Results 11 to 20 of about 596 (91)

Dissecting Shared Genetic Architecture of Thoracic Aortic Aneurysm and Aortic Related Traits and Identifying SplA /Ryanodine Receptor Domain and SOCS Box Containing 1 Involved in Smooth Muscle Phenotype Switching and Cell Senescence Through Alternative Splicing [PDF]

FASEB Journal
The flowchart of the study. BAPN, β‐aminopropionitrile; FUMA, Functional Mapping and Annotation; GO, Gene Ontology; GWAS, genome‐wide association study; KEGG, Kyoto encyclopedia of genes and genomes; LDSC, LD score regression; MR‐JTI, mendelian randomization joint‐tissue imputation; MTAG, multi‐trait analysis of GWAS; siRNA, small interfering RNA ...
Song Q, Chu T, Liu Q, Weng R, Li H, Liang M, Wu Z.   +6 more
exaly   +3 more sources

Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation [PDF]

PLoS ONE, 2017
Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution.
Zoltan Kutalik, Anne Justice, L Adrienne Cupples   +2 more
exaly   +2 more sources

GWAMA: A Web-Based Decision Support Tool for Greenwashing Risk Assessment in Sustainable Food Marketing

Sustainability
Greenwashing in food marketing undermines consumer trust and impedes Sustainable Development Goal 12 (SDG 12). While prior research has established linkages between greenwashing perception, green skepticism, and purchase intention, no publicly deployed decision support tool has been developed for practitioner use.
Danupol Hoonsopon, Wilert Puriwat
exaly   +2 more sources

Prediction of Episodic Memory With Multiomics Scores [PDF]

Biological Psychiatry Global Open Science
Matti Pirinen, Johan Gunnar Eriksson, Johannes Kettunen   +2 more
exaly   +2 more sources

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans

Frontiers in Genetics, 2021
Background: White blood cell (WBC) traits and their subtypes such as basophil count (Bas), eosinophil count (Eos), lymphocyte count (Lym), monocyte count (Mon), and neutrophil counts (Neu) are known to be associated with diseases such as stroke ...
Opeyemi Soremekun, Chisom Soremekun, Chisom Soremekun, Tafadzwa Machipisa, Tafadzwa Machipisa, Mahmoud Soliman, Oyekanmi Nashiru, Tinashe Chikowore, Tinashe Chikowore, Segun Fatumo, Segun Fatumo, Segun Fatumo   +11 more
doaj   +1 more source

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization

Arthritis &Rheumatology, Volume 75, Issue 10, Page 1781-1792, October 2023., 2023
Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods A genome‐wide association study meta‐analysis was performed of circulating sclerostin levels in 33,961 European individuals.
Jie Zheng, Eleanor Wheeler, Maik Pietzner, Till F. M. Andlauer, Michelle S. Yau, April E. Hartley, Ben Michael Brumpton, Humaira Rasheed, John P. Kemp, Monika Frysz, Jamie Robinson, Sjur Reppe, Vid Prijatelj, Kaare M. Gautvik, Louise Falk, Winfried Maerz, Ingrid Gergei, Patricia A. Peyser, Maryam Kavousi, Paul S. de Vries, Clint L. Miller, Maxime Bos, Sander W. van der Laan, Rajeev Malhotra, Markus Herrmann, Hubert Scharnagl, Marcus Kleber, George Dedoussis, Eleftheria Zeggini, Maria Nethander, Claes Ohlsson, Mattias Lorentzon, Nick Wareham, Claudia Langenberg, Michael V. Holmes, George Davey Smith, Jonathan H. Tobias   +36 more
wiley   +1 more source

