Results 71 to 80 of about 274,572 (340)

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Multiple testing correction in linear mixed models. [PDF]

, 2016
BackgroundMultiple hypothesis testing is a major issue in genome-wide association studies (GWAS), which often analyze millions of markers. The permutation test is considered to be the gold standard in multiple testing correction as it accurately takes ...
Eskin, Eleazar, Han, Buhm, Hormozdiari, Farhad, Joo, Jong Wha J   +3 more
core   +2 more sources

Uncovering genomic regions controlling plant architectural traits in hexaploid wheat using different GWAS models

Scientific Reports, 2021
Wheat is a major food crop worldwide. The plant architecture is a complex trait mostly influenced by plant height, tiller number, and leaf morphology. Plant height plays a crucial role in lodging and thus affects yield and grain quality. In this study, a
A. Muhammad, Jianguo Li, Weicheng Hu, Jinsheng Yu, S. Khan, M. H. U. Khan, G. Xie, Jibin Wang, Lingqiang Wang   +8 more
semanticscholar   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

The Population Genetic Signature of Polygenic Local Adaptation

, 2014
Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals.
Berg, Jeremy J., Coop, Graham
core   +3 more sources

Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data [PDF]

, 2019
BACKGROUND: Genome imputation, admixture resolution and genome-wide association analyses are timely and computationally intensive processes with many composite and requisite steps.
Eller, Ryan J., Janga, Sarath C., Walsh, Susan   +2 more
core   +1 more source

Network analysis of GWAS data [PDF]

Current Opinion in Genetics & Development, 2013
Genome-wide association studies (GWAS) identify genetic variants that distinguish a control population from a population with a specific trait. Two challenges in GWAS are: (1) identification of the causal variant within a longer haplotype that is associated with the trait; (2) identification of causal variants for polygenic traits that are caused by ...
Mark D M, Leiserson, Jonathan V, Eldridge, Sohini, Ramachandran, Benjamin J, Raphael   +3 more
openaire   +2 more sources

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

Advanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu, Yuqi He, Wenfeng Weng, Zebin Liu, Yuanfen Gao, Yaliang Shi, Wei Li, Dili Lai, Mengyu Zhao, Rintu Jha, Hui Zhao, Guangsheng Li, Chaonan Guan, Shuai Shao, Jingjun Ruan, Sun Hee Woo, Yinan Ouyang, Muriel Quinet, Milen I. Georgiev, Alisdair R. Fernie, Congcong Hou, Kaixuan Zhang, Xu Liu, Meiliang Zhou   +23 more
wiley   +1 more source

Integrative analysis across 3,604 GWAS reveals multiple novel cell type-specific regulatory associations

, 2021
Charles E. Breeze
openalex   +2 more sources

Don't give up on GWAS [PDF]

Molecular Psychiatry, 2011
Buitelaar J, Bulik CM, Cichon S, Collier D, Corvin A, Craddock N, DeLisi LE, Ebstein R, Edenberg HJ, Estivill X, Faraone SV, Farmer AE, Fernandez-Aranda F, Flint J, Foroud T, Franke B, Gelernter J, Gill M, Grabe HJ, Hamilton SP, Hickie IB, Hoogendijk W, Jablensky A, Kalaydjieva L, Kaprio J, Kas M, Keller M, Kelsoe J, Kendler KS, Kennedy M, Kent L ...
Sullivan, P., Andreassen, Ole A, Anney, Richard J L, Asherson, Philip, Ashley-Koch, Allison, Blackwood, Douglas, Boomsma, Dorret I, Breen, Gerome, Buitelaar, Jan, Bulik, Cynthia M, Cichon, Sven, Collier, David, Corvin, Aiden, Craddock, Nicholas, DeLisi, Lynn E, Ebstein, Richard, Edenberg, Howard J, Estivill, Xavier, Faraone, Stephen V, Farmer, Anne E, Fernandez-Aranda, Fernando, Flint, Jonathan, Foroud, Tatiana, Franke, Barbara, Gelernter, Joel, Gill, Michael, Grabe, Hans J, Hamilton, Steven P, Hickie, Ian B, Hoogendijk, Witte, Jablensky, Assen, Kalaydjieva, Luba, Kaprio, Jaakko, Kas, Martien, Keller, Matthew, Kelsoe, John, Kendler, Kenneth S, Kennedy, Martin, Kent, Lindsey, Klump, Kelly, Knowles, James A, Levinson, Douglas F, Lewis, Cathryn M, Lichtenstein, Paul, Lucae, Susanne, Martin, Nicholas G, McCarroll, Steve, McGough, James, McGrath, John J, McGuffin, Peter, Mitchell, Philip, Mowry, Bryan, Muglia, Pierandrea, Müller-Myhsok, Bertram, Neale, Benjamin, Nöthen, Markus, Nurnberger, John I, Oades, Robert D., O'Donovan, Michael, Ophoff, Roel, Owen, Michael, Pato, Carlos N, Pato, Michele T, Penninx, Brenda W, Perlis, Roy H, Porjesz, Bernice, Posthuma, Danielle, Potash, James B, Preisig, Martin, Reichborn-Kjennerud, Ted, Rice, John P, Rietschel, Marcella, Riley, Brien, Ripke, Stephan, Rothenberger, Aribert, Rujescu, Dan, Santangelo, Susan L, Schachar, Russell, Schellenberg, Gerard D, Scherer, Stephen W, Schofield, Peter, Schulze, Thomas G, Sklar, Pamela, Smoller, Jordan W, Stefansson, Hreinn, Stefansson, Kari, Todorov, Alexandre, Tozzi, Federica, Tzeng, Jung-Ying, van den Oord, Edwin J. C. G., Vorstman, Jacob A S, Wang, Kai, Weissman, Myrna M, Werge, Thomas, Wray, Naomi R, Zeggini, Eleftheria   +95 more
openaire   +5 more sources