Results 21 to 30 of about 748 (103)
Sex‐ and APOE‐specific genetic risk factors for late‐onset Alzheimer's disease: Evidence from gene–gene interaction of longevity‐related loci
Aging Cell, Volume 22, Issue 9, September 2023., 2023 Genetic studies over the last few years, have changed the perception of late‐onset Alzheimer's disease (LOAD), highlighting its polygenic nature with multiple susceptibility genetic loci. We applied a multidimensional reduction approach to detect gene–gene interactions affecting LOAD by testing variants harbored by genes previously investigated in ...Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni +9 morewiley +1 more sourceIncluding diverse and admixed populations in genetic epidemiology research
Genetic Epidemiology, Volume 46, Issue 7, Page 347-371, October 2022., 2022 Abstract
The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the Ethical, Legal, Social, Implications (ELSI) committee of the International Genetic Epidemiology Society (IGES) offer perspectives on methods and ...Amke Caliebe, Fasil Tekola‐Ayele, Burcu F. Darst, Xuexia Wang, Yeunjoo E. Song, Jiang Gui, Ronnie A. Sebro, David J. Balding, Mohamad Saad, Marie‐Pierre Dubé, IGES ELSI Committee +10 morewiley +1 more sourceComparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling
Arthritis &Rheumatology, Volume 74, Issue 9, Page 1535-1543, September 2022., 2022 Objectives
Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factors and pathways that differentiate PsA from cutaneous‐only psoriasis (PsC) and to evaluate the ...Mehreen Soomro, Michael Stadler, Nick Dand, James Bluett, Deepak Jadon, Farideh Jalali‐najafabadi, Michael Duckworth, Pauline Ho, Helena Marzo‐Ortega, Philip S. Helliwell, Anthony W. Ryan, David Kane, Eleanor Korendowych, Michael A. Simpson, Jonathan Packham, Ross McManus, Cem Gabay, Céline Lamacchia, Michael J. Nissen, Matthew A. Brown, Suzanne M. M. Verstappen, Tjeerd Van Staa, Jonathan N. Barker, Catherine H. Smith, the BADBIR Study Group, Robert Chalmers, Carsten Flohr, Karen Watson, David Prieto‐Merino, Oras Alabas, Jonathan Barker, Gabrielle Becher, Anthony Bewley, David Burden, Simon Morrison, Phil Laws, Ian Evans, Christopher Griffiths, Shehnaz Ahmed, Brian Kirby, Elise Kleyn, Linda Lawson, Teena Mackenzie, Tess McPherson, Kathleen McElhone, Ruth Murphy, Anthony Ormerod, Caroline Owen, Nick Reynolds, Amir Rashid, Catherine Smith, Richard Warren, the BSTOP study group, David Burden, Catherine Smith, Stefan Siebert, Sara Brown, Helen McAteer, Julia Schofield, Nick Dand, Oliver FitzGerald, Neil McHugh, Richard B. Warren, John Bowes, Anne Barton +64 morewiley +1 more sourceLarge‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity
