Results 151 to 160 of about 247,905 (333)

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

Distribution of rs6795970 SNP variants in SCN10A gene in young population of the Republic of Moldova.

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2020
Background. PR interval reflects atrial and atrioventricular nodal conduction time and is an important determinant of arrhythmia risk. Genome-wide association studies (GWAS) have identified association of nonsynonymous SNP, rs6795970, in the SCN10A gene ...
Cristina Butovscaia, Anastasia Buza, Daniela Abduşa, G. Kurochkin   +3 more
doaj  

Candidates for tumor PAI: recurrent SCNA loci from TCGA that overlap cancer-associated SNPs (NHGRI GWAS Catalog) identified in matching tumor types.

, 2015
Jonathan Adam, M. Walsh Kyle, M. Hansen Helen, A. Endicott Alyson, K. Wiencke John, Metayer Catherine, Lavania Joseph   +6 more
openalex   +2 more sources

Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification

International Journal of Cancer, EarlyView.
What's New? Asbestos exposure is a major risk factor for pleural mesothelioma (PM). Most asbestos‐exposed individuals do not develop PM, suggesting that it arises from a complex interplay between environmental and genetic factors. This study examined the utility of polygenic risk scores (PRS) and methylation risk scores (MRS) in incorporating genetic ...
Khadija Sana Hafeez, Carla Debernardi, Alessandra Allione, Elton Jalis Herman, Simonetta Guarrera, Daniela Ferrante, Anna Aspesi, Marika Sculco, Marta La Vecchia, Carlotta Sacerdote, Federica Grosso, Christina M. Lill, Giovanna Masala, Marcela Guevara, Matthias B. Schulze, Salvatore Panico, Yaszan Asgari, Seehyun Park, Giovanna Tagliabue, Anne Tjønneland, Antonio Agudo, Elisabete Weiderpass, Corrado Magnani, Irma Dianzani, Paolo Vineis, Elisabetta Casalone, Giuseppe Matullo   +26 more
wiley   +1 more source

Unadjusted and genome-wide <i>p</i>-values for the four GWA analyses performed.

, 2016
Velie Brandon D., Merina Shrestha, Franҫois Liesbeth, Anouk Schurink, Tesfayonas Yohannes G., Anneleen Stinckens, B Sarah, Ducro Bart J., Mikko Sofia, Thomas J. Ruth, E. Swinburne June, Sundqvist Marie, S. Eriksson, Nadine Buys, Gabriella Lindgren   +14 more
openalex   +2 more sources

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, EarlyView.
What's New? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

Pharmacogenomics And Hypertension: Current Insights

Pharmacogenomics and Personalized Medicine, 2019
Gustavo H Oliveira-Paula,1,2 Sherliane C Pereira,2 Jose E Tanus-Santos,2 Riccardo Lacchini3 1Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, NY, USA ...
Oliveira-Paula GH, Pereira SC, Tanus-Santos JE, Lacchini R   +3 more
doaj  

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Additional file 2: of A post-GWAS confirming effects of PRKG1 gene on milk fatty acids in a Chinese Holstein dairy population

, 2019
Lijun Shi, Xiaoqing Lv, Lin Liu, Yuze Yang, Zhu Ma, Bo Han, Dongxiao Sun   +6 more
openalex   +1 more source