Results 41 to 50 of about 247,905 (333)
Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. [PDF]
, 2019 The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease.
Aguiar +76 more
core +2 more sources
Nature Genetics, 2009 Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
openaire +2 more sources
Genome-Wide Multiple Sclerosis Association Data and Coagulation [PDF]
, 2019 The emerging concept of a crosstalk between hemostasis, inflammation, and immune system prompt recent works on coagulation cascade in multiple sclerosis (MS).
Arianna Fornasiero +10 more
core +2 more sources
GenEpi: gene-based epistasis discovery using machine learning. [PDF]
, 2020 BackgroundGenome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Alzheimer’s Disease Neuroimaging Initiative +9 more
core
Tissue-specific network-based genome wide study of amygdala imaging phenotypes to identify functional interaction modules [PDF]
, 2017 Motivation: Network-based genome-wide association studies (GWAS) aim to identify functional modules from biological networks that are enriched by top GWAS findings.
Alzheimer’s Disease Neuroimaging Initiative +10 more
core +1 more source
Molecular genetic aspects of sudden cardiac death: a literature review
Бюллетень сибирской медицины, 2018 Sudden cardiac death (SCD) continues to be a relevant and significant problem in modern medicine. Modern trends in medicine are associated with the widespread introduction of personalized, preventive strategies aimed at correcting risk factors for ...
A. A. Ivanova, V. N. Maksimov
doaj +1 more source
Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies [PDF]
, 2019 Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted
Gilles de la Tourette GWAS Replication Initiative +4 more
core +1 more source
Thorax, 2011 We read with interest the recent article ‘Genome-wide association studies in lung disease’ by Artigas et al. 1 While we agree that a greater understanding of the biological pathways underlying disease development and progression (susceptibility) will be a major outcome from these genetic epidemiological studies, we suggest other benefits may also stem ...
Robert P, Young, Raewyn J, Hopkins
openaire +2 more sources
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students [PDF]
, 2017 Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms ...
Adkins, Amy +16 more
core +2 more sources