Results 61 to 70 of about 306,961 (316)

Diabetes and gut microbiota

World Journal of Diabetes, 2021
The prevalence of diabetes has increased rapidly throughout the world in recent years. Currently, approximately 463 million people are living with diabetes, and the number has tripled over the last two decades. Here, we describe the global epidemiology of diabetes in 2019 and forecast the trends to 2030 and 2045 in China, India, USA, and the globally ...
Xi, Yue, Xu, Peng-Fei
openaire   +2 more sources

Cardiac function of colorectal cancer mice is remotely controlled by gut microbiota: regulating serum metabolites and myocardial cytokines

Animal Microbiome
Several studies have indicated that the dysregulation of microbial metabolites and the inflammatory environment resulting from microbial dysbiosis may contribute to the occurrence and progression of cardiovascular diseases.
Zhan-Kui Gao, Chao-Yuan Fan, Bo-Wen Zhang, Jia-Xin Geng, Xing Han, Dan-Qi Xu, Muhammad Arshad, Hao-Xuan Sun, Jiong-Yi Li, Xiangyuan Jin, Xiao-Qin Mu   +10 more
doaj   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy

Chinese Medicine
Background Lipid metabolism is crucial in cancer progression. Lipid droplets (LDs) generated in cancer cells can act as protective mechanisms through alleviating lipotoxicity under stress conditions.
Guosheng Wu, Liang Ying, Qian Zhang, He Xiong, Jie Wang, Sitao Chen, Chen Yang, Yiyuan Jin, Zengwei Lai, Ninghan Feng, Yunjun Ge   +10 more
doaj   +1 more source

Partial replacement of pelleted feed by moist fermented feed improved the feed conversion efficiency, liver and intestine health, and gut microbiota structure in common carp (Cyprinus carpio)

Aquaculture Reports, 2023
This study aimed to explore whether the substitution of basic pellet feed by different proportions of moist fermented pellet feed affect the growth performance, liver and gut health, and intestinal microbiota structure of common carp (Cyprinus carpio ...
Qingshuang Zhang, Xiufang Jing, Yajie Zhao, Dongmei Xia, Shubin Liu, Daojun Li, Qiang Hao, Mengxin Wang, Zhe Yu, Shenghui Li, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou   +13 more
doaj   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice

Nature Communications
Despite decades of studies into the mechanisms underlying acute kidney injury (AKI), the effective clinical therapies are still limited. Here we report that the development of AKI was attenuated by conditional knockout of phosphoglycerate kinase 1 (PGK1)
Xue-Xue Zhu, Xin-Yu Meng, Ao-Yuan Zhang, Chen-Yang Zhao, Yi-Ting Wei, Yuan-Yuan Wen, Jia-Bao Su, Xiao Fu, Guo Chen, An-Jing Xu, Meng-Yuan Wang, Le-Ming Ji, Neng Bao, Zheng-Yang Bao, Na Li, Qing-Bo Lu, Hai-Jian Sun   +16 more
doaj   +1 more source

Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation

Frontiers in Pharmacology
Pulmonary hypertension (PH) is a complex and progressive vascular disease characterized by elevated pulmonary arterial pressure (PAP) and vascular resistance, leading to right ventricular failure and, ultimately, death.
Xue-Xue Zhu, Chen-Yang Zhao, Qing-Bo Lu, Ao-Yuan Zhang, Xin-Yu Meng, Jia-Bao Su, Guo Chen, An-Jing Xu, Hai-Jian Sun, Xiao-Wei Nie   +9 more
doaj   +1 more source

Longitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease

Nature Communications, 2021
Fecal microbiota transplant (FMT) is emerging as a potential treatment for graft-versus-host disease (GvHD). Here, the authors examine temporal dynamics of the bacteriome, mycobiome, and virome of a patient with GvHD who received multiple FMTs.
Fen Zhang, Tao Zuo, Yun Kit Yeoh, Frankie W. T. Cheng, Qin Liu, Whitney Tang, Kitty C. Y. Cheung, Keli Yang, Chun Pan Cheung, Chow Chung Mo, Mamie Hui, Francis K. L. Chan, Chi-Kong Li, Paul K. S. Chan, Siew C. Ng   +14 more
doaj   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source