Brain and Behavior, Volume 11, Issue 8, August 2021., 2021 We present the perspective of the ENIGMA‐EEG workgroup on our goal to elucidate the genetics of brain activity measured by electroencephalography. We explain the issues that arise when performing an international multicohort study and the solutions to these problems.Dirk J. A. Smit, Ole A. Andreassen, Dorret I. Boomsma, Scott J. Burwell, David B. Chorlian, Eco J. C. de Geus, Torbjørn Elvsåshagen, Reyna L. Gordon, Jeremy Harper, Ulrich Hegerl, Tilman Hensch, William G. Iacono, Philippe Jawinski, Erik G. Jönsson, Jurjen J. Luykx, Cyrille L. Magne, Stephen M. Malone, Sarah E. Medland, Jacquelyn L. Meyers, Torgeir Moberget, Bernice Porjesz, Christian Sander, Sanjay M. Sisodiya, Paul M. Thompson, Catharina E. M. van Beijsterveldt, Edwin van Dellen, Marc Via, Margaret J. Wright +27 morewiley +1 more sourceGenome‐wide association studies of exacerbations in children using long‐acting beta2‐agonists
Pediatric Allergy and Immunology, Volume 32, Issue 6, Page 1197-1207, August 2021., 2021 Abstract Background
Some children with asthma experience exacerbations despite long‐acting beta2‐agonist (LABA) treatment. While this variability is partly caused by genetic variation, no genome‐wide study until now has investigated which genetic factors associated with risk of exacerbations despite LABA use in children with asthma.Elise M. A. Slob, Levi B. Richards, Susanne J. H. Vijverberg, Cristina Longo, Gerard H. Koppelman, Mariëlle W. H. Pijnenburg, Elisabeth H. D. Bel, Anne H. Neerincx, Esther Herrera Luis, Javier Perez‐Garcia, Fook Tim Chew, Yang Yie Sio, Anand K. Andiappan, Steve W. Turner, Somnath Mukhopadhyay, Colin N. A. Palmer, Daniel Hawcutt, Andrea L. Jorgensen, Esteban G. Burchard, Natalia Hernandez‐Pacheco, Maria Pino‐Yanes, Anke H. Maitland‐van der Zee, Ömer Kalaycı +22 morewiley +1 more sourceAPOE, ABCA7, and RASGEF1C are associated with earlier onset of amyloid deposition from more than 4000 harmonized positron emission tomography images. [PDF]
Alzheimers DementAbstract INTRODUCTION
New methods estimate amyloid positivity onset age (EAOA) from amyloid positron emission tomography (PET). We explore the genetics of EAOA to identify molecular factors underlying the earliest Alzheimer's disease (AD) changes. METHODS
Harmonized amyloid PET data from 4216 participants were used in genome‐wide survival, tissue ...Castellano T, Wang TC, Nolan E, Wu Y, Zhang M, Clifton M, Janve VA, Durant A, Regelson A, Cody K, Harrison T, Engelman CD, Jagust W, Albert M, Johnson S, Resnick SM, Sperling R, Bilgel M, Saykin A, Vardarajan B, Mayeux R, Alzheimer's Disease Neuroimaging Initiative, Betthauser T, Bennett DA, Schneider J, De Jager P, Menon V, Tosun D, Mormino E, Archer DB, Dumitrescu L, Hohman TJ, Koran ME. +32 moreeuropepmc +2 more sourcesA central role for GRB10 in regulation of islet function in man [PDF]
