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Gut virome in early life: origins and implications

Current Opinion in Virology, 2022
The human body is colonized by a multitude of bacteria, fungi, and viruses, which play important roles in health and disease. Microbial colonization during early life is thought to be a particularly important period with lasting consequences for health.
Elizabeth A, Kennedy, Lori R, Holtz
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A changing gut virome ecological landscape with longevity

Trends in Microbiology, 2023
A recent study (Johansen et al., 2023) shows how the ecological composition of the human gut virome changes with age, showing a decline in core taxa and an enrichment of subdominant taxa, similar to what has been observed in the gut bacteriomes of centenarians.
Tomasz Wilmanski, Sean M. Gibbons
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Giant oversights in the human gut virome

Gut, 2019
We read with interest the paper by Zuo  et al ,1 which used deep sequencing to identify gut mucosal virome alterations in individuals with UC. One of many interesting findings reported by the authors was the detection of giant viruses infecting algae and amoeba ( Mimivirus and Chrysochromulina ericina virus).
Thomas D S Sutton   +2 more
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HIV, AIDS, and the virome: Gut reactions

Cell Host & Microbe, 2022
In 2016 we discovered alterations in the gut bacterial and viral populations in HIV-associated AIDS (Monaco et al., 2016). Herein, I relate the background behind these developments and discuss how they advanced the field and propelled my current research endeavors.
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Gut virome dysbiosis following focal cerebral ischemia in mice

Journal of Cerebral Blood Flow & Metabolism, 2022
Stroke leads to gut bacterial dysbiosis that impacts the post-stroke outcome. The gut microbiome also contains a high abundance of viruses which might play a crucial role in disease progression and recovery by modulating the metabolism of both host and host’s gut bacteria.
Bharath Chelluboina   +4 more
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Revelation in the gut virome

Science, 2018
Virology Some of the trillions of bacteria in the human gut are beginning to disclose their secrets. By contrast, we know little about the viruses other than that there are even more of them and most parasitize bacteria and other microbiota. Guerin et al.
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Progress and prospects of the healthy human gut virome

Current Opinion in Virology, 2021
Not all viruses associated with humans cause disease. Non-pathogenic human-infecting viruses are predicted as important for immune system induction and preparation. Phages that infect bacteria are the most abundant predators of the human microbial ecosystem, promoting and maintaining bacterial diversity. Metagenomic analyses of the human gut virome and
Stephen R Stockdale, Colin Hill
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Advances and challenges in cataloging the human gut virome

Cell Host & Microbe, 2022
The human gut virome, which is often referred to as the "dark matter" of the gut microbiome, remains understudied. A better understanding of the composition and variations of the gut virome across populations is critical for exploring its impact on diseases and health.
Junhua, Li   +3 more
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Metagenome of human gut virome and human gut microbiota

2022
Metagenome of human gut virome and human gut ...
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Authors response: giant oversights in the human gut virome

Gut, 2019
We explored gut mucosal virome alterations in UC1 and appreciate the insightful comments from the authors who highlighted some of the important limitations of human gut virome studies.2 Unlike the bacteria microbiome, the gut virome remains largely underexplored.
Tao Zuo, Siew C Ng
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