Results 51 to 60 of about 423,092 (188)

Gut microbiota as a trigger of accelerated directional adaptive evolution. Acquisition of herbivory in the context of extracellular vesicles, microRNAs and inter-kingdom crosstalk [PDF]

, 2017
According to a traditional view, the specific diet in vertebrates is one of the key factors structuring the composition of the gut microbiota. In this interpretation, the microbiota assumes a subordinate position, where the larger host shapes, through ...
Romano, Marco
core   +1 more source

Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models

Nature Communications
Intestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism prevented inflammation and fibrosis in extra-intestinal organs, we aimed to evaluate mineralocorticoid ...
Asma Amamou, Mathilde Leboutte, Jonathan Breton, David Ribet, Pierre-Alain Thiebaut, Christine Bôle-Feysot, Charlène Guérin, Kanhia Aublé, Elise Rebollo, Lise Ratel, Benjamin Bonnard, Alexis Goichon, Louison Leblond, Moutaz Aziz, Elodie Fermant, Frédéric Jaisser, Guillaume Savoye, Rachel Marion-Letellier   +17 more
doaj   +1 more source

Comprehensive analysis of stearoyl-coenzyme A desaturase in prostate adenocarcinoma: insights into gene expression, immune microenvironment and tumor progression

Frontiers in Immunology
Prostate adenocarcinoma (PRAD) is a prevalent global malignancy which depends more on lipid metabolism for tumor progression compared to other cancer types.
Jie Wang, Liang Ying, He Xiong, Duan-Rui Zhou, Yi-Xuan Wang, Hui-Lian Che, Zhang-Feng Zhong, Guo-Sheng Wu, Yun-Jun Ge   +8 more
doaj   +1 more source

Fecal microbiota transplantation inhibits colorectal cancer progression: Reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses

Frontiers in Microbiology, 2023
Many lines of evidence demonstrate the associations of colorectal cancer (CRC) with intestinal microbial dysbiosis. Recent reports have suggested that maintaining the homeostasis of microbiota and host might be beneficial to CRC patients, but the ...
Hao Yu, Hao Yu, Hao Yu, Xing-Xiu Li, Xing Han, Xing Han, Xing Han, Bin-Xin Chen, Xing-Hua Zhang, Xing-Hua Zhang, Xing-Hua Zhang, Shan Gao, Dan-Qi Xu, Dan-Qi Xu, Dan-Qi Xu, Yao Wang, Yao Wang, Yao Wang, Zhan-Kui Gao, Zhan-Kui Gao, Zhan-Kui Gao, Lei Yu, Song-Ling Zhu, Song-Ling Zhu, Li-Chen Yao, Gui-Rong Liu, Gui-Rong Liu, Gui-Rong Liu, Shu-Lin Liu, Shu-Lin Liu, Shu-Lin Liu, Shu-Lin Liu, Xiao-Qin Mu, Xiao-Qin Mu, Xiao-Qin Mu   +34 more
doaj   +1 more source

The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]

, 2016
Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core   +1 more source

The relationship between gut microbiota and spontaneous bacterial peritonitis in patients with liver cirrhosis - a literature review [PDF]

, 2019
Gut microbiota is an essential component in the pathogenesis of liver cirrhosis and its complications. There is a direct relationship between the gut and the liver called the gutliver axis through which bacteria can reach the liver through the portal ...
Fierbinteanu Braticevici, Carmen, Mazilu, Laura, Motofei, Catalina, Pantea Stoian, Anca Mihaela, Parepa, Irinel R., Paunica, Mihai, Popoiag, Roxana-Emanuela, Serban, Laura M., Suceveanu, Adrian P., Suceveanu, Andra I.   +9 more
core   +3 more sources

Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community [PDF]

, 2018
Recent studies have conflicting data regarding the presence of intra-amniotic microbiota. Viral communities are increasingly recognized as important although overlooked components of the human microbiota.
Holtz, Lori R, Lim, Efrem S, Rodriquez, Cynthia   +2 more
core   +2 more sources

Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat [PDF]

, 2016
Gut microbiota colonization is a key event for host physiology that occurs early in life. Disruption of this process leads to altered brain development which ultimately manifests as changes in brain function and behaviour in adulthood. Studies using germ-
Clarke, Gerard, Cryan, John F., Dinan, Timothy G., Golubeva, Anna V., Hoban, Alan E., McVey Neufeld, Karen A., Moloney, Rachel D., O'Sullivan, Orla, Patterson, Elaine, Stanton, Catherine   +9 more
core   +1 more source

Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice

Nature Communications
Obesity and related diseases pose a major health risk, yet current anti-obesity drugs inadequately addressing clinical needs. Here we show AA005, an annonaceous acetogenin mimic, resists obesity induced by high-fat diets and leptin mutations at non-toxic
Bing Han, Zhan-Ming Li, Xu-Yun Zhao, Kai Liang, Yu-Qin Mao, Shi-Long Zhang, Li-Ying Huang, Chao-Yue Kong, Xin Peng, Hui-Ling Chen, Jia-Ting Huang, Zhao-Xia Wu, Jin-Qing Yao, Pei-Ran Cai, Zheng-Yan Zhang, Xu-Min Zhang, Zhu-Jun Yao, Guo-Qiang Chen, Li-Shun Wang   +18 more
doaj   +1 more source

Staphylococcus warneri dampens SUMOylation and promotes intestinal inflammation

Gut Microbes
Gut bacteria play key roles in intestinal physiology, via the secretion of diversified bacterial effectors. Many of these effectors remodel the host proteome, either by altering transcription or by regulating protein post-translational modifications ...
Léa Loison, Marion Huré, Benjamin Lefranc, Jérôme Leprince, Christine Bôle-Feysot, Moïse Coëffier, David Ribet   +6 more
doaj   +1 more source