Results 1 to 10 of about 283,327 (339)

Unifying candidate gene and GWAS Approaches in Asthma. [PDF]

, 2010
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS ...
Berg, Andrea von, Bufe, Albrecht, Depner, Martin, Frischer, Thomas, Genuneit, Jon, Gut, Ivo G., Heinzmann, Andrea, Illig, Thomas, Kabesch, Michael, Klopp, Norman, Kumar, Ashish, Lathrop, Mark, Laub, Otto, Liang, Liming, Michel, Sven, Mutius, Erika von, Rietschel, Ernst, Ruether, Andreas, Schedel, Michaela, Schreiber, Stefan, Simma, Burkhard, Vogelberg, Christian   +21 more
core   +17 more sources

Impact of control selection strategies on GWAS results: a study of prostate cancer in the UK Biobank [PDF]

Lu J, Thygesen JH, Beaumont RN, Weedon MN, Green H.   +4 more
europepmc   +2 more sources

Genome wide association study of growth and feed efficiency traits in rabbits

World Rabbit Science, 2023
Feed efficiency is a major production trait in animal genetic breeding schemes. To further investigate the genetic control of feed efficiency in rabbits, we performed a genome-wide association study (GWAS) for growth and feed efficiency on 679 rabbits ...
Hervé Garreau, Yann Labrune, Hervé Chapuis, Julien Ruesche, Juliette Riquet, Julie Demars, Florence Benitez, François Richard, Laurence Drouilhet, Olivier Zemb, Hélène Gilbert   +10 more
doaj   +1 more source

Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidence

Canadian Journal of Pain, 2021
Background Chronic postsurgical pain (CPSP) in children remains an important problem with no effective preventive or therapeutic strategies. Recently, genomic underpinnings explaining additional interindividual risk beyond psychological factors have been
Adam. J. Dourson, Adam. Willits, Namrata.G.R. Raut, Leena Kader, Erin Young, Michael.P. Jankowski, Vidya Chidambaran   +6 more
doaj   +1 more source

Functional analysis and signaling pathway enrichment analysis of genes associated with Alzheimer’s disease and Parkinson’s disease

Бюллетень сибирской медицины, 2020
We identified significant functions of susceptibility-genes and performed an analysis of pathway enrichment for Alzheimer’s disease, Parkinson’s disease and for both of them.
N. Yu. Chasovskikh, A. Yu. Grechishnikova, D. V. Smirnov   +2 more
doaj   +1 more source

Features of functional annotation of rheumatoid arthritis susceptibility genes by Cytoscape

Бюллетень сибирской медицины, 2020
Aim. To evaluate the functional annotation of genes associated with rheumatoid arthritis with different parameters of the ClueGO Cytoscape tool.Materials and methods.
N. Yu. Chasovskikh
doaj   +1 more source

Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

Human Vaccines & Immunotherapeutics, 2023
In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors.
Jennifer Connors, Gina Cusimano, Nathan Mege, Kyra Woloszczuk, Emily Konopka, Matthew Bell, David Joyner, Jennifer Marcy, Virginie Tardif, Michele A. Kutzler, Roshell Muir, Elias K. Haddad   +11 more
doaj   +1 more source

Resequencing of 558 Chinese mungbean landraces identifies genetic loci associated with key agronomic traits

Frontiers in Plant Science, 2022
Mungbean is a warm-season annual food legume and plays important role in supplying food and nutritional security in many tropical countries. However, the genetic basis of its agronomic traits remains poorly understood.
Xuesong Han, Li Li, Hongwei Chen, Liangjun Liu, Longqin Sun, Xingmin Wang, Yantao Xiang, Zhenghuang Wan, Changyan Liu   +8 more
doaj   +1 more source

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. [PDF]

, 2020
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP)
Aldana, Ileana, Araya, Carmen, Araya, Xinia, Bearden, Carrie E, Bedoya, Gabriel, Bejarano, Julio, Cantor, Rita M, Castrillón, Gabriel, Coppola, Giovanni, Escobar, Javier I, Fears, Scott C, Freimer, Nelson B, Gomez-Makhinson, Juliana, Huang, Alden Y, Hwang, Sun-Goo, Kremeyer, Barbara, Lopez, Maria C, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Montoya, Claudia P, Montoya, Gabriel, Mullins, Niamh, Olde Loohuis, Loes M, Ophoff, Roel A, Ori, Anil PS, Ospina-Duque, Jorge, Park, YoungJun, Ramensky, Vasily, Ramirez, Margarita, Reus, Victor, Ruiz-Linares, Andres, Sabatti, Chiara, Service, Susan K, Spesny, Mitzi, Sul, Jae Hoon, Teshiba, Terri M, Zhang, Zhongyang   +37 more
core   +2 more sources

Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes

Exploration of Medicine, 2021
Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden.
Richard Sherva, Congcong Zhu, Leah Wetherill, Howard J. Edenberg, Emma Johnson, Louisa Degenhardt, Arpana Agrawal, Nicholas G. Martin, Elliot Nelson, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer   +11 more
doaj   +1 more source