, 2014 Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably ...Osmond, C, Kang, HM, Ahlqvist, Emma,, Eriksson, Johan G, Tove Fall, Benjamin F Voight, Paul A. Blomstedt (434502), Lakka, T.A., Salehi, S. Albert, Rainer Rauramaa, Liu, Jie, Mark Walker, McCarthy, Mark I, Blomstedt, P.A., Ann-Christine Syvänen, Liu, J., Tonjes, A., Valeriya Lyssenko (11998), Timo A Lakka, Philippe Froguel (2247), Groop, L, Isomaa, B., Jeffrey R O'Connell, Jackson, Anne U., Fadista, J., Jackson, AU, Cecile Lecoeur, Joao Fadista (2795668), Emma Ahlqvist (135003), Tönjes, A, Kuusisto, J, Hansson, Karin B, Tiinamaija Tuomi, Ola Hansson (88199), Wenny Poon, Karin Hansson, Ola Hansson, Elisabeth Widen (75580), Stančáková, A, Lyssenko, V., Langenberg, C, Yu-Ching Cheng (546877), Johanna Kuusisto (197767), Jalal Taneera, Tove Fall (201258), Groop, L., Shuldiner, Alan R., Wierup, N., Bouatia-Naji, Nabila, Ruth J. F. Loos (110224), Tönjes, Anke, Walker, M, Loos, Ruth J F, Anke Tönjes (103703), Widen, E., Langenberg, Claudia, Vasiliki Lagou (149920), Blomstedt, Paul A, Voight, Benjamin F, Jeffrey R. O'Connell (170220), Eriksson, Johan G., Charlotte Ling, Wierup, Nils,, Frayling, Timothy M., Prasad, RB, Erik Ingelsson, Almgren, P., Nilsson, Peter, Michael N. Weedon (160690), Jie Liu (15128), Palotie, Aarno, Michael Stumvoll, Nabila Bouatia-Naji (149349), Liu, J, Ashish Kumar (152984), Weijia Xie (546876), Vatin, V, Fall, Tove, Hyun Min Kang (145687), Ahlqvist, E., Mark I. McCarthy (145748), Voight, BF, Lagou, Vasiliki, Voight, Benjamin F., Charlotte Ling (253302), Alan R Shuldiner, Jalal Taneera (546879), Ling, Charlotte,, Jari Lahti, Weijia Xie, Isomaa, B, Rauramaa, R, Inga Prokopenko, Kumar, A, Markku Laakso, Salehi, S.A., Stumvoll, M, Maegi, R, Wareham, Nicholas J, Anke Tönjes, Aarno Palotie (41342), Salehi, SA, Eriksson, JG, Palotie, A, Groop, Leif,, Blomstedt, PA, Timothy M Frayling, Bo Isomaa (68893), Poon, Wenny,, Almgren, Peter, Syvänen, Ann-Christine, Cheng, YC, Karin Hansson (546880), Levy-Marchal, C., Ong, KK, Lahti, Jari, Xie, Weijia, Laakso, M, Maegi, Reedik, F Voight, Benjamin,, Dayeh, T, Osmark, P., Alkayyali, S., Ingelsson, Erik, Johan G. Eriksson (150122), Rashmi Prasad B, Vatin, Vincent, Ling, Charlotte, Osmark, Peter,, Magi, R., Salehi, S Albert, Levy-Marchal, Claire, Silver, Kristi D, Ashish Kumar, Ling, C, Widen, Elisabeth, Walker, Mark, McCarthy, MI, Nilsson, P, Shuldiner, A.R., Peter Nilsson (3305), Hansson, Karin, Fall, Tove,, Hansson, O., Andrea Mari (297970), Palotie, A., Blomstedt, Paul A., Prasad B, Rashmi, Wierup, Nils, Lecoeur, C., Kristi D. Silver (546881), Lagou, V., Levy-Marchal, C, Kovacs, P, Isomaa, Bo, Prokopenko, Inga, Fadista, J, Joao Fadista, Wenny Poon (546872), Hansson, Ola,, Stančáková, Alena, Johanna Kuusisto, Alkayyali, Sami,, Lakka, Timo A., McCarthy, Mark I., Silver, Kristi D., Timo A. Lakka (198694), Clive Osmond (286037), Frayling, Timothy M, Lakka, TA, Cecile Lecoeur (4429696), Reedik Mägi (667294), Poon, Wenny, Claire Levy-Marchal, Ong, K.K., Alkayyali, Sami, Taneera, Jalal,, Kang, H.M., Dayeh, Tasnim, Tasnim Dayeh (428020), Wareham, N.J., Weedon, Michael N., F Voight, Benjamin, Vincent Vatin (116624), Sami Alkayyali, Vatin, V., Ong, Ken K, Almgren, Peter,, Lahti, J, Nicholas