Results 31 to 40 of about 748 (103)

Trans‐ancestry GWAS for Alzheimer’s Disease Reveals a Novel Locus interacting with APOE*4 [PDF]

open access: yesAlzheimers Dement
Abstract Background APOE*4 is the strongest genetic risk for late‐onset Alzheimer’s disease (AD), but other genetic loci may counter its detrimental effect, providing therapeutic avenues. Expanding beyond non‐Hispanic White subjects, we sought to additionally leverage genetic data from non‐Hispanic and Hispanic subjects of admixed African ancestry to ...
Belloy M   +4 more
europepmc   +2 more sources

Sex‐stratified GWAS for Alzheimer’s Disease Reveals African Ancestry Risk variants in Men [PDF]

open access: yesAlzheimers Dement
Abstract Background Several studies have indicated sex‐specific genetic risk for Alzheimer’s disease (AD), but these were centered on non‐Hispanic White individuals of European ancestry. We sought to identify sex‐specific genetic variants for AD in non‐Hispanic and Hispanic subjects of admixed African ancestry.
Belloy M   +4 more
europepmc   +2 more sources

Most significant BMI x SNP interaction terms for urate GWAMA.

open access: yes, 2015
A1, allele for which effect (β) is reported; A2 alternate allele, fqA1 weighted average effect-allele frequency across studies meta-analyzed; s.e. standard error of the effect estimate, I2 meta-analysis heterogeneity statistic.
Matthias Nauck (112743)   +119 more
core   +1 more source

APOE*4 risk‐modifying genes and drug targets in Alzheimer's disease through cell‐type‐specific genomic analyses

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Genetics studies can identify drug targets that counteract the effects of the apolipoprotein E ε4 allele (APOE*4) on Alzheimer's disease (AD) but have remained limited in power and crucially did not assess genetic findings with regard to APOE*4's cell‐type‐specific impact on pathobiology.
Youjie Zeng   +19 more
wiley   +1 more source

Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification

open access: yesInternational Journal of Cancer, Volume 158, Issue 11, Page 2866-2879, 1 June 2026.
What's new? Asbestos exposure is a major risk factor for pleural mesothelioma (PM). Most asbestos‐exposed individuals do not develop PM, suggesting that it arises from a complex interplay between environmental and genetic factors. This study examined the utility of polygenic risk scores (PRS) and methylation risk scores (MRS) in incorporating genetic ...
Khadija Sana Hafeez   +26 more
wiley   +1 more source

Methods for multiancestry genome‐wide association study meta‐analysis

open access: yesAnnals of Human Genetics, Volume 89, Issue 5, Page 255-263, September 2025.
Abstract Genome‐wide association studies (GWAS) have significantly enhanced our understanding of the genetic basis of complex diseases. Despite the technological advancements, gaps in our understanding remain, partly due to small effect sizes and inadequate coverage of genetic variation.
Chuan Fu Yap, Andrew P. Morris
wiley   +1 more source

6Explaining weak financial development in Africa [PDF]

open access: yes, 2015
This study seeks to determine the causes of weakness in financial system development on the African continent. The research specifically investigates whether endowments theory, inequality, openness and remittances explain Africa’s financial (under ...
Michael Gwama, Gwama, M
core  

Investigating the Income Generating Activity Fund (IGA) and its effect on women entrepreneurs in Windhoek Namibia

open access: yes, 2022
A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Business Administration EntrepreneurshipThe purpose of this study was to establish how the Income Generating Activities fund (!GA) has impacted women entrepreneurs
Gwama, Josephine Nombeko
core  

Whole-genome sequence-based analysis of thyroid function. [PDF]

open access: yes, 2015
Normal thyroid function is essential for health, but its genetic architecture remains poorly understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4), we analyse whole-genome sequence data from the UK10K project (N=2 ...
Paternoster, Lavinia   +635 more
core   +1 more source

Managing student unrest in a South African university: a case study

open access: yes, 2022
Dissertation (M.Ed.(Education Management and Leadership))--University of the Free State, 2022Higher education and training institutions in South Africa have been plagued by nationwide student unrest and crises for the past few years.
Gwama, Unathi Mvuyisi
core   +2 more sources

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