Results 71 to 80 of about 715,974 (268)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Enteric nervous system in exercise physiology: a microbiota-neural interface

npj Metabolic Health and Disease
Exercise responses vary widely among individuals, yet the biological basis of this variability remains poorly understood. Microbiota-derived metabolites operate on timescales of hours to days, making them insufficient to explain rapid gastrointestinal ...
Hui-Ling Chen, Jia-Ting Huang, Jian-Jun Guo, Li-Shun Wang   +3 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Comprehensive analysis of stearoyl-coenzyme A desaturase in prostate adenocarcinoma: insights into gene expression, immune microenvironment and tumor progression

Frontiers in Immunology
Prostate adenocarcinoma (PRAD) is a prevalent global malignancy which depends more on lipid metabolism for tumor progression compared to other cancer types.
Jie Wang, Liang Ying, He Xiong, Duan-Rui Zhou, Yi-Xuan Wang, Hui-Lian Che, Zhang-Feng Zhong, Guo-Sheng Wu, Yun-Jun Ge   +8 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Gut Microbiota and NAFLD: Pathogenetic Mechanisms, Microbiota Signatures, and Therapeutic Interventions

, 2021
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Its worldwide prevalence is rapidly increasing and is currently estimated at 24%.
Miloslav Kverka, Tomas Hrncir, Pavlina Kralickova, Lucia Hrncirova, Vladimira Machova, Helena Tlaskalova-Hogenova, Jan Krejsek, Klara Kostovcikova, Robert Hromadka, Eva Trckova   +9 more
core   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Phenyllactic Acid Restores Intestinal Epithelial Barrier to Alleviate Hypertriglyceridemic Acute Pancreatitis via a PPARγ-Dependent Mechanism

Antioxidants
Hypertriglyceridemic acute pancreatitis (HTG-AP) progresses rapidly with poor prognosis. Intestinal barrier dysfunction and excessive oxidative stress contribute to its pathogenesis, but specific mediators linking gut injury, oxidative stress and ...
Ze-Yun Cao, Xun Zou, Hong-Li Li, Xuan Kong, Li-Long Pan, Jun Yang, Xiao-Liang Dong   +6 more
doaj   +1 more source

Toxicity and Impact of Silica Nanoparticles on the Configuration of Gut Microbiota in Immunodeficient Mice

, 2023
Nanoparticles (NPs), having exceptional physicochemical and electrical characteristics with lower toxicity, have evolved as dynamic drug delivery carriers in living organisms.
Sana Shabbir, Kunlun Huang, Xiaoyun He, Yanzhou Hu, Wentao Xu   +4 more
core   +1 more source

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source