Results 61 to 70 of about 223,316 (222)

Staphylococcus warneri dampens SUMOylation and promotes intestinal inflammation

Gut Microbes
Gut bacteria play key roles in intestinal physiology, via the secretion of diversified bacterial effectors. Many of these effectors remodel the host proteome, either by altering transcription or by regulating protein post-translational modifications ...
Léa Loison, Marion Huré, Benjamin Lefranc, Jérôme Leprince, Christine Bôle-Feysot, Moïse Coëffier, David Ribet   +6 more
doaj   +1 more source

Microbiome-derived bile acids contribute to elevated antigenic response and bone erosion in rheumatoid arthritis [PDF]

arXiv, 2023
Rheumatoid arthritis (RA) is a chronic, disabling and incurable autoimmune disease. It has been widely recognized that gut microbial dysbiosis is an important contributor to the pathogenesis of RA, although distinct alterations in microbiota have been associated with this disease.
arxiv  

Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota [PDF]

arXiv, 2015
Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known.
arxiv  

Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling

Cell Communication and Signaling
Vascular calcification (VC) arises from the accumulation of calcium salts in the intimal or tunica media layer of the aorta, contributing to higher risk of cardiovascular events and mortality.
Xue-Xue Zhu, Xin-Yu Meng, Guo Chen, Jia-Bao Su, Xiao Fu, An-Jing Xu, Yao Liu, Xiao-Hui Hou, Hong-Bo Qiu, Qing-Yi Sun, Jin-Yi Hu, Zhuo-Lin Lv, Hai-Jian Sun, Hai-Bin Jiang, Zhi-Jun Han, Jian Zhu, Qing-Bo Lu   +16 more
doaj   +1 more source

New use of an old drug: mechanism of oseltamivir phosphate inhibiting liver cancer through regulation of lipophagy via NEU1

Frontiers in Pharmacology
BackgroundNeuraminidase-1 (NEU1) is an enzyme that breaks down sialic acids on glycoproteins and glycolipids. Aberrant expression of NEU1 has been linked to the progression of numerous malignancies, including liver cancer. Oseltamivir phosphate (OP) is a
Yuyu Chen, Yuyu Chen, Peiyu Han, Haixia Zhu, Wenchao Zhang, Xiaoyu Ma, Yiting He, Hetian Chen, Weiwei He, Yu Wu, Yuqiu Ge   +10 more
doaj   +1 more source

The direct and gut microbiota-mediated effects of dietary bile acids on the improvement of gut barriers in largemouth bass (Micropterus salmoides)

Animal Nutrition, 2023
Fish gut barrier damage under intensive culture model is a significant concern for aquaculture industry. This study aimed to investigate the effects of bile acids (BAs) on gut barriers in Micropterus salmoides.
Rui Xia, Qingshuang Zhang, Dongmei Xia, Qiang Hao, Qianwen Ding, Chao Ran, Yalin Yang, Aizhi Cao, Zhen Zhang, Zhigang Zhou   +9 more
doaj  

Building a Corpus for Biomedical Relation Extraction of Species Mentions [PDF]

arXiv, 2023
We present a manually annotated corpus, Species-Species Interaction, for extracting meaningful binary relations between species, in biomedical texts, at sentence level, with a focus on the gut microbiota. The corpus leverages PubTator to annotate species in full-text articles after evaluating different Named Entity Recognition species taggers.
arxiv  

The Microbiota-Gut-Brain Axis [PDF]

Physiological Reviews, 2019
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain ...
Cryan, John F., O'Riordan, Kenneth J., Cowan, Caitlin S. M., Sandhu, Kiran V., Bastiaanssen, Thomaz F. S., Boehme, Marcus, Codagnone, Martin G., Cussotto, Sofia, Fulling, Christine, Golubeva, Anna V., Guzzetta, Katherine E., Jaggar, Minal, Long-Smith, Caitriona M., Lyte, Joshua M., Martin, Jason A., Molinero-Perez, Alicia, Moloney, Gerard, Morelli, Emanuela, Morillas, Enrique, O'Connor, Rory, Cruz-Pereira, Joana S., Peterson, Veronica L., Rea, Kieran, Ritz, Nathaniel L., Sherwin, Eoin, Spichak, Simon, Teichman, Emily M., van de Wouw, Marcel, Ventura-Silva, Ana Paula, Wallace-Fitzsimons, Shauna E., Hyland, Niall, Clarke, Gerard, Dinan, Timothy G.   +32 more
openaire   +4 more sources

Dysbiosis of the gut microbiota in disease [PDF]

Microbial Ecology in Health & Disease, 2015
There is growing evidence that dysbiosis of the gut microbiota is associated with the pathogenesis of both intestinal and extra-intestinal disorders. Intestinal disorders include inflammatory bowel disease, irritable bowel syndrome (IBS), and coeliac disease, while extra-intestinal disorders include allergy, asthma, metabolic syndrome, cardiovascular ...
Carding, S, Verbeke, K, Vipond, DT, Corfe, BM, Owen, LJ   +4 more
openaire   +6 more sources

Synthesis of lipoic acid ferulate and evaluation of its ability to preserve fish oil from oxidation during accelerated storage

Food Chemistry: X, 2023
Lipoic acid ferulate (LAF) was synthesized and its anti-free radical ability in vitro was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonicacid) (ABTS) assays. Protective effects of LAF in stabilizing
Zhiyong Xue, Juan Liu, Qing Li, Yuanyuan Yao, Yalin Yang, Chao Ran, Zhen Zhang, Zhigang Zhou   +7 more
doaj