Results 11 to 20 of about 274,572 (340)
Clinical Journal of the American Society of Nephrology, 2022 Background and objectives Glomerular hematuria has varied causes but can have a genetic basis, including Alport syndrome and IgA nephropathy. Design, setting, participants, & measurements We used summary statistics to identify genetic variants associated with hematuria in White ...
Sarah A. Gagliano Taliun +6 more
openalex +4 more sources
, 2021 GWAS Matrix: Contain all the GWAS results with the input phenotype (coordinates of pseudo-SNPs) and all the GWAS SNPs p-value detected.
benjamin jaegle
openalex +3 more sources
BTOB: Extending the Biased GWAS to Bivariate GWAS [PDF]
Frontiers in Genetics, 2021 In recent years, a number of literatures published large-scale genome-wide association studies (GWASs) for human diseases or traits while adjusting for other heritable covariate. However, it is known that these GWASs are biased, which may lead to biased genetic estimates or even false positives.
Zhu, Junxian +4 more
openaire +3 more sources
Five years of GWAS discovery. [PDF]
The American Journal of Human Genetics, 2012 The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aimed at detecting variants at genomic loci that are associated with complex traits in the population and, in particular, at detecting associations between common single-nucleotide ...
P. Visscher +3 more
semanticscholar +6 more sources
Reducing GWAS Complexity [PDF]
Cell Cycle, 2016 Genome-wide association studies (GWAS) have revealed numerous genomic 'hits' associated with complex phenotypes. In most cases these hits, along with surrogate genetic variation as measure by numerous single nucleotide polymorphisms (SNPs) that are in linkage disequilibrium, are not in coding genes making assignment of functionality or causality ...
Dennis J, Hazelett +8 more
openaire +2 more sources
HAPPI GWAS: Holistic Analysis with Pre and Post Integration GWAS [PDF]
Bioinformatics, 2020 AbstractMotivationAdvanced publicly available sequencing data from large populations have enabled in-formative genome-wide association studies (GWAS) that associate SNPs with phenotypic traits of interest. Many publicly available tools able to perform GWAS have been developed in response to increased demand.
Marianne L Slaten +4 more
openaire +2 more sources
Investigating the genetic architecture of non-cognitive skills using GWAS-by-subtraction
Nature Genetics, 2021 Little is known about the genetic architecture of traits affecting educational attainment other than cognitive ability. We used genomic structural equation modeling and prior genome-wide association studies (GWASs) of educational attainment (n = 1,131 ...
F. Dostoyevsky +27 more
semanticscholar +1 more source
Nucleic Acids Res., 2018 The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies.
A. Buniello +23 more
semanticscholar +1 more source
Nature Communications, 2021 Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
Yeda Wu +5 more
semanticscholar +1 more source
The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Nucleic Acids Res., 2013 The National Human Genome Research Institute (NHGRI) Catalog of Published Genome-Wide Association Studies (GWAS) Catalog provides a publicly available manually curated collection of published GWAS assaying at least 100 000 single-nucleotide polymorphisms
Danielle Welter +10 more
semanticscholar +1 more source