J Wareham, Tiinamaija Tuomi (12004), Claudia Langenberg, Peter Almgren, Andrea Mari, Prokopenko, I, Dayeh, T., Valeriya Lyssenko, Almgren, P, Tuomi, Tiinamaija,, Lyssenko, Valeriya, Lecoeur, Cecile, Jari Lahti (149903), Timothy M. Frayling (145700), Alkayyali, S, Loos, Ruth J. F., Kovacs, P., Lakka, Timo A, Inga Prokopenko (43252), S Albert Salehi, Langenberg, C., Laakso, M., Lyssenko, V, Prasad, Rashmi B., McCarthy, Mark, Kuusisto, J., Nils Wierup, Cheng, Yu-Ching, Taneera, Jalal, Kovacs, Peter, Loos, RJF, Lahti, J., Jackson, A.U., Reedik Mägi, Prokopenko, I., Lund University., Michael N Weedon, Weedon, Michael N, Ken K. Ong (188600), Mägi, Reedik, Nilsson, Peter,, Hansson, K., Voight, B.F., Mägi, R, Hansson, Ola, Cheng, Y-C, Xie, W, S. Albert Salehi (546874), Syvänen, Ann-Christine,, Johan G Eriksson, Prasad, B.R., Kristi D Silver, Kumar, Ashish, Yu-Ching Cheng, Markku Laakso (197777), Prasad B, R, Aarno Palotie, Vasiliki Lagou, Jie Liu, Ling, C., Xie, W., Ann-Christine Syvänen (57309), Nils Wierup (167236), Hansson, Karin B,, Loos, RJ, Prasad, Rashmi,, Fall, T, Wareham, NJ, Anne U. Jackson (145702), Philippe Froguel, Syvanen, A-C, Frayling, TM, Shuldiner, Alan R, Barker, A, Syvanen, A.C., Kuusisto, Johanna, Emma Ahlqvist, McCarthy, M.I., Hyun Min Kang, Weedon, MN, Ruth J F Loos, Fadista, Joao,, Ong, Ken K., Silver, K.D., Tasnim Dayeh, Taneera, J., Claudia Langenberg (160616), Rainer Rauramaa (211915), Mark Walker (21700), Barker, A., Eriksson, J.G., Vincent Vatin, Adam Barker, Sami Alkayyali (546878), Stumvoll, M., Walker, M., Ken K Ong, Salehi, S Albert,, Lagou, V, Tuomi, T, Alena Stančáková (197764), Osmark, P, Syvänen, AC, Jackson, Anne U, Inglesson, E., Peter Osmark (375761), Mari, Andrea, O'Connell, J.R., Wareham, Nicholas J., Shuldiner, AR, Peter Kovacs (103720), Dayeh, Tasnim,, Stancakova, A., Rashmi Prasad B (546873), Mari, A., Adam Barker (546875), Rauramaa, Rainer, Frayling, T.M., Stumvoll, Michael, Loos, R.J., Bouatia-Naji, N., Osmond, Clive, Mari, A, Froguel, Philippe, Wierup, N, Alena Stančáková, Peter Nilsson, Benjamin F. Voight (145685), Alan R. Shuldiner (110828), Paul A Blomstedt, Fall, T., Silver, KD, Nabila Bouatia-Naji, Mark I McCarthy, Kumar, A., Osmark, Peter, Bouatia-Naji, N, Widen, E, Poon, W, Nilsson, P., Fadista, Joao, Prasad, Rashmi, Palotie, Aarno,, Ingelsson, Erik,, Tuomi, T., Poon, W., Ingelsson, E, Weedon, M.N., Laakso, Markku, O'Connell, JR, Claire Levy-Marchal (76792), O'Connell, Jeffrey R., Lecoeur, C, Leif Groop, Hansson, O, Groop, Leif, Elisabeth Widen, Rauramaa, R., Taneera, J, Hansson, K, Peter Osmark, Peter Almgren (11999), O'Connell, Jeffrey R, Kang, Hyun Min, Ahlqvist, E, Froguel, P., Erik Ingelsson (232651), Peter Kovacs, Michael Stumvoll (103716), Bo Isomaa, Clive Osmond, Cheng, Y.C., Anne U Jackson, Nicholas J. Wareham (110277), Leif Groop (12005), Froguel, P, Ahlqvist, Emma, Barker, Adam, Tuomi, Tiinamaija, Lyssenko, Valeriya, +368 morecore +1 more source
