Results 61 to 70 of about 3,013 (178)

The Lectin LecA Sensitizes the Human Stretch-Activated Channel TREK-1 but Not Piezo1 and Binds Selectively to Cardiac Non-myocytes

Frontiers in Physiology, 2020
The healthy heart adapts continuously to a complex set of dynamically changing mechanical conditions. The mechanical environment is altered by, and contributes to, multiple cardiac diseases.
Elisa Darkow, Elisa Darkow, Elisa Darkow, Elisa Darkow, Eva A. Rog-Zielinska, Eva A. Rog-Zielinska, Josef Madl, Josef Madl, Annette Brandel, Annette Brandel, Lina Siukstaite, Lina Siukstaite, Ramin Omidvar, Ramin Omidvar, Peter Kohl, Peter Kohl, Peter Kohl, Ursula Ravens, Ursula Ravens, Winfried Römer, Winfried Römer, Winfried Römer, Rémi Peyronnet, Rémi Peyronnet   +23 more
doaj   +1 more source

Olikomycin A Disrupts Gram‐Positive Bacterial Membranes Through Calcium‐Dependent Binding to Phosphatidylglycerol

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Olikomycin A, a calcium‐dependent lipopeptide antibiotic, targets Gram‐positive bacteria by binding to phosphatidylglycerol and rapidly disrupting membrane integrity. Unlike daptomycin, it induces extensive membrane remodeling, vesicle deformation, and fragmentation.
Luisa Munz, Olga Makshakova, Sara Marchi, Winfried Römer, Andreas Bechthold   +4 more
wiley   +1 more source

Studying antibiotic–membrane interactions via X‐ray diffraction and fluorescence microscopy

FEBS Open Bio, 2015
Antibiotic drug resistance is a serious issue for the treatment of bacterial infection. Understanding the resistance to antibiotics is a key issue for developing new drugs.
Yi-Ting Sun, Ping-Yuan Huang, Cheng-Hao Lin, Kuan-Rong Lee, Ming-Tao Lee   +4 more
doaj   +1 more source

Light‐Activated Communication Between Synthetic and Living Cells via Photoresponsive Membranes

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
Light‐triggered membrane rupture of SCs enables controlled release of adenosine triphosphate (ATP) and histamine, which activate purinergic and histaminergic signaling in HeLa cells, leading to intracellular Ca2+ mobilization. This biomimetic communication platform provides a simple strategy for engineering remotely controlled chemical signaling ...
Roberto Barbaro, Paola Albanese, Matilde Colella, Davide Lattarulo, Samrat Saha, Jack L.‐Y. Chen, Fabio Mavelli, Federico Rossi, Emiliano Altamura   +8 more
wiley   +1 more source

Membrane‐Associated Biomolecules for Synthetic Cell Signalling

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Membrane‐associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering. This review explores how these biomolecules enable complementary strategies for cell tethering, vesicle generation and fusion, signal transmission, and signal transduction.
Chelsea Dack, Bingkun Li, Charlie Newell, Michael J. Booth   +3 more
wiley   +1 more source

Membrane Interaction of α-Synuclein in Different Aggregation States

Journal of Parkinson’s Disease, 2011
Aggregated α-synuclein in Lewy bodies is one of the hallmarks of Parkinson's disease (PD). Earlier observations of α-synuclein aggregates in neurons grafted into brains of PD patients suggested cell-to-cell transfer of α-synuclein and a prion-like ...
Marie Grey, Sara Linse, Hanna Nilsson, Patrik Brundin, Emma Sparr   +4 more
doaj   +1 more source

Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii

Molecules, 2010
In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine.
Bomi Hwang, Juneyoung Lee, Qing-He Liu, Eun-Rhan Woo, Dong Gun Lee   +4 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

PEG Alternatives in Liposomal Nanocarriers: Physicochemical Characteristics and Sustainable Process Strategies

Asia-Pacific Journal of Chemical Engineering, Volume 21, Issue 4, July/August 2026.
ABSTRACT The global trend toward sustainable and intensified bioprocesses is driving innovation in the design and scalable synthesis of liposomal nanocarriers, a cornerstone of modern drug delivery. For decades, these nanosystems have relied exclusively on polyethylene glycol (PEG) for their sustained circulation in vivo, but they are currently ...
Chandra Has
wiley   +1 more source

Artificial cell: An emerging bioactive material with advanced applications in cancer theranostics

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
Artificial cells are emerging as attractive biomimetic bioactive materials that recapitulate key structures and functions of natural cells. This review systematically summarizes their major types, versatile fabrication strategies, tuneable properties and programmable biomimetic behaviours, highlights their cutting‐edge integrated applications in cancer
Daikun Wu, Shuo Yang, Hongjing Dou
wiley   +1 more source