Results 21 to 30 of about 596 (91)

Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling

Arthritis &Rheumatology, Volume 74, Issue 9, Page 1535-1543, September 2022., 2022
Objectives Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factors and pathways that differentiate PsA from cutaneous‐only psoriasis (PsC) and to evaluate the ...
Mehreen Soomro, Michael Stadler, Nick Dand, James Bluett, Deepak Jadon, Farideh Jalali‐najafabadi, Michael Duckworth, Pauline Ho, Helena Marzo‐Ortega, Philip S. Helliwell, Anthony W. Ryan, David Kane, Eleanor Korendowych, Michael A. Simpson, Jonathan Packham, Ross McManus, Cem Gabay, Céline Lamacchia, Michael J. Nissen, Matthew A. Brown, Suzanne M. M. Verstappen, Tjeerd Van Staa, Jonathan N. Barker, Catherine H. Smith, the BADBIR Study Group, Robert Chalmers, Carsten Flohr, Karen Watson, David Prieto‐Merino, Oras Alabas, Jonathan Barker, Gabrielle Becher, Anthony Bewley, David Burden, Simon Morrison, Phil Laws, Ian Evans, Christopher Griffiths, Shehnaz Ahmed, Brian Kirby, Elise Kleyn, Linda Lawson, Teena Mackenzie, Tess McPherson, Kathleen McElhone, Ruth Murphy, Anthony Ormerod, Caroline Owen, Nick Reynolds, Amir Rashid, Catherine Smith, Richard Warren, the BSTOP study group, David Burden, Catherine Smith, Stefan Siebert, Sara Brown, Helen McAteer, Julia Schofield, Nick Dand, Oliver FitzGerald, Neil McHugh, Richard B. Warren, John Bowes, Anne Barton   +64 more
wiley   +1 more source

Using Mendelian randomization to explore the gateway hypothesis: possible causal effects of smoking initiation and alcohol consumption on substance use outcomes

Addiction, Volume 117, Issue 3, Page 741-750, March 2022., 2022
Abstract Background and Aims Initial use of drugs such as tobacco and alcohol may lead to subsequent more problematic drug use—the ‘gateway’ hypothesis. However, observed associations may be due to a shared underlying risk factor, such as trait impulsivity. We used bidirectional Mendelian randomization (MR) to test the gateway hypothesis.
Zoe E. Reed, Robyn E. Wootton, Marcus R. Munafò   +2 more
wiley   +1 more source

Large‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity

Brain and Behavior, Volume 11, Issue 8, August 2021., 2021
We present the perspective of the ENIGMA‐EEG workgroup on our goal to elucidate the genetics of brain activity measured by electroencephalography. We explain the issues that arise when performing an international multicohort study and the solutions to these problems.
Dirk J. A. Smit, Ole A. Andreassen, Dorret I. Boomsma, Scott J. Burwell, David B. Chorlian, Eco J. C. de Geus, Torbjørn Elvsåshagen, Reyna L. Gordon, Jeremy Harper, Ulrich Hegerl, Tilman Hensch, William G. Iacono, Philippe Jawinski, Erik G. Jönsson, Jurjen J. Luykx, Cyrille L. Magne, Stephen M. Malone, Sarah E. Medland, Jacquelyn L. Meyers, Torgeir Moberget, Bernice Porjesz, Christian Sander, Sanjay M. Sisodiya, Paul M. Thompson, Catharina E. M. van Beijsterveldt, Edwin van Dellen, Marc Via, Margaret J. Wright   +27 more
wiley   +1 more source

Genome‐wide association studies of exacerbations in children using long‐acting beta2‐agonists

Pediatric Allergy and Immunology, Volume 32, Issue 6, Page 1197-1207, August 2021., 2021
Abstract Background Some children with asthma experience exacerbations despite long‐acting beta2‐agonist (LABA) treatment. While this variability is partly caused by genetic variation, no genome‐wide study until now has investigated which genetic factors associated with risk of exacerbations despite LABA use in children with asthma.
Elise M. A. Slob, Levi B. Richards, Susanne J. H. Vijverberg, Cristina Longo, Gerard H. Koppelman, Mariëlle W. H. Pijnenburg, Elisabeth H. D. Bel, Anne H. Neerincx, Esther Herrera Luis, Javier Perez‐Garcia, Fook Tim Chew, Yang Yie Sio, Anand K. Andiappan, Steve W. Turner, Somnath Mukhopadhyay, Colin N. A. Palmer, Daniel Hawcutt, Andrea L. Jorgensen, Esteban G. Burchard, Natalia Hernandez‐Pacheco, Maria Pino‐Yanes, Anke H. Maitland‐van der Zee, Ömer Kalaycı   +22 more
wiley   +1 more source

