Results 71 to 80 of about 813,636 (315)

Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy

Chinese Medicine
Background Lipid metabolism is crucial in cancer progression. Lipid droplets (LDs) generated in cancer cells can act as protective mechanisms through alleviating lipotoxicity under stress conditions.
Guosheng Wu, Liang Ying, Qian Zhang, He Xiong, Jie Wang, Sitao Chen, Chen Yang, Yiyuan Jin, Zengwei Lai, Ninghan Feng, Yunjun Ge   +10 more
doaj   +1 more source

Immunoregulatory role of the gut microbiota in inflammatory depression

Nature Communications
Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an observational trial, we first analyze the gut microbiota composition in
Penghong Liu, Zhifen Liu, Ji-Zhi Wang, Jun-Yang Wang, Mingxu Gao, Yanyan Zhang, Chun-Xia Yang, Ai-Xia Zhang, Gai-Zhi Li, Xin-Rong Li, Sha Liu, Lixin Liu, Ning Sun, Kerang Zhang   +13 more
semanticscholar   +1 more source

Diversity, stability and resilience of the human gut microbiota

Nature, 2012
Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host interactions.
C. Lozupone, Jesse Stombaugh, J. Gordon, J. Jansson, R. Knight   +4 more
semanticscholar   +1 more source

Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study

BMC Medicine, 2023
Background Evidence from observational studies and clinical trials suggests that the gut microbiota is associated with cancer. However, the causal association between gut microbiota and cancer remains to be determined.
Yiwen Long, Lanhua Tang, Yang-Ying Zhou, Shu-Shan Zhao, Hong Zhu   +4 more
semanticscholar   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice

Nature Communications
Despite decades of studies into the mechanisms underlying acute kidney injury (AKI), the effective clinical therapies are still limited. Here we report that the development of AKI was attenuated by conditional knockout of phosphoglycerate kinase 1 (PGK1)
Xue-Xue Zhu, Xin-Yu Meng, Ao-Yuan Zhang, Chen-Yang Zhao, Yi-Ting Wei, Yuan-Yuan Wen, Jia-Bao Su, Xiao Fu, Guo Chen, An-Jing Xu, Meng-Yuan Wang, Le-Ming Ji, Neng Bao, Zheng-Yang Bao, Na Li, Qing-Bo Lu, Hai-Jian Sun   +16 more
doaj   +1 more source

Critical role of the gut microbiota in immune responses and cancer immunotherapy

Journal of Hematology & Oncology
The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence of the connections between the gut microbiota and cancer immunotherapy. Therefore, understanding the
Zehua Li, Weixi Xiong, Zhu Liang, Jinyu Wang, Ziyi Zeng, D. Kołat, Xi Li, Dong Zhou, Xuewen Xu, Linyong Zhao   +9 more
semanticscholar   +1 more source

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Signal Transduction and Targeted Therapy, 2023
In the past period, due to the rapid development of next-generation sequencing technology, accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic response. More importantly, available
Lin-Yong Zhao, Jia-Xin Mei, Gang Yu, L. Lei, Weihan Zhang, Kai Liu, Xiao-Long Chen, D. Kołat, Kun Yang, Jian-Kun Hu   +9 more
semanticscholar   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation

Frontiers in Pharmacology
Pulmonary hypertension (PH) is a complex and progressive vascular disease characterized by elevated pulmonary arterial pressure (PAP) and vascular resistance, leading to right ventricular failure and, ultimately, death.
Xue-Xue Zhu, Chen-Yang Zhao, Qing-Bo Lu, Ao-Yuan Zhang, Xin-Yu Meng, Jia-Bao Su, Guo Chen, An-Jing Xu, Hai-Jian Sun, Xiao-Wei Nie   +9 more
doaj   +1 more source