Results 31 to 40 of about 274,572 (340)
Frontiers in Genetics, 2021 Since their inception, genome-wide association studies (GWAS) have identified more than a hundred thousand single nucleotide polymorphism (SNP) loci that are associated with various complex human diseases or traits.
Binglan Li, M. Ritchie
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Blood, 2015 In this issue of Blood , [Sato-Otsubo et al][1] perform a genome-wide association study (GWAS) to identify minor histocompatibility antigens associated with clinically relevant graft-versus-host disease (GVHD).[1][2] ![Figure][3] Schematic representation of different factors influencing ...
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Genetic regulation of mouse liver metabolite levels. [PDF]
, 2014 We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J +11 more
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Nature Genetics, 2010 Analyses of genome-wide association studies (GWAS) show that common SNPs can account for the majority of the heritability of complex traits, but that there are likely to be limits to the usefulness of the current strategy of accumulating common variants of small effect for risk prediction.
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GWAS quality score for evaluating associated regions in GWAS analyses
Bioinformatics, 2023 Abstract Motivation The number of significantly associated regions reported in genome-wide association studies (GWAS) for polygenic traits typically increases with sample size. A traditional tool for quality control and identification of significant regions has been a visual inspection of how ...
Swapnil Awasthi +5 more
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Genome-Wide Association Study and Subsequent Exclusion of ATCAY as a Candidate Gene Involved in Equine Neuroaxonal Dystrophy Using Two Animal Models. [PDF]
, 2020 Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is an inherited neurodegenerative disorder of unknown etiology. Clinical signs of neurological deficits develop within the first year of life in vitamin E (vitE) deficient ...
Dahlgren, Anna R +6 more
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TIGA: target illumination GWAS analytics [PDF]
Bioinformatics, 2020 Abstract Motivation Genome-wide association studies can reveal important genotype–phenotype associations; however, data quality and interpretability issues must be addressed. For drug discovery scientists seeking to prioritize targets based on the available evidence, these issues go beyond the ...
Jeremy J Yang +8 more
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qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots
bioRxiv, 2014 Summary Genome-wide association studies (GWAS) have identified thousands of human trait-associated single nucleotide polymorphisms. Here, I describe a freely available R package for visualizing GWAS results using Q-Q and manhattan plots.
Stephen D. Turner
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Achieving GWAS with homomorphic encryption [PDF]
BMC Medical Genomics, 2020 Abstract Background One way of investigating how genes affect human traits would be with a genome-wide association study (GWAS). Genetic markers, known as single-nucleotide polymorphism (SNP), are used in GWAS. This raises privacy and security concerns as these genetic markers can be used to identify individuals uniquely.
Jun Jie Sim +4 more
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The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity
Nucleic Acids ResearchThe NHGRI-EBI GWAS Catalog serves as a vital resource for the genetic research community, providing access to the most comprehensive database of human GWAS results.
Maria Cerezo +22 more
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