Results 41 to 50 of about 274,572 (340)

Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer’s disease GWAS and self-report proxy phenotype GWAX

Alzheimer's Research & Therapy, 2022
Background Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer’s disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS
Haijie Liu, Yang Hu, Yan Zhang, Haihua Zhang, Shangde Gao, Longcai Wang, Tao Wang, Zhifa Han, Baocheng Sun, Guiyou Liu   +9 more
semanticscholar   +1 more source

GWAS and drug targets [PDF]

BMC Genomics, 2014
Genome wide association studies (GWAS) have revealed a large number of links between genome variation and complex disease. Among other benefits, it is expected that these insights will lead to new therapeutic strategies, particularly the identification of new drug targets.
Cao, Chen, Moult, John
openaire   +3 more sources

Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]

, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas, Jhamb, Deepali, Rajpal, Deepak K, Shu, Le, Yang, Xia, Zhao, Yuqi   +5 more
core   +3 more sources

Genome-Wide Association Study for Maize Leaf Cuticular Conductance Identifies Candidate Genes Involved in the Regulation of Cuticle Development. [PDF]

, 2020
The cuticle, a hydrophobic layer of cutin and waxes synthesized by plant epidermal cells, is the major barrier to water loss when stomata are closed at night and under water-limited conditions.
Baseggio, Matheus, Chamness, James, Gore, Michael A, Kaczmar, Nicholas, Lin, Meng, Matschi, Susanne, Miller, Michael, Molina, Isabel, Qiao, Pengfei, Scanlon, Michael J, Smith, Laurie G, Stewart, Ethan L, Vasquez, Miguel   +12 more
core   +2 more sources

Genetics of coronary artery disease in the post‐GWAS era

Journal of Internal Medicine, 2021
During the past decade, genome‐wide association studies (GWAS) have transformed our understanding of many heritable traits. Three recent large‐scale GWAS meta‐analyses now further markedly expand the knowledge on coronary artery disease (CAD) genetics in
Zhifen Chen, H. Schunkert
semanticscholar   +1 more source

High marks for GWAS [PDF]

Nature Genetics, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
openaire   +2 more sources

