiayé Maiga, Adam Tiffay, Fatima Léon, Léa Cornaille, David Ribet, Jean-Claude do Rego, Jean-Luc do Rego, Ludovic Langlois, Moïse Coëffier   +14 more
doaj   +1 more source

The direct and gut microbiota-mediated effects of dietary bile acids on the improvement of gut barriers in largemouth bass (Micropterus salmoides)

Animal Nutrition, 2023
Fish gut barrier damage under intensive culture model is a significant concern for aquaculture industry. This study aimed to investigate the effects of bile acids (BAs) on gut barriers in Micropterus salmoides.
Rui Xia, Qingshuang Zhang, Dongmei Xia, Qiang Hao, Qianwen Ding, Chao Ran, Yalin Yang, Aizhi Cao, Zhen Zhang, Zhigang Zhou   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gut microbiota and tuberculosis

iMeta
AbstractTuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a significant global health challenge. Recent advancements in gut microbiota (GM) research have shed light on the intricate relationship between GM and TB, suggesting that GM alterations may influence host susceptibility, disease progression, and response to antituberculosis
Yanhua Liu, Ling Yang, Maryam Meskini, Anjana Goel, Monique Opperman, Sagar Singh Shyamal, Ajay Manaithiya, Meng Xiao, Ruizi Ni, Yajing An, Mingming Zhang, Yuan Tian, Shuang Zhou, Zhaoyang Ye, Li Zhuang, Linsheng Li, Istuti Saraswat, Ankita Kar, Syed Luqman Ali, Shakir Ullah, Syed Yasir Ali, Shradha Kaushik, Tianmu Tian, Mingyang Jiao, Shujun Wang, Giulia Ghisleni, Alice Armanni, Sara Fumagalli, WenYu Wang, Chao Cao, Maria Carpena, Miguel A. Prieto, Antonia Bruno, Chanyuan Jin, Hanqing Hu, Yuhang Zhang, Ilse du Preez, Ashok Aspatwar, Lingxia Zhang, Wenping Gong   +39 more
openaire   +3 more sources

Sex-dependent effects of a high fat diet on metabolic disorders, intestinal barrier function and gut microbiota in mouse

Scientific Reports
Obesity is often associated with sex-dependent metabolic complications, in which altered intestinal barrier function and gut microbiota contribute. We aimed to characterize in mice the sex-dependent effects of a high fat diet on these parameters.
Candice Lefebvre, Adam Tiffay, Charles-Edward Breemeersch, Virginie Dreux, Christine Bôle-Feysot, Charlène Guérin, Jonathan Breton, Elise Maximin, Magali Monnoye, Pierre Déchelotte, Véronique Douard, Alexis Goichon, Moïse Coëffier   +12 more
doaj   +1 more source

Intestinal epithelial TLR4 knock out induces sex-specific effects on gut barrier and microbiome in an activity-based anorexia model

Gut Microbes
The role of the microbiota‒gut‒brain axis in the pathophysiology of anorexia nervosa has emerged in recent decades. Increased expression of Toll-like receptor 4 (TLR4) has been reported in the intestinal epithelial cells (IEC) of activity-based anorexia (
Colin Salaün, Marion Huré, Charlène Guérin, Christine Bôle-Feysot, Audrey Valentin, Fatima Léon, Sarah Lenoir, Jean-Luc do-Rego, Jean-Claude do-Rego, Ludovic Langlois, David Ribet, Najate Achamrah, Moïse Coëffier   +12 more
doaj   +1 more source