Results 71 to 80 of about 932,371 (335)

Research advances in the structure, function, and regulation of the gill barrier in teleost fish

Water Biology and Security, 2023
The gill is an important organ in fish that is involved in various physiological functions, including respiration, filter-feeding, ammonia nitrogen excretion, and osmoregulation. The physiological functions of gills are closely related to their structure,
Xingyu Chen, Shubin Liu, Qianwen Ding, Tsegay Teame, Yalin Yang, Chao Ran, Zhen Zhang, Zhigang Zhou   +7 more
doaj   +1 more source

Introduction to the human gut microbiota

Biochemical Journal, 2017
The human gastrointestinal (GI) tract harbours a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host during homeostasis and disease.
E. Thursby, N. Juge
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis

International Journal of Molecular Sciences, 2022
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host, and related metabolites have profound effects on human health ...
P. Portincasa, L. Bonfrate, M. Vacca, M. De Angelis, Ilaria Farella, Elisa Lanza, M. Khalil, D. Q. Wang, M. Sperandio, A. Di Ciaula   +9 more
semanticscholar   +1 more source

Breast Cancer and Aging: Understanding the Complex Relationship and Implications for Prevention and Screening

Aging and Cancer, EarlyView.
ABSTRACT Background Breast cancer is a multifactorial disease that affects many women worldwide. Age is the most important risk factor for breast cancer, with an increased incidence markedly after the age of 50. The relationships of aging to breast cancer have been thoroughly examined, and notable connections regarding various age‐related changes in ...
Mehran Radak, Armin Sharifi, Derek Richard, Hossein Fallahi   +3 more
wiley   +1 more source

Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy

Chinese Medicine
Background Lipid metabolism is crucial in cancer progression. Lipid droplets (LDs) generated in cancer cells can act as protective mechanisms through alleviating lipotoxicity under stress conditions.
Guosheng Wu, Liang Ying, Qian Zhang, He Xiong, Jie Wang, Sitao Chen, Chen Yang, Yiyuan Jin, Zengwei Lai, Ninghan Feng, Yunjun Ge   +10 more
doaj   +1 more source

Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation

Frontiers in Pharmacology
Pulmonary hypertension (PH) is a complex and progressive vascular disease characterized by elevated pulmonary arterial pressure (PAP) and vascular resistance, leading to right ventricular failure and, ultimately, death.
Xue-Xue Zhu, Chen-Yang Zhao, Qing-Bo Lu, Ao-Yuan Zhang, Xin-Yu Meng, Jia-Bao Su, Guo Chen, An-Jing Xu, Hai-Jian Sun, Xiao-Wei Nie   +9 more
doaj   +1 more source

Identification of mucin degraders of the human gut microbiota [PDF]

, 2021
Stefano Raimondi, Eliana Musmeci, Francesco Candeliere, Alberto Amaretti, Maddalena Rossi   +4 more
openalex   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice

Nature Communications
Despite decades of studies into the mechanisms underlying acute kidney injury (AKI), the effective clinical therapies are still limited. Here we report that the development of AKI was attenuated by conditional knockout of phosphoglycerate kinase 1 (PGK1)
Xue-Xue Zhu, Xin-Yu Meng, Ao-Yuan Zhang, Chen-Yang Zhao, Yi-Ting Wei, Yuan-Yuan Wen, Jia-Bao Su, Xiao Fu, Guo Chen, An-Jing Xu, Meng-Yuan Wang, Le-Ming Ji, Neng Bao, Zheng-Yang Bao, Na Li, Qing-Bo Lu, Hai-Jian Sun   +16 more
doaj   +1 more source