Results 61 to 70 of about 932,371 (335)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut–microbiota composition during activity-based anorexia in mice

Biology of Sex Differences
Rationale Patients with anorexia nervosa (AN) often present sleep disorders and circadian hormonal dysregulation. The role of the microbiota–gut–brain axis in the regulation of feeding behavior has emerged during the last decades but its relationships ...
Colin Salaün, Marine Courvalet, Léna Rousseau, Kévin Cailleux, Jonathan Breton, Christine Bôle-Feysot, Charlène Guérin, Marion Huré, Alexis Goichon, Jean-Claude do Rego, Pierre Déchelotte, David Ribet, Najate Achamrah, Moïse Coëffier   +13 more
doaj   +1 more source

Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

Gut, 2021
Objective Programmed death 1 and its ligand 1 (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, the response rate needs to be improved.
Jumin Huang, Di Liu, Yuwei Wang, Liang Liu, Jian Li, Jing Yuan, Zhihong Jiang, Ze-bo Jiang, W. Hsiao, Haizhou Liu, Imran Khan, Ying Xie, Jianlin Wu, Ya-Jia Xie, Yizhong Zhang, Yu Fu, Junyi Liao, Wenjun Wang, Huanling Lai, A-Xi Shi, Jun Cai, Lianxiang Luo, Run-Ze Li, Xiaojun Yao, Xing-Xing Fan, Qibiao Wu, Zhongqiu Liu, Pei-yu Yan, Jingguang Lu, Ming-rong Yang, Lin Wang, Yabing Cao, Hong Wei, E. Leung   +33 more
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Sex-dependent effects of a high fat diet on metabolic disorders, intestinal barrier function and gut microbiota in mouse

Scientific Reports
Obesity is often associated with sex-dependent metabolic complications, in which altered intestinal barrier function and gut microbiota contribute. We aimed to characterize in mice the sex-dependent effects of a high fat diet on these parameters.
Candice Lefebvre, Adam Tiffay, Charles-Edward Breemeersch, Virginie Dreux, Christine Bôle-Feysot, Charlène Guérin, Jonathan Breton, Elise Maximin, Magali Monnoye, Pierre Déchelotte, Véronique Douard, Alexis Goichon, Moïse Coëffier   +12 more
doaj   +1 more source

Longitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease

Nature Communications, 2021
Fecal microbiota transplant (FMT) is emerging as a potential treatment for graft-versus-host disease (GvHD). Here, the authors examine temporal dynamics of the bacteriome, mycobiome, and virome of a patient with GvHD who received multiple FMTs.
Fen Zhang, Tao Zuo, Yun Kit Yeoh, Frankie W. T. Cheng, Qin Liu, Whitney Tang, Kitty C. Y. Cheung, Keli Yang, Chun Pan Cheung, Chow Chung Mo, Mamie Hui, Francis K. L. Chan, Chi-Kong Li, Paul K. S. Chan, Siew C. Ng   +14 more
doaj   +1 more source

The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host

Frontiers in Oncology, 2022
Abnormal metabolic alterations of cancer cells and the host play critical roles in the occurrence and development of tumors. Targeting cancer cells and host metabolism can provide novel diagnosis indicators and intervention targets for tumors.
Jia-Ting Huang, Jia-Ting Huang, Yu-Qin Mao, Yu-Qin Mao   +3 more
doaj   +1 more source

Microbiome-gut-brain axis and toll-like receptors in parkinson\u2019s disease [PDF]

, 2018
Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy, which involves all districts of the brain-gut axis, including the central, autonomic and enteric nervous systems.
Caputi, Valentina, Giron, Maria Cecilia
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Cardiac function of colorectal cancer mice is remotely controlled by gut microbiota: regulating serum metabolites and myocardial cytokines

Animal Microbiome
Several studies have indicated that the dysregulation of microbial metabolites and the inflammatory environment resulting from microbial dysbiosis may contribute to the occurrence and progression of cardiovascular diseases.
Zhan-Kui Gao, Chao-Yuan Fan, Bo-Wen Zhang, Jia-Xin Geng, Xing Han, Dan-Qi Xu, Muhammad Arshad, Hao-Xuan Sun, Jiong-Yi Li, Xiangyuan Jin, Xiao-Qin Mu   +10 more
doaj   +1 more source