Results 11 to 20 of about 283,327 (339)
Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens [PDF]
Science, 2023 Most variants associated with complex traits and diseases identified by genome-wide association studies (GWAS) map to noncoding regions of the genome with unknown effects.
John Morris +15 more
openalex +2 more sources
The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource
Nucleic Acids Res., 2022 The NHGRI-EBI GWAS Catalog (www.ebi.ac.uk/gwas) is a FAIR knowledgebase providing detailed, structured, standardised and interoperable genome-wide association study (GWAS) data to >200 000 users per year from academic research, healthcare and industry ...
E. Sollis +29 more
semanticscholar +1 more source
Diabetes Care, 2023 OBJECTIVE Depression is a common comorbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them. RESEARCH DESIGN AND METHODS We applied two-sample, bidirectional Mendelian randomization (MR) to assess causality ...
Jared G. Maina +10 more
semanticscholar +1 more source
Investigating the genetic architecture of non-cognitive skills using GWAS-by-subtraction
Nature Genetics, 2021 Little is known about the genetic architecture of traits affecting educational attainment other than cognitive ability. We used genomic structural equation modeling and prior genome-wide association studies (GWASs) of educational attainment (n = 1,131 ...
F. Dostoyevsky +27 more
semanticscholar +1 more source
Molecular genetic aspects of sudden cardiac death: a literature review
Бюллетень сибирской медицины, 2018 Sudden cardiac death (SCD) continues to be a relevant and significant problem in modern medicine. Modern trends in medicine are associated with the widespread introduction of personalized, preventive strategies aimed at correcting risk factors for ...
A. A. Ivanova, V. N. Maksimov
doaj +1 more source
Nucleic Acids Res., 2018 The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies.
A. Buniello +23 more
semanticscholar +1 more source
Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery
bioRxiv, 2022 Most signals in genome-wide association studies (GWAS) of complex traits point to noncoding genetic variants with putative gene regulatory effects. However, currently identified expression quantitative trait loci (eQTLs) explain only a small fraction of ...
H. Mostafavi +3 more
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2020 Bayesian regression methods that incorporate different mixture priors for marker effects are used in multi-trait genomic prediction. These methods can also be extended to genome-wide association studies (GWAS).
Zigui Wang +3 more
doaj +1 more source
Nature Communications, 2021 Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
Yeda Wu +5 more
semanticscholar +1 more source
Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Genome Biology, 2021 The resources generated by the GTEx consortium offer unprecedented opportunities to advance our understanding of the biology of human diseases. Here, we present an in-depth examination of the phenotypic consequences of transcriptome regulation and a ...
A. Barbeira +27 more
semanticscholar +1 more source