Results 31 to 40 of about 256,390 (380)

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

Nucleic Acids Res., 2018
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies.
A. Buniello, J. MacArthur, M. Cerezo, Laura W. Harris, J. Hayhurst, Cinzia Malangone, A. McMahon, Joannella Morales, Edward Mountjoy, E. Sollis, D. Suveges, Olga Vrousgou, P. Whetzel, R. Amode, Jose A. Guillen, H. Riat, S. Trevanion, Peggy Hall, Heather Junkins, P. Flicek, Tony Burdett, L. Hindorff, Fiona Cunningham, H. Parkinson   +23 more
semanticscholar   +1 more source

Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications

Bone Research, 2021
Osteoporosis is a common skeletal disease, affecting ~200 million people around the world. As a complex disease, osteoporosis is influenced by many factors, including diet (e.g. calcium and protein intake), physical activity, endocrine status, coexisting
Xiaowei Zhu, Weiyang Bai, Houfeng Zheng
semanticscholar   +1 more source

Don't give up on GWAS [PDF]

Molecular Psychiatry, 2011
Buitelaar J, Bulik CM, Cichon S, Collier D, Corvin A, Craddock N, DeLisi LE, Ebstein R, Edenberg HJ, Estivill X, Faraone SV, Farmer AE, Fernandez-Aranda F, Flint J, Foroud T, Franke B, Gelernter J, Gill M, Grabe HJ, Hamilton SP, Hickie IB, Hoogendijk W, Jablensky A, Kalaydjieva L, Kaprio J, Kas M, Keller M, Kelsoe J, Kendler KS, Kennedy M, Kent L ...
Sullivan, P., Andreassen, Ole A, Anney, Richard J L, Asherson, Philip, Ashley-Koch, Allison, Blackwood, Douglas, Boomsma, Dorret I, Breen, Gerome, Buitelaar, Jan, Bulik, Cynthia M, Cichon, Sven, Collier, David, Corvin, Aiden, Craddock, Nicholas, DeLisi, Lynn E, Ebstein, Richard, Edenberg, Howard J, Estivill, Xavier, Faraone, Stephen V, Farmer, Anne E, Fernandez-Aranda, Fernando, Flint, Jonathan, Foroud, Tatiana, Franke, Barbara, Gelernter, Joel, Gill, Michael, Grabe, Hans J, Hamilton, Steven P, Hickie, Ian B, Hoogendijk, Witte, Jablensky, Assen, Kalaydjieva, Luba, Kaprio, Jaakko, Kas, Martien, Keller, Matthew, Kelsoe, John, Kendler, Kenneth S, Kennedy, Martin, Kent, Lindsey, Klump, Kelly, Knowles, James A, Levinson, Douglas F, Lewis, Cathryn M, Lichtenstein, Paul, Lucae, Susanne, Martin, Nicholas G, McCarroll, Steve, McGough, James, McGrath, John J, McGuffin, Peter, Mitchell, Philip, Mowry, Bryan, Muglia, Pierandrea, Müller-Myhsok, Bertram, Neale, Benjamin, Nöthen, Markus, Nurnberger, John I, Oades, Robert D., O'Donovan, Michael, Ophoff, Roel, Owen, Michael, Pato, Carlos N, Pato, Michele T, Penninx, Brenda W, Perlis, Roy H, Porjesz, Bernice, Posthuma, Danielle, Potash, James B, Preisig, Martin, Reichborn-Kjennerud, Ted, Rice, John P, Rietschel, Marcella, Riley, Brien, Ripke, Stephan, Rothenberger, Aribert, Rujescu, Dan, Santangelo, Susan L, Schachar, Russell, Schellenberg, Gerard D, Scherer, Stephen W, Schofield, Peter, Schulze, Thomas G, Sklar, Pamela, Smoller, Jordan W, Stefansson, Hreinn, Stefansson, Kari, Todorov, Alexandre, Tozzi, Federica, Tzeng, Jung-Ying, van den Oord, Edwin J. C. G., Vorstman, Jacob A S, Wang, Kai, Weissman, Myrna M, Werge, Thomas, Wray, Naomi R, Zeggini, Eleftheria   +95 more
openaire   +6 more sources

Enabling Privacy-Preserving GWAS in Heterogeneous Human Populations [PDF]

, 2016
The projected increase of genotyping in the clinic and the rise of large genomic databases has led to the possibility of using patient medical data to perform genomewide association studies (GWAS) on a larger scale and at a lower cost than ever before ...
Berger, Bonnie, Sahinalp, Cenk, Simmons, Sean   +2 more
core   +2 more sources

Single-Step Genome-Wide Association Study for Resistance to Piscirickettsia salmonis in Rainbow Trout (Oncorhynchus mykiss)

G3: Genes, Genomes, Genetics, 2019
One of the main pathogens affecting rainbow trout (Oncorhynchus mykiss) farming is the facultative intracellular bacteria Piscirickettsia salmonis. Current treatments, such as antibiotics and vaccines, have not had the expected effectiveness in field ...
Agustin Barria, Rodrigo Marín-Nahuelpi, Pablo Cáceres, María E. López, Liane N. Bassini, Jean P. Lhorente, José M. Yáñez   +6 more
doaj   +1 more source

Achieving GWAS with homomorphic encryption [PDF]

BMC Medical Genomics, 2020
Abstract Background One way of investigating how genes affect human traits would be with a genome-wide association study (GWAS). Genetic markers, known as single-nucleotide polymorphism (SNP), are used in GWAS. This raises privacy and security concerns as these genetic markers can be used to identify individuals uniquely.
Jun Jie Sim, Benjamin Hong Meng Tan, Shibin Chen, Khin Mi Mi Aung, Fook Mun Chan   +4 more
openaire   +5 more sources

From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases

Frontiers in Genetics, 2020
Genome-wide association studies (GWAS) have successfully mapped thousands of loci associated with complex traits. These associations could reveal the molecular mechanisms altered in common complex diseases and result in the identification of novel drug ...
E. Cano-Gamez, G. Trynka
semanticscholar   +1 more source

Revisiting the genome-wide significance threshold for common variant GWAS

G3, 2021
Over the last decade, GWAS meta-analyses have used a strict P-value threshold of 5 × 10−8 to classify associations as significant. Here, we use our current understanding of frequently studied traits including lipid levels, height, and BMI to revisit this
Zhongsheng Chen, M. Boehnke, Xiaoquan Wen, B. Mukherjee   +3 more
semanticscholar   +1 more source

Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

Human Vaccines & Immunotherapeutics, 2023
In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors.
Jennifer Connors, Gina Cusimano, Nathan Mege, Kyra Woloszczuk, Emily Konopka, Matthew Bell, David Joyner, Jennifer Marcy, Virginie Tardif, Michele A. Kutzler, Roshell Muir, Elias K. Haddad   +11 more
doaj   +1 more source

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

Nucleic Acids Res., 2013
The National Human Genome Research Institute (NHGRI) Catalog of Published Genome-Wide Association Studies (GWAS) Catalog provides a publicly available manually curated collection of published GWAS assaying at least 100 000 single-nucleotide polymorphisms
Danielle Welter, J. MacArthur, Joannella Morales, Tony Burdett, Peggy Hall, Heather Junkins, Alan Klemm, P. Flicek, T. Manolio, L. Hindorff, H. Parkinson   +10 more
semanticscholar   +1 more source