Results 71 to 80 of about 693,536 (346)

Sex-dependent effects of a high fat diet on metabolic disorders, intestinal barrier function and gut microbiota in mouse

Scientific Reports
Obesity is often associated with sex-dependent metabolic complications, in which altered intestinal barrier function and gut microbiota contribute. We aimed to characterize in mice the sex-dependent effects of a high fat diet on these parameters.
Candice Lefebvre, Adam Tiffay, Charles-Edward Breemeersch, Virginie Dreux, Christine Bôle-Feysot, Charlène Guérin, Jonathan Breton, Elise Maximin, Magali Monnoye, Pierre Déchelotte, Véronique Douard, Alexis Goichon, Moïse Coëffier   +12 more
doaj   +1 more source

Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axis

Pharmacological Research, 2023
Nonalcoholic steatohepatitis (NASH) is the major cause of liver dysfunction. Animal and population studies have shown that mitochondrial aldehyde dehydrogenase (ALDH2) is implicated in fatty liver disease.
Zhan-Ming Li, Chao-Yue Kong, Yu-Qin Mao, Hui-Ling Chen, Shi-Long Zhang, Jia-Ting Huang, Jin-Qing Yao, Pei-Ran Cai, Nuo Xie, Bing Han, Li-Shun Wang   +10 more
doaj  

Disordered Gut Microbiota Correlates With Altered Fecal Bile Acid Metabolism and Post-cholecystectomy Diarrhea

Frontiers in Microbiology, 2022
Post-cholecystectomy diarrhea (PCD) is a common complication of gallbladder removal, and gut microbiota changes have been determined in PCD patients. Bile acid diarrhea (BAD) is supposed to be the main pathogenic factor for PCD due to the disrupted fecal
Yayun Xu, Yayun Xu, Hui Jing, Hui Jing, Jianfa Wang, Jianfa Wang, Shilong Zhang, Qimeng Chang, Qimeng Chang, Zhanming Li, Zhanming Li, Xubo Wu, Xubo Wu, Ziping Zhang, Ziping Zhang   +14 more
doaj   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Cardiac function of colorectal cancer mice is remotely controlled by gut microbiota: regulating serum metabolites and myocardial cytokines

Animal Microbiome
Several studies have indicated that the dysregulation of microbial metabolites and the inflammatory environment resulting from microbial dysbiosis may contribute to the occurrence and progression of cardiovascular diseases.
Zhan-Kui Gao, Chao-Yuan Fan, Bo-Wen Zhang, Jia-Xin Geng, Xing Han, Dan-Qi Xu, Muhammad Arshad, Hao-Xuan Sun, Jiong-Yi Li, Xiangyuan Jin, Xiao-Qin Mu   +10 more
doaj   +1 more source

The gut microbiota as an environmental factor that regulates fat storage.

Proceedings of the National Academy of Sciences of the United States of America, 2004
New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (microbiota) is essential for processing dietary polysaccharides.
F. Bäckhed, Hao Ding, Ting Wang, L. Hooper, G. Koh, A. Nagy, C. Semenkovich, J. Gordon   +7 more
semanticscholar   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation

Frontiers in Pharmacology
Pulmonary hypertension (PH) is a complex and progressive vascular disease characterized by elevated pulmonary arterial pressure (PAP) and vascular resistance, leading to right ventricular failure and, ultimately, death.
Xue-Xue Zhu, Chen-Yang Zhao, Qing-Bo Lu, Ao-Yuan Zhang, Xin-Yu Meng, Jia-Bao Su, Guo Chen, An-Jing Xu, Hai-Jian Sun, Xiao-Wei Nie   +9 more
doaj   +1 more source

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Gut, 2020
Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is an increasing healthcare burden worldwide. We examined the role of dietary cholesterol in driving NAFLD–HCC through modulating gut microbiota and its ...
Xiang Zhang, O. Coker, E. Chu, Kaili Fu, H. C. Lau, Yi-Xiang J. Wang, A. Chan, Hong Wei, Xiaoyong Yang, J. Sung, Jun Yu   +10 more
semanticscholar   +1 more source

Gut microbiota and autism

Journal of Education, Health and Sport, 2019
Boreński Grzegorz, Wójcik Magdalena, Poleszak Julita, Szabat Przemysław, Szabat Marta, Milanowska Joanna. Gut microbiota and autism. Journal of Education, Health and Sport. 2019;9(9):204-212. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3395320 http://ojs.ukw.edu.pl/index.php/johs/article/view/7380 The journal has had 5 points in Ministry of ...
Grzegorz Boreński, Magdalena Wójcik, Julita Poleszak, Przemysław Szabat, Marta Szabat, Joanna Milanowska   +5 more
openaire   +3 more sources