Results 11 to 20 of about 256,390 (380)

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

Nature Genetics, 2021
Genome-wide association studies (GWASs) have identified many variants associated with complex traits, but identifying the causal gene(s) is a major challenge.
Edward Mountjoy, Ellen M. Schmidt, M. Carmona, Gareth Peat, Alfredo Miranda, Luca Fumis, J. Hayhurst, A. Buniello, J. Schwartzentruber, M. Karim, Daniel Wright, Andrew Hercules, Eliseo Papa, E. Fauman, J. Barrett, J. Todd, D. Ochoa, I. Dunham, M. Ghoussaini   +18 more
semanticscholar   +1 more source

Unifying candidate gene and GWAS Approaches in Asthma. [PDF]

, 2010
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS ...
Berg, Andrea von, Bufe, Albrecht, Depner, Martin, Frischer, Thomas, Genuneit, Jon, Gut, Ivo G., Heinzmann, Andrea, Illig, Thomas, Kabesch, Michael, Klopp, Norman, Kumar, Ashish, Lathrop, Mark, Laub, Otto, Liang, Liming, Michel, Sven, Mutius, Erika von, Rietschel, Ernst, Ruether, Andreas, Schedel, Michaela, Schreiber, Stefan, Simma, Burkhard, Vogelberg, Christian   +21 more
core   +6 more sources

Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidence

Canadian Journal of Pain, 2021
Background Chronic postsurgical pain (CPSP) in children remains an important problem with no effective preventive or therapeutic strategies. Recently, genomic underpinnings explaining additional interindividual risk beyond psychological factors have been
Adam. J. Dourson, Adam. Willits, Namrata.G.R. Raut, Leena Kader, Erin Young, Michael.P. Jankowski, Vidya Chidambaran   +6 more
doaj   +1 more source

Resequencing of 558 Chinese mungbean landraces identifies genetic loci associated with key agronomic traits

Frontiers in Plant Science, 2022
Mungbean is a warm-season annual food legume and plays important role in supplying food and nutritional security in many tropical countries. However, the genetic basis of its agronomic traits remains poorly understood.
Xuesong Han, Li Li, Hongwei Chen, Liangjun Liu, Longqin Sun, Xingmin Wang, Yantao Xiang, Zhenghuang Wan, Changyan Liu   +8 more
doaj   +1 more source

Functional analysis and signaling pathway enrichment analysis of genes associated with Alzheimer’s disease and Parkinson’s disease

Бюллетень сибирской медицины, 2020
We identified significant functions of susceptibility-genes and performed an analysis of pathway enrichment for Alzheimer’s disease, Parkinson’s disease and for both of them.
N. Yu. Chasovskikh, A. Yu. Grechishnikova, D. V. Smirnov   +2 more
doaj   +1 more source

GWAS is going to the dogs [PDF]

Genome Biology, 2014
AbstractGenome-wide association studies in canine models may help locate genomic susceptibility regions that are relevant to human disease.See related Research: http://genomebiology.com/2014/15/3 ...
Mitchell J. Machiela, Stephen J. Chanock
openaire   +3 more sources

Features of functional annotation of rheumatoid arthritis susceptibility genes by Cytoscape

Бюллетень сибирской медицины, 2020
Aim. To evaluate the functional annotation of genes associated with rheumatoid arthritis with different parameters of the ClueGO Cytoscape tool.Materials and methods.
N. Yu. Chasovskikh
doaj   +1 more source

Genome wide association study of growth and feed efficiency traits in rabbits

World Rabbit Science, 2023
Feed efficiency is a major production trait in animal genetic breeding schemes. To further investigate the genetic control of feed efficiency in rabbits, we performed a genome-wide association study (GWAS) for growth and feed efficiency on 679 rabbits ...
Hervé Garreau, Yann Labrune, Hervé Chapuis, Julien Ruesche, Juliette Riquet, Julie Demars, Florence Benitez, François Richard, Laurence Drouilhet, Olivier Zemb, Hélène Gilbert   +10 more
doaj   +1 more source

Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery

bioRxiv, 2022
Most signals in genome-wide association studies (GWAS) of complex traits point to noncoding genetic variants with putative gene regulatory effects. However, currently identified expression quantitative trait loci (eQTLs) explain only a small fraction of ...
H. Mostafavi, J. Spence, S. Naqvi, J. Pritchard   +3 more
semanticscholar   +1 more source

Genetic Basis Dissection for Eating and Cooking Qualities of Japonica Rice in Northeast China

Agronomy, 2020
The japonica rice in Northeast China is famous because of its high quality. Eating and cooking qualities (ECQs) are the most important factors that determine cooked rice quality.
Yaolong Yang, Xin Xu, Mengchen Zhang, Qun Xu, Yue Feng, Xiaoping Yuan, Hanyong Yu, Yiping Wang, Xinghua Wei   +8 more
doaj   +1 more source