Results 41 to 50 of about 748 (103)

A meta‐analysis and polygenic score study identifies novel genetic markers for waist‐hip ratio in African populations

Obesity, Volume 32, Issue 11, Page 2175-2185, November 2024.
Abstract Objective Understanding the genetic underpinnings of anthropometric traits in diverse populations is crucial for gaining insights into their biological mechanisms and potential implications for health. Methods We conducted a genome‐wide association study, meta‐analysis, and gene set analysis of waist‐hip ratio (WHR), WHR adjusted for BMI ...
Michael Zhong, Ebuka Onyenobi, Ayo Duomatey, Guanjie Chen, James Perry, Zhenyao Ye, ACCME Research Group as part of the H3Africa Consortium, Charles Rotimi, Clement A. Adebamowo, Adebowale Adeyemo, Sally N. Adebamowo   +10 more
wiley   +1 more source

Electroacupuncture regulates Rab5a‐mediating NGF transduction to improve learning and memory ability in the early stage of AD mice

CNS Neuroscience &Therapeutics, Volume 30, Issue 5, May 2024.
A diagram illustrating the mechanism of basal forebrain hippocampal circuit plasticity enhancement by EA treatment. Overexpression of Rab5a‐GTP in 5 × FAD mice promotes early endosome fusion and facilitates NGF/TrkA complexes containing endosome degradation, resulting in NGF signal loss and a decrease in basal forebrain hippocampal circuit plasticity ...
Jianhong Li, Minguang Yang, Yaling Dai, Xiaoqin Guo, Yanyi Ding, Xiaoling Li, Shenghang Zhang, Wenshan Xu, Lidian Chen, Jing Tao, Weilin Liu   +10 more
wiley   +1 more source

Sex‐specific genetic architecture of late‐life memory performance

Alzheimer's &Dementia, Volume 20, Issue 2, Page 1250-1267, February 2024.
Abstract BACKGROUND Women demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain unclear. METHODS We conducted the largest sex‐aware genetic study on late‐life memory to date (Nmales = 11,942; Nfemales = 15,641).
Jaclyn M. Eissman, Derek B. Archer, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse B. Mez, William S. Bush, Brian W. Kunkle, Adam C. Naj, Katherine A. Gifford, The Alzheimer's Disease Neuroimaging Initiative (ADNI) | Alzheimer's Disease Genetics Consortium (ADGC) | The Alzheimer's Disease Sequencing Project (ADSP), Michael L. Cuccaro, Carlos Cruchaga, Margaret A. Pericak‐Vance, Lindsay A. Farrer, Li‐San Wang, Gerard D. Schellenberg, Richard P. Mayeux, Jonathan L. Haines, Angela L. Jefferson, Walter A. Kukull, C. Dirk Keene, Andrew J. Saykin, Paul M. Thompson, Eden R. Martin, David A. Bennett, Lisa L. Barnes, Julie A. Schneider, Paul K. Crane, Timothy J. Hohman, Logan Dumitrescu   +32 more
wiley   +1 more source

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease

Alzheimer's &Dementia, Volume 20, Issue 2, Page 1268-1283, February 2024.
Abstract INTRODUCTION Although large‐scale genome‐wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline. METHODS We conducted a cross‐ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations ...
Derek B. Archer, Jaclyn M. Eissman, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse B. Mez, William S. Bush, Brian W. Kunkle, Adam C. Naj, Katherine A. Gifford, The Alzheimer's Disease Neuroimaging Initiative (ADNI), Alzheimer's Disease Genetics Consortium (ADGC), The Alzheimer's Disease Sequencing Project (ADSP), Michael L. Cuccaro, Margaret A. Pericak‐Vance, Lindsay A. Farrer, Li‐San Wang, Gerard D. Schellenberg, Richard P. Mayeux, Jonathan L. Haines, Angela L. Jefferson, Walter A. Kukull, C. Dirk Keene, Andrew J. Saykin, Paul M. Thompson, Eden R. Martin, David A. Bennett, Lisa L. Barnes, Julie A. Schneider, Paul K. Crane, Logan Dumitrescu, Timothy J. Hohman   +33 more
wiley   +1 more source

Identifying drivers of corporate social responsibility for community involvement [PDF]

, 2013
Organisations operate under unpredictable business environments. These business environments can be classified into internal and external environments.
Gwama, Mzwandile Sebastian
core  

Across-cohort QC analyses of GWAS summary statistics from complex traits. [PDF]

, 2017
Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires large genome-wide association
Zhu, Z.X., Wood, A.R., Trzaskowski, M., Croteau-Chonka, D.C., Wray, N.R., GIANT Consortium (Albrecht, E. ; Grallert, H. ; Lichtner, P. ; Müller-Nurasyid, M. ; Ried, J.S. ; Thorand, B. ; Gieger, C. ; Illig, T. ; Peters, A. ; Strauch, K. ; Wichmann, H.-E. ; Heid, I.M.), Hirschhorn, J.N., Yang, J.A., Kutalik, Z., Chen, G.B., Robinson, M.R., Winkler, T.W., Locke, A.E., Lee, S.H., Frayling, T.M., Loos, R.J., Day, F.R.   +16 more
core   +3 more sources

Factors affecting clinical teaching for pre-service nursing education in Kenya medical training college, Nairobi campus. [PDF]

, 2015
Training of health workforce is an important element in ensuring delivery of quality health care services. New options for the education and in-service training of health care workers are required to ensure effective preparation and to meet a country's ...
Mwatsahu, Francis Gwama
core  

Gwama, a little-known endangered language of Ethiopia : a sketch of its grammar and lexicon

, 2005
PL8021.E8, ISO 639-3 : kmq, Ethiopia ...
openaire   +1 more source

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry. [PDF]

Nat Commun, 2023
Kamiza AB, Touré SM, Zhou F, Soremekun O, Cissé C, Wélé M, Touré AM, Nashiru O, Corpas M, Nyirenda M, Crampin A, Shaffer J, Doumbia S, Zeggini E, Morris AP, Asimit JL, Chikowore T, Fatumo S.   +17 more
europepmc   +1 more source

PYRAMA: an open-source tool for advanced meta-analysis of genome wide association studies. [PDF]

Bioinformatics
Manios GA, Nteli S, Kontou PI, Bagos PG.
europepmc   +1 more source