Results 151 to 160 of about 244,292 (300)

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun, Di Ma, Wuqiong Zhang, Shuai Hou, Zhiqing Chen, Xuewei Li, Hongmei Meng, Daguang Zhang   +7 more
wiley   +1 more source

An Effector Index to Predict Target Genes at GWAS Loci [PDF]

, 2021
Vincenzo Forgetta, Lai Jiang, Nicholas A. Vulpescu, Meganq Hogan, Siyuan Chen, John Morris, Stepan Grinek, Christian Benner, Dongkeun Jang, Quy Hoang, Noël P. Burtt, Jason Flannick, Mark I. McCarthy, Eric B. Fauman, Celia M.T. Greenwood, Matthew T. Maurano, Brent Richards   +16 more
openalex   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, EarlyView.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source

Estimation of the genetic Gaussian network using GWAS summary data [PDF]

Yihe Yang, Noah Lorincz‐Comi, Xiaofeng Zhu   +2 more
openalex   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

GWAS reveals new recessive loci associated with non-syndromic facial clefting

, 2012
Maurício Camargo, Dora Rivera, Lina M. Moreno, Andrew C. Lidral, Ursula L. Harper, MaryPat Jones, Benjamin D. Solomon, Erich Roessler, Jorge I. Vélez, Ariel F. Martinez, Settara C. Chandrasekharappa, Mauricio Arcos‐Burgos   +11 more
openalex   +2 more sources

Multi-phase, multi-ethnic GWAS uncovers putative loci in predisposition to human sprint performance, health and disease [PDF]

, 2023
Guan Wang, Noriyuki Fuku, Eri Miyamoto‐Mikami, Masashi Tanaka, Motohiko Miyachi, Haruka Murakami, Yu‐Ching Cheng, Braxton D. Mitchell, Errol Morrison, Krista G. Austin, Ildus I. Ahmetov, Edward V. Generozov, М. Л. Филипенко, Andrei A. Gilep, Valentina Ginevičienė, Colin N. Moran, Tomas Venckūnas, Paweł Cięszczyk, Wim Derave, Ioannis Papadimitriou, Fleur C. Garton, Kathryn N. North, Sandosh Padmanabhan, Yannis Pitsiladis   +23 more
openalex   +1 more source

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

Association of Lactate with Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study

Vascular Health and Risk Management
Xindi Chang,* Wang Zheng,* Yingli Zhao, Wangkang Niku, Bing Deng, Ping Liu, Yiru Wang Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China*These authors ...
Chang X, Zheng W, Zhao Y, Niku W, Deng B, Liu P, Wang Y   +6 more
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