Trans‐ancestry GWAS for Alzheimer’s Disease Reveals a Novel Locus interacting with APOE*4 [PDF]

Alzheimers Dement
Abstract Background APOE*4 is the strongest genetic risk for late‐onset Alzheimer’s disease (AD), but other genetic loci may counter its detrimental effect, providing therapeutic avenues. Expanding beyond non‐Hispanic White subjects, we sought to additionally leverage genetic data from non‐Hispanic and Hispanic subjects of admixed African ancestry to ...
Belloy M, Reid D, Guen Y, Napolioni V, Greicius M.   +4 more
europepmc   +2 more sources

Sex‐stratified GWAS for Alzheimer’s Disease Reveals African Ancestry Risk variants in Men [PDF]

Alzheimers Dement
Abstract Background Several studies have indicated sex‐specific genetic risk for Alzheimer’s disease (AD), but these were centered on non‐Hispanic White individuals of European ancestry. We sought to identify sex‐specific genetic variants for AD in non‐Hispanic and Hispanic subjects of admixed African ancestry.
Belloy M, Reid D, Guen Y, Napolioni V, Greicius M.   +4 more
europepmc   +2 more sources

Double genomic control is not effective to correct for population stratification in Meta-analysis for genome-wide association studies

Frontiers in Genetics, 2012
Meta-analysis of genome-wide association studies (GWAS) has become a useful tool to identify genetic variants that are associated with complex human diseases.
Shudong eWang, Shudong eWang, Wenan eChen, Xiangning eChen, Fengjiao eHu, Kellie J. eArcher, Nianjun eLiu, Shumei eSun, Guimin eGao   +8 more
doaj   +1 more source

Transformative approaches to managing student unrest in a South African university

Interdisciplinary Journal of Management Sciences
Higher education and training institutions in South Africa have experienced widespread student unrest and crises in recent years, particularly within universities.
Unathi Mvuyisi Gwama
doaj   +1 more source

APOE*4 risk‐modifying genes and drug targets in Alzheimer's disease through cell‐type‐specific genomic analyses

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Genetics studies can identify drug targets that counteract the effects of the apolipoprotein E ε4 allele (APOE*4) on Alzheimer's disease (AD) but have remained limited in power and crucially did not assess genetic findings with regard to APOE*4's cell‐type‐specific impact on pathobiology.
Youjie Zeng, Noah Cook, Chenyu Yang, Sathesh K. Sivasankaran, Masashi Fujita, Zachary A. Gardell, Yann Le Guen, Daichi Shigemizu, Kouichi Ozaki, Takashi Morizono, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Cyril Pottier, Carlos Cruchaga, Valerio Napolioni, M. Ryan Corces, Vilas Menon, Michael D. Greicius, Michael E. Belloy   +19 more
wiley   +1 more source

Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification

International Journal of Cancer, Volume 158, Issue 11, Page 2866-2879, 1 June 2026.
What's new? Asbestos exposure is a major risk factor for pleural mesothelioma (PM). Most asbestos‐exposed individuals do not develop PM, suggesting that it arises from a complex interplay between environmental and genetic factors. This study examined the utility of polygenic risk scores (PRS) and methylation risk scores (MRS) in incorporating genetic ...
Khadija Sana Hafeez, Carla Debernardi, Alessandra Allione, Elton Jalis Herman, Simonetta Guarrera, Daniela Ferrante, Anna Aspesi, Marika Sculco, Marta La Vecchia, Carlotta Sacerdote, Federica Grosso, Christina M. Lill, Giovanna Masala, Marcela Guevara, Matthias B. Schulze, Salvatore Panico, Yaszan Asgari, Seehyun Park, Giovanna Tagliabue, Anne Tjønneland, Antonio Agudo, Elisabete Weiderpass, Corrado Magnani, Irma Dianzani, Paolo Vineis, Elisabetta Casalone, Giuseppe Matullo   +26 more
wiley   +1 more source