Results 41 to 50 of about 256,390 (380)
Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Genome Biology, 2021 The resources generated by the GTEx consortium offer unprecedented opportunities to advance our understanding of the biology of human diseases. Here, we present an in-depth examination of the phenotypic consequences of transcriptome regulation and a ...
A. Barbeira +27 more
semanticscholar +1 more source
Beyond the coding genome: non-coding mutations and cancer
Frontiers in Bioscience-Landmark, 2020 Latest advancements in genomics involving individuals from different races and geographical locations has led to the identification of thousands of common as well as rare genetic variants and copy number variations (CNVs). These studies have surprisingly
Kaivalya Walavalkar, Dimple Notani
doaj +1 more source
Cluster analysis of milk fat yield trait in dairy cows using meta-analysis of the genome-wide association studies [PDF]
پژوهش های علوم دامی, 2022 Introduction: Cow's milk is one of the most important animal products for any country and known as an important source for fat and protein originated from animals (Fenelon and Guinee, 1999, Martini et al., 2016).
S Bakhshalizadeh1, S Zerehdaran2* and A Javadmanesh3
doaj +1 more source
Alzheimer's Research & Therapy, 2022 Background Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer’s disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS
Haijie Liu +9 more
semanticscholar +1 more source
Animal Research and One Health, EarlyView., 2023 In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA‐seq. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation.
Yingxiao Su +9 more
wiley +1 more source
Molecular genetic aspects of sudden cardiac death: a literature review
Бюллетень сибирской медицины, 2018 Sudden cardiac death (SCD) continues to be a relevant and significant problem in modern medicine. Modern trends in medicine are associated with the widespread introduction of personalized, preventive strategies aimed at correcting risk factors for ...
A. A. Ivanova, V. N. Maksimov
doaj +1 more source
GWAS quality score for evaluating associated regions in GWAS analyses
Bioinformatics, 2023 Abstract Motivation The number of significantly associated regions reported in genome-wide association studies (GWAS) for polygenic traits typically increases with sample size. A traditional tool for quality control and identification of significant regions has been a visual inspection of how ...
Swapnil Awasthi +5 more
openaire +2 more sources
MAGMA: Generalized Gene-Set Analysis of GWAS Data
PLoS Comput. Biol., 2015 By aggregating data for complex traits in a biologically meaningful way, gene and gene-set analysis constitute a valuable addition to single-marker analysis. However, although various methods for gene and gene-set analysis currently exist, they generally
C. D. Leeuw +3 more
semanticscholar +1 more source
Frontiers in Genetics, 2021 Since their inception, genome-wide association studies (GWAS) have identified more than a hundred thousand single nucleotide polymorphism (SNP) loci that are associated with various complex human diseases or traits.
Binglan Li, M. Ritchie
semanticscholar +1 more source
Maximum difference analysis: a new empirical method for genome-wide association studies
Italian Journal of Animal Science, 2016 The availability of high-density single nucleotide polymorphism (SNPs) panels for humans and, recently, for several livestock species has given a great impulse to genome-wide association studies towards the identification of genes associated with complex
Massimo Cellesi +6 more
doaj +1 more source