Results 181 to 190 of about 283,327 (339)

Investigation of target sequencing of SARS-CoV-2 and immunogenic GWAS profiling in host cells of COVID-19 in Vietnam [PDF]

, 2022
Tham H. Hoang, Giang M. Vu, Mai Tran, Trang T. H. Tran, Quang D. Le, Khanh V. Tran, Tue T. Nguyen, Lan Thi Nguyen, Thinh Huy Tran, Van Thanh Ta, Nam S. Vo   +10 more
openalex   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

, 2023
Florian Wünnemann, Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P. Kleinstiver, Guillaume Lettre   +6 more
openalex   +2 more sources

Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study

Epilepsia Open, EarlyView.
Abstract Objective Understanding the role of plasma proteins in the pathophysiology of epilepsy is crucial for uncovering novel biological mechanisms and therapeutic targets. Mendelian randomization (MR) provides a valuable tool for dissecting potentially causal associations between circulating proteins and disease risk.
Jingfeng Fu, Wei Wu, Shangren Shen
wiley   +1 more source

Global Stress Responses Identify the Functionally Divergent Regulators Required for Candida auris Commensalism and Pathogenicity

Exploration, EarlyView.
Candida auris is an emerging multidrug‐resistant fungal pathogen that poses a serious global health threat. In our study, we comprehensively delineate both the pan‐genomic and transcriptomic features of C. auris. Intriguingly, our findings reveal an unexpected alkaline pH‐dependent regulation required for C. auris virulence and commensalism mediated by
Chaoyue Xu, Wanxing Xu, Yushun Yuan, Xiaoqing Chen, Ouyang Mo, Zhe Yin, Xinhua Huang, Yuanyuan Wang, Lingfei Hu, Wenwen Xue, Yun Zou, Luyao Zhang, Kunlin Li, Yueru Tian, Jihong Liu, Sichu Xiong, Lei Wu, Yanmei Dong, Guangsheng Chen, Yuping Zhang, Zili Zhou, Ming Guan, Xiaotian Huang, Zhiyi He, Lin Zhong, Lingbing Zeng, Pei Hao, Xiaoqi Zheng, Changbin Chen, Ning‐Ning Liu, Dongsheng Zhou   +30 more
wiley   +1 more source

Response to: ‘Correspondence on ‘Variants in urate transporters, ADH1B, GCKR and MEPE genes associated with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank” by Takei et al [PDF]

, 2021
Gabriela Sandoval‐Plata, Kevin Morgan, Abhishek Abhishek   +2 more
openalex   +1 more source

Serum Retinol Levels and Risk of Asthma: Evidence From the NHANES and Mendelian Randomization

Food Frontiers, EarlyView.
The results of cross‐sectional studies and MR analysis support an association between serum retinol and the prevalence of asthma in adults. Higher serum retinol levels may serve as a protective factor against asthma. ABSTRACT Given the ongoing controversy regarding the relationship between serum retinol levels and asthma, this study aims to clarify ...
Xingyang Chen, Meichen Li, Boyang Qu, Yanrong Ao, Hong Gu, Yuan Tian, Yuan Song, Weiwei Cui   +7 more
wiley   +1 more source

Leveraging models of cell regulation and GWAS data in integrative network-based association studies [PDF]

, 2012
Andrea Califano, Atul J. Butte, Stephen Friend, Trey Ideker, Eric E. Schadt   +4 more
openalex   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, EarlyView.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source

Genetic dissection of protein and starch during wheat grain development using QTL mapping and GWAS

, 2023
Yingxin Guo, Guanying Wang, Xin Guo, Songqi Chi, Hui Yu, Kaituo Jin, Heting Huang, Dehua Wang, Chongning Wu, Jichun Tian, Jiansheng Chen, Yinguang Bao, Weidong Zhang, Zhiying Deng   +13 more
openalex   +1 more source