Results 1 to 10 of about 247,905 (333)

Analyzing genome-wide association studies with an FDR controlling modification of the Bayesian information criterion [PDF]

, 2014
The prevailing method of analyzing GWAS data is still to test each marker individually, although from a statistical point of view it is quite obvious that in case of complex traits such single marker tests are not ideal.
Bodenstorfer, Bernhard, Dolejsi, Erich, Frommlet, Florian   +2 more
core   +26 more sources

BTOB: Extending the Biased GWAS to Bivariate GWAS [PDF]

Frontiers in Genetics, 2021
In recent years, a number of literatures published large-scale genome-wide association studies (GWASs) for human diseases or traits while adjusting for other heritable covariate. However, it is known that these GWASs are biased, which may lead to biased genetic estimates or even false positives.
Zhu, Junxian, Fan, Qiao, Deng, Wenying, Wang, Yimeng, Guo, Xiaobo   +4 more
openaire   +3 more sources

GWAS of Hematuria

Clinical Journal of the American Society of Nephrology, 2022
Background and objectives Glomerular hematuria has varied causes but can have a genetic basis, including Alport syndrome and IgA nephropathy. Design, setting, participants, & measurements We used summary statistics to identify genetic variants associated with hematuria in White ...
Sarah A. Gagliano Taliun, Patrick Sulem, Gardar Sveinbjornsson, Daniel F. Gudbjartsson, Kari Stefansson, Andrew D. Paterson, Moumita Barua   +6 more
openaire   +2 more sources

Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidence

Canadian Journal of Pain, 2021
Background Chronic postsurgical pain (CPSP) in children remains an important problem with no effective preventive or therapeutic strategies. Recently, genomic underpinnings explaining additional interindividual risk beyond psychological factors have been
Adam. J. Dourson, Adam. Willits, Namrata.G.R. Raut, Leena Kader, Erin Young, Michael.P. Jankowski, Vidya Chidambaran   +6 more
doaj   +1 more source

Resequencing of 558 Chinese mungbean landraces identifies genetic loci associated with key agronomic traits

Frontiers in Plant Science, 2022
Mungbean is a warm-season annual food legume and plays important role in supplying food and nutritional security in many tropical countries. However, the genetic basis of its agronomic traits remains poorly understood.
Xuesong Han, Li Li, Hongwei Chen, Liangjun Liu, Longqin Sun, Xingmin Wang, Yantao Xiang, Zhenghuang Wan, Changyan Liu   +8 more
doaj   +1 more source

High-Throughput Genome-Wide Genotyping To Optimize the Use of Natural Genetic Resources in the Grassland Species Perennial Ryegrass (Lolium perenne L.)

G3: Genes, Genomes, Genetics, 2020
The natural genetic diversity of agricultural species is an essential genetic resource for breeding programs aiming to improve their ecosystem and production services.
Thomas Keep, Jean-Paul Sampoux, José Luis Blanco-Pastor, Klaus J. Dehmer, Matthew J. Hegarty, Thomas Ledauphin, Isabelle Litrico, Hilde Muylle, Isabel Roldán-Ruiz, Anna M. Roschanski, Tom Ruttink, Fabien Surault, Evelin Willner, Philippe Barre   +13 more
doaj   +1 more source

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. [PDF]

, 2020
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP)
Aldana, Ileana, Araya, Carmen, Araya, Xinia, Bearden, Carrie E, Bedoya, Gabriel, Bejarano, Julio, Cantor, Rita M, Castrillón, Gabriel, Coppola, Giovanni, Escobar, Javier I, Fears, Scott C, Freimer, Nelson B, Gomez-Makhinson, Juliana, Huang, Alden Y, Hwang, Sun-Goo, Kremeyer, Barbara, Lopez, Maria C, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Montoya, Claudia P, Montoya, Gabriel, Mullins, Niamh, Olde Loohuis, Loes M, Ophoff, Roel A, Ori, Anil PS, Ospina-Duque, Jorge, Park, YoungJun, Ramensky, Vasily, Ramirez, Margarita, Reus, Victor, Ruiz-Linares, Andres, Sabatti, Chiara, Service, Susan K, Spesny, Mitzi, Sul, Jae Hoon, Teshiba, Terri M, Zhang, Zhongyang   +37 more
core   +3 more sources

Reducing GWAS Complexity [PDF]

Cell Cycle, 2016
Genome-wide association studies (GWAS) have revealed numerous genomic 'hits' associated with complex phenotypes. In most cases these hits, along with surrogate genetic variation as measure by numerous single nucleotide polymorphisms (SNPs) that are in linkage disequilibrium, are not in coding genes making assignment of functionality or causality ...
Dennis J, Hazelett, David V, Conti, Ying, Han, Ali Amin, Al Olama, Doug, Easton, Rosalind A, Eeles, Zsofia, Kote-Jarai, Christopher A, Haiman, Gerhard A, Coetzee   +8 more
openaire   +2 more sources

Genome wide association study of growth and feed efficiency traits in rabbits

World Rabbit Science, 2023
Feed efficiency is a major production trait in animal genetic breeding schemes. To further investigate the genetic control of feed efficiency in rabbits, we performed a genome-wide association study (GWAS) for growth and feed efficiency on 679 rabbits ...
Hervé Garreau, Yann Labrune, Hervé Chapuis, Julien Ruesche, Juliette Riquet, Julie Demars, Florence Benitez, François Richard, Laurence Drouilhet, Olivier Zemb, Hélène Gilbert   +10 more
doaj   +1 more source

Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes

Exploration of Medicine, 2021
Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden.
Richard Sherva, Congcong Zhu, Leah Wetherill, Howard J. Edenberg, Emma Johnson, Louisa Degenhardt, Arpana Agrawal, Nicholas G. Martin, Elliot Nelson, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer   +11 more
doaj   +1 more source