Results 51 to 60 of about 283,327 (339)
Population Genetics of Rare Variants and Complex Diseases [PDF]
, 2012 Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high throughput genome sequencing technologies is a central challenge faced by human geneticists today.
Hernandez, Ryan D. +3 more
core +2 more sources
Nature Communications, 2016 Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its ...
A. Barbeira +260 more
semanticscholar +1 more source
Assessment of Five Chilling Tolerance Traits and GWAS Mapping in Rice Using the USDA Mini-Core Collection [PDF]
, 2017 Rice (Oryza sativa L.) is often exposed to cool temperatures during spring planting in temperate climates. A better understanding of genetic pathways regulating chilling tolerance will enable breeders to develop varieties with improved tolerance during ...
Boykin, Debbie L. +7 more
core +3 more sources
Genetics of coronary artery disease in the post‐GWAS era
Journal of Internal Medicine, 2021 During the past decade, genome‐wide association studies (GWAS) have transformed our understanding of many heritable traits. Three recent large‐scale GWAS meta‐analyses now further markedly expand the knowledge on coronary artery disease (CAD) genetics in
Zhifen Chen, H. Schunkert
semanticscholar +1 more source
Biomedical Research, A Tool to Address the Health Issues that Affect African Populations. [PDF]
, 2013 Traditionally, biomedical research endeavors in low to middle resources countries have focused on communicable diseases. However, data collected over the past 20 years by the World Health Organization (WHO) show a significant increase in the number of ...
Peprah, Emmanuel, Wonkam, Ambroise
core +3 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Tobacco Induced DiseasesIntroduction It is currently uncertain whether smoking is a risk factor for carpal tunnel syndrome (CTS). This study aims to elucidate association between smoking and CTS using Mendelian randomization (MR) analysis.
Wei Shi+ +3 more
doaj +1 more source
Maximum difference analysis: a new empirical method for genome-wide association studies
Italian Journal of Animal Science, 2016 The availability of high-density single nucleotide polymorphism (SNPs) panels for humans and, recently, for several livestock species has given a great impulse to genome-wide association studies towards the identification of genes associated with complex
Massimo Cellesi +6 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2020 Linkage and association mapping populations are crucial public resources that facilitate the characterization of trait genetic architecture in natural and agricultural systems.
Marcus T. Brock +3 more
doaj +1 more source
The contribution of non-coding regulatory elements to cardiovascular disease [PDF]
Open Biology, 2020 Cardiovascular disease collectively accounts for a quarter of deaths worldwide. Genome-wide association studies across a range of cardiovascular traits and pathologies have highlighted the prevalence of common non-coding genetic variants within candidate
Diego Villar +3 more
doaj +1 more source