Results 51 to 60 of about 274,572 (340)

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Genome-wide screening for DNA variants associated with reading and language traits [PDF]

, 2014
This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant ...
Bates, Timothy C, Brandler, William M, DeFries, John C, Evans, David M, Fisher, Simon E, Francks, Clyde, Gialluisi, Alessandro, Luciano, Michelle, Monaco, Anthony P, Newbury, Dianne F, Olson, Richard K, Paracchini, Silvia, Pennington, Bruce F, Scerri, Thomas S, Simpson, Nuala H, Smith, Shelley D, Stein, John F, Talcott, Joel B, The SLI Consortium, Wilcutt, Erik G   +19 more
core   +1 more source

Causal associations between risk factors and common diseases inferred from GWAS summary data

Nature Communications, 2017
Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of ...
Zhihong Zhu, Zhili Zheng, Futao Zhang, Yang Wu, M. Trzaskowski, Robert M. Maier, M. Robinson, J. Mcgrath, P. Visscher, N. Wray, Jian Yang   +10 more
semanticscholar   +1 more source

The variant call format provides efficient and robust storage of GWAS summary statistics

Genome Biology, 2020
GWAS summary statistics are fundamental for a variety of research applications yet no common storage format has been widely adopted. Existing tabular formats ambiguously or incompletely store information about genetic variants and associations, lack ...
M. Lyon, S. Andrews, B. Elsworth, Tom R. Gaunt, G. Hemani, Edoardo Marcora   +5 more
semanticscholar   +1 more source

Hope for GWAS: Relevant Risk Genes Uncovered from GWAS Statistical Noise [PDF]

International Journal of Molecular Sciences, 2014
Hundreds of genetic variants have been associated to common diseases through genome-wide association studies (GWAS), yet there are limits to current approaches in detecting true small effect risk variants against a background of false positive findings.
Correia, Catarina, Diekmann, Yoan, Vicente, Astrid M., Pereira-Leal, José B., Alexov, Emil   +4 more
openaire   +4 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays. [PDF]

, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Bandillo, Nonoy B, Buckler, Edward S, Diepenbrock, Christine H, Gore, Michael A, Kremling, Karl AG   +4 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies [PDF]

, 2019
Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted
Gilles de la Tourette GWAS Replication Initiative, Psychiatric Genomics Consortium Tourette Syndrome Working Group, Tourette Association of America International Consortium for Genetics, Tourette International Collaborative Genetics Study, Woods, Douglas W.   +4 more
core   +1 more source

Leveraging polygenic functional enrichment to improve GWAS power

bioRxiv, 2017
Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a method that leverages polygenic functional enrichment to incorporate coding, conserved ...
Gleb Kichaev, G. Bhatia, Po-Ru Loh, S. Gazal, Kathryn S. Burch, M. Freund, A. Schoech, B. Pasaniuc, A. Price   +8 more
semanticscholar   +1 more source