X‐Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease

Movement Disorders, Volume 38, Issue 9, Page 1625-1635, September 2023., 2023
Abstract Background Sex differences in Parkinson's disease (PD) risk are well‐known. However, the role of sex chromosomes in the development and progression of PD is still unclear. Objective The objective of this study was to perform the first X‐chromosome–wide association study for PD risk in a Latin American cohort.
Thiago P. Leal, Shilpa C. Rao, Jennifer N. French‐Kwawu, Mateus H. Gouveia, Victor Borda, Sara Bandres‐Ciga, Miguel Inca‐Martinez, Emily A. Mason, Andrea R.V.R. Horimoto, Douglas P. Loesch, Elif I. Sarihan, Mario R. Cornejo‐Olivas, Luis E. Torres, Pilar E. Mazzetti‐Soler, Carlos Cosentino, Elison H. Sarapura‐Castro, Andrea Rivera‐Valdivia, Angel C. Medina, Elena M. Dieguez, Víctor E. Raggio, Andrés Lescano, Vitor Tumas, Vanderci Borges, Henrique B. Ferraz, Carlos R. Rieder, Artur Schumacher Schuh, Bruno L. Santos‐Lobato, Carlos Velez‐Pardo, Marlene Jimenez‐Del‐Rio, Francisco Lopera, Sonia Moreno, Pedro Chana‐Cuevas, William Fernandez, Gonzalo Arboleda, Humberto Arboleda, Carlos E. Arboleda Bustos, Dora Yearout, Maira T. Barbosa, Francisco E.C. Cardoso, Paulo Caramelli, Mauro C.Q. Cunningham, Débora P. Maia, Maria F. Lima‐Costa, Eduardo Tarazona‐Santos, Cyrus P. Zabetian, International Parkinson Disease Genomics Consortium (IPDGC), Timothy A. Thornton, Timothy D. O'Connor, Ignacio F. Mata, on behalf of the Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE‐PD)   +49 more
wiley   +1 more source

Sex‐ and APOE‐specific genetic risk factors for late‐onset Alzheimer's disease: Evidence from gene–gene interaction of longevity‐related loci

Aging Cell, Volume 22, Issue 9, September 2023., 2023
Genetic studies over the last few years, have changed the perception of late‐onset Alzheimer's disease (LOAD), highlighting its polygenic nature with multiple susceptibility genetic loci. We applied a multidimensional reduction approach to detect gene–gene interactions affecting LOAD by testing variants harbored by genes previously investigated in ...
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni   +9 more
wiley   +1 more source

APOE, ABCA7, and RASGEF1C are associated with earlier onset of amyloid deposition from more than 4000 harmonized positron emission tomography images. [PDF]

Alzheimers Dement
Abstract INTRODUCTION New methods estimate amyloid positivity onset age (EAOA) from amyloid positron emission tomography (PET). We explore the genetics of EAOA to identify molecular factors underlying the earliest Alzheimer's disease (AD) changes. METHODS Harmonized amyloid PET data from 4216 participants were used in genome‐wide survival, tissue ...
Castellano T, Wang TC, Nolan E, Wu Y, Zhang M, Clifton M, Janve VA, Durant A, Regelson A, Cody K, Harrison T, Engelman CD, Jagust W, Albert M, Johnson S, Resnick SM, Sperling R, Bilgel M, Saykin A, Vardarajan B, Mayeux R, Alzheimer's Disease Neuroimaging Initiative, Betthauser T, Bennett DA, Schneider J, De Jager P, Menon V, Tosun D, Mormino E, Archer DB, Dumitrescu L, Hohman TJ, Koran ME.   +32 more
europepmc   +2 more sources

Including diverse and admixed populations in genetic epidemiology research

Genetic Epidemiology, Volume 46, Issue 7, Page 347-371, October 2022., 2022
Abstract The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the Ethical, Legal, Social, Implications (ELSI) committee of the International Genetic Epidemiology Society (IGES) offer perspectives on methods and ...
Amke Caliebe, Fasil Tekola‐Ayele, Burcu F. Darst, Xuexia Wang, Yeunjoo E. Song, Jiang Gui, Ronnie A. Sebro, David J. Balding, Mohamad Saad, Marie‐Pierre Dubé, IGES ELSI Committee   +10 more
wiley   +1 more source