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Nature Communications, 2016
Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its ...
A. Barbeira, Scott P. Dickinson, Rodrigo Bonazzola, Jiamao Zheng, H. Wheeler, Jason M. Torres, E. Torstenson, Kaanan P. Shah, Tzintzuni I. Garcia, T. Edwards, E. Stahl, L. Huckins, François Kristin G. Beryl B. Ellen T. Gad Kane Robert E. Ka Aguet Ardlie Cummings Gelfand Getz Hadley Handsake, François Kristin G. Beryl B. Ellen T. Gad Kane Robert E. Ka Aguet Ardlie Cummings Gelfand Getz Hadley Handsake, F. Aguet, K. Ardlie, Beryl B. Cummings, Ellen T. Gelfand, G. Getz, Kane Hadley, R. Handsaker, Katherine H. Huang, Seva Kashin, K. Karczewski, M. Lek, Xiao Li, D. MacArthur, Jared L. Nedzel, D. T. Nguyen, M. Noble, A. Segrè, Casandra A. Trowbridge, T. Tukiainen, Nathan S. Brunilda Ruth Omer Alexis Gireesh K. Andrew Chr Abell Balliu Barshir Basha Battle Bogu Brown Brown, Nathan S. Abell, Brunilda Balliu, Ruth Barshir, Omer Basha, A. Battle, G. Bogu, A. Brown, Christopher D. Brown, Stephane E. Castel, Lin S. Chen, Colby Chiang, D. Conrad, Farhan N. Damani, Joe R. Davis, O. Delaneau, E. Dermitzakis, B. Engelhardt, E. Eskin, Pedro G. Ferreira, L. Frésard, E. Gamazon, D. Garrido-Martín, Ariel D. H. Gewirtz, Genna Gliner, Michael J. Gloudemans, R. Guigó, I. Hall, Buhm Han, Yuan He, F. Hormozdiari, C. Howald, Brian Jo, Eun Yong Kang, Yungil Kim, Sarah Kim-Hellmuth, T. Lappalainen, Gen Li, Xin Li, Boxiang Liu, S. Mangul, M. McCarthy, Ian C. McDowell, P. Mohammadi, Jean Monlong, S. Montgomery, Manuel Muñoz-Aguirre, Anne W. Ndungu, A. Nobel, Meritxell Oliva, H. Ongen, John Palowitch, N. Panousis, Panagiotis K. Papasaikas, YoSon Park, P. Parsana, Anthony J. Payne, Christine B. Peterson, J. Quan, F. Reverter, C. Sabatti, A. Saha, M. Sammeth, Alexandra J. Scott, A. Shabalin, Reza Sodaei, M. Stephens, B. Stranger, B. Strober, J. Sul, Emily K. Tsang, Sarah Urbut, M. van de Bunt, Gao Wang, Xiaoquan Wen, Fred A. Wright, H. Xi, Esti Yeger-Lotem, Zachary Zappala, Judith B. Zaugg, Yi-Hui Zhou, Joshua M. Daniel Joanne Lin S. Melina Kathryn Morgan Jenn Akey Bates Chan Chen Claussnitzer Demanelis Diegel, J. Akey, Daniel Bates, Joanne Chan, M. Claussnitzer, Kathryn Demanelis, Morgan Diegel, J. Doherty, A. Feinberg, Maria S. Fernando, J. Halow, Kasper D. Hansen, E. Haugen, P. Hickey, Lei Hou, F. Jasmine, Ruiqi Jian, Lihua Jiang, Audra K. Johnson, R. Kaul, Manolis Kellis, M. Kibriya, Kristen Lee, J. B. Li, Qin Li, Xiao Li, Jessica Lin, Shin Lin, Sandra Linder, C. Linke, Yaping Liu, Matthew T. Maurano, B. Molinie, Jemma Nelson, Fidencio J. Neri, Yongjin P. Park, B. Pierce, Nicola J. Rinaldi, L. Rizzardi, R. Sandstrom, Andrew Skol, Kevin S. Smith, Michael P. Snyder, J. Stamatoyannopoulos, Hua Tang, Li Wang, M. Wang, Nicholas Van Wittenberghe, Fan Wu, Rui Zhang, C. Nierras, Philip A. Latarsha J. Ping Helen M. Abhi Jimmie B. Branton Carithers Guan Moore Rao Vaught, P. Branton, Latarsha J. Carithers, P. Guan, Helen M. Moore, Abhi Rao, J. Vaught, Sarah E. Nicole C. Casey Jeffery P. Simona Gould Lockart Martin Struewing Volpi, Sarah E. Gould, Nicole C. Lockart, Casey Martin, J. Struewing, S. Volpi, Anjene M. Susan E. Addington Koester, A. Addington, S. Koester, A. Little, Lori E. Richard Marcus Christopher Mark Gene William F. Brigham Hasz Hunter Johns Johnson Kopen Leinweber , L. Brigham, R. Hasz, Marcus Hunter, Christopher Johns, Mark Johnson, G. Kopen, W. F. Leinweber, J. Lonsdale, Alisa McDonald, Bernadette Mestichelli, K. Myer, Brian Roe, Mike Salvatore, Saboor Shad, Jeffrey A. Thomas, Gary Walters, Michael Washington, Joseph Wheeler, Jason Barbara A. Bryan M. Ellen Rachna Mark Michael T. Bridge Foster Gillard Karasik Kumar Miklos Moser, J. Bridge, B. Foster, Bryan M. Gillard, E. Karasik, Rachna Kumar, Mark Miklos, M. T. Moser, Scott D. Robert G. Daniel C. Dana R. Jewell Montroy Rohrer Valley, S. Jewell, Robert G. Montroy, D. Rohrer, Dana R. Valley, David A. Deborah C. Davis Mash, D. Davis, Deborah C. Mash, Anita H. Anna M. David E. Nancy V. Jeffrey A. Negin Karn Undale Smith Tabor Roche McLean Vatanian Robinson , Anita H. Undale, Anna M. Smith, D. Tabor, Nancy V. Roche, J. McLean, Negin Vatanian, Karna L. Robinson, L. Sobin, M. Barcus, Kimberly M. Valentino, L. Qi, Steven Hunter, P. Hariharan, Shilpi Singh, K. S. Um, Takunda Matose, M. Tomaszewski, Laura K. Maghboeba Laura A. Heather M. Barker Mosavel Siminoff Traino, Laura K. Barker, M. Mosavel, L. Siminoff, H. Traino, Paul Thomas Magali Dan Kieron Stephen J. Daniel R. Flicek Juettemann Ruffier Sheppard Taylor Trevanio, Paul Flicek, Thomas Juettemann, Magali Ruffier, Daniel Sheppard, K. Taylor, S. Trevanion, D. Zerbino, Brian Mary Maximilian W. James Christopher M. Benedict K Craft Goldman Haeussler Kent Lee Paten Rosenbloom , Brian Craft, M. Goldman, M. Haeussler, W. Kent, Christopher M. Lee, B. Paten, K. Rosenbloom, John Vivian, Jingchun Zhu, Dan L. Nicolae, N. Cox, H. Im   +260 more
semanticscholar   +1 more source

Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. [PDF]

, 2019
The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease.
Aguiar, Assis, Auton, Bijvelds, Blackwell, Bonder, D'Antonio, D'Antonio-Chronowska, DeBoever, Dechecchi, DeGiorgio, Dendrou, Diwakar, Dobin, Eguchi, Ernst, Fehrmann, Freudenberg, Gambino, Gensterblum-Miller, Giambartolomei, González-Galarza, Gough, Graffelman, Guo, Hardy, Harrow, Herrmann, Holoshitz, Huang, Jakubosky, Jakubosky, Jensen, Jia, Kilpinen, Kilpinen, Klein, Kontakioti, Kundaje, Laki, Lam, Lee, Leung, Li, Li, Li, Li, Li, Lyczak, Mahdi, Mall, Matzaraki, Mayba, McNicholas, Miretti, Morison, Munder, Nariai, Norman, Oldstone, Panopoulos, Panousis, Pier, Robinson, Sondo, Stegle, Stoltz, Streeter, Tan, Tomati, Trowsdale, Van der Auwera, Vicente, Wilke, Yin, Zhang, Zheng   +76 more
core   +2 more sources

Within-sibship GWAS improve estimates of direct genetic effects

bioRxiv, 2021
Estimates from genome-wide association studies (GWAS) represent a combination of the effect of inherited genetic variation (direct effects), demography (population stratification, assortative mating) and genetic nurture from relatives (indirect genetic ...
L. Howe, M. Nivard, T. Morris, A. Hansen, H. Rasheed, Yoonsu Cho, G. Chittoor, P. Lind, T. Palviainen, M. D. van der Zee, R. Cheesman, M. Mangino, Yunzhang Wang, Shuai Li, L. Klarić, S. Ratliff, L. Bielak, Marianne Nygaard, C. Reynolds, Jared V. Balbona, Christopher R. Bauer, D. Boomsma, A. Baras, A. Campbell, H. Campbell, Zhengming Chen, P. Christofidou, C. Dahm, D. Dokuru, L. Evans, E. D. de Geus, S. Giddaluru, S. Gordon, K. Harden, A. Havdahl, W. Hill, S. Kerr, Yongkang Kim, H. Kweon, A. Latvala, Liming Li, Kuang Lin, P. Martikainen, P. Magnusson, M. Mills, D. Lawlor, J. Overton, N. Pedersen, D. Porteous, Jeffrey Reid, K. Silventoinen, M. Southey, T. Mallard, E. Tucker-Drob, M. Wright, J. Hewitt, M. Keller, M. Stallings, K. Christensen, S. Kardia, P. Peyser, Jennifer A. Smith, James F. Wilson, J. Hopper, S. Hägg, T. Spector, J. Pingault, R. Plomin, M. Bartels, N. Martin, A. Justice, I. Millwood, K. Hveem, Ø. Naess, C. Willer, B. Åsvold, P. Koellinger, J. Kaprio, S. Medland, R. Walters, D. Benjamin, P. Turley, David M. Evans, G. Smith, C. Hayward, B. Brumpton, G. Hemani, N. Davies   +87 more
semanticscholar   +1 more source

GWAS in lung disease [PDF]

Thorax, 2011
We read with interest the recent article ‘Genome-wide association studies in lung disease’ by Artigas et al. 1 While we agree that a greater understanding of the biological pathways underlying disease development and progression (susceptibility) will be a major outcome from these genetic epidemiological studies, we suggest other benefits may also stem ...
Robert P, Young, Raewyn J, Hopkins
openaire   +2 more sources