Results 81 to 90 of about 274,572 (340)

A Pan‐TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions

Advanced Science, EarlyView.
This study presents the first pan‐transposable element (TE) atlas in rapeseed, profiling over 8 million TEs across 2311 accessions. Integrative analyses reveal that TEs broadly shape gene expression through diverse regulatory mechanisms, with key insertions in BnaA03.FLC and BnaA09.CYP78A9 linked to flowering time and silique development.
Zhiquan Yang, Haiyan Fan, Yifan Chen, Jiawei Li, Minjian Chen, Yingying Tan, Liang Guo, Jintao Li, Kede Liu, Qing‐Yong Yang   +9 more
wiley   +1 more source

Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes [PDF]

, 2022
Eriko Sasaki, Joanna Gunis, Ilka Reichardt, Viktoria Nizhynska, Magnus Nordborg   +4 more
openalex   +1 more source

Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]

, 2018
Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W, Björkegrenn, Johan L.M, de Bakker, Paul I.W, de Borst, Gert J., den Ruijter, Folkert W, Dichgans, Martin, Erdmann, Jeanette, Ford, Ian, Foroughi Asl, Hassan, Haitjema, Saskia, Hedin, Ulf, Malik, Rainer, Mokry, Michal, Pasterkamp, Gerard, Paulsson-Berne, Gabrielle, Perisic, Ljubica, Samani, Nilesh J, Sattar, Naveed, Schunkert, Heribert, Siemelink, Marten A., Stott, David J., van der Laan, Sander W., van Setten, Jessica, Worrall, Bradford B   +23 more
core   +2 more sources

GWAS on family history of Alzheimer’s disease

bioRxiv, 2018
Alzheimer’s disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biological underpinnings.
R. Marioni, S. Harris, Qian Zhang, A. McRae, S. Hagenaars, S. Hagenaars, W. Hill, G. Davies, C. Ritchie, C. Gale, C. Gale, J. Starr, A. Goate, D. Porteous, Jian Yang, K. Evans, I. Deary, N. Wray, P. M. Visscher, P. M. Visscher   +19 more
semanticscholar   +1 more source

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

bioRxiv, 2020
Genome-wide association studies (GWAS) have been used to study the genetic basis of a wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for three molecular traits—urate, IGF-1, and testosterone—with better-understood ...
Nasa Sinnott-Armstrong, S. Naqvi, M. Rivas, J. Pritchard   +3 more
semanticscholar   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Genome-wide association studies (GWAS) vs functional validation: the challenge of the post-GWAS era [PDF]

, 2023
Susana Balcells, Núria Martínez‐Gil, Juan David Patiño-Salazar, Raquel Rabionet, Daniel Grinberg   +4 more
openalex   +1 more source

The advantages and limitations of trait analysis with GWAS: a review

Plant Methods, 2013
Over the last 10 years, high-density SNP arrays and DNA re-sequencing have illuminated the majority of the genotypic space for a number of organisms, including humans, maize, rice and Arabidopsis.
A. Korte, Ashley Farlow
semanticscholar   +1 more source

Give GWAS a Chance [PDF]

Diabetes, 2017
From 2007 to 2015, genome-wide association studies (GWAS) resulted in the discovery of over 260 genetic loci associated with obesity and type 2 diabetes (T2D) (1,2). Although GWAS have validated “old culprits” (e.g., PPARG , KCNJ11 ), illuminated novel disease-causing biological pathways (e.g., the zinc transporter SLC30A8 ), and have led to quick ...
openaire   +2 more sources