Covalent Targeting of the Vacuolar H+-ATPase Activates Autophagy Via mTORC1 Inhibition [PDF]
Nature Chemical Biology, 2019 Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting ...
C. Y. Chung +7 more
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Physiological implications of the regulation of vacuolar H+-ATPase by chloride ions [PDF]
Brazilian Journal of Medical and Biological Research, 2009 Vacuolar H+-ATPase is a large multi-subunit protein that mediates ATP-driven vectorial H+ transport across the membranes. It is widely distributed and present in virtually all eukaryotic cells in intracellular membranes or in the plasma membrane of ...
L.R. Carraro-Lacroix +3 more
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Iron nanoparticle-induced activation of plasma membrane H(+)-ATPase promotes stomatal opening in Arabidopsis thaliana. [PDF]
Environmental Science and Technology, 2015 Engineered nanomaterials (ENMs) enable the control and exploration of intermolecular interactions inside microscopic systems, but the potential environmental impacts of their inevitable release remain largely unknown.
Jae-hwan Kim +4 more
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Promotion and Upregulation of a Plasma Membrane Proton-ATPase Strategy: Principles and Applications
Frontiers in Plant Science, 2021 Plasma membrane proton-ATPase (PM H+-ATPase) is a primary H+ transporter that consumes ATP in vivo and is a limiting factor in the blue light-induced stomatal opening signaling pathway.
Zirong Ren +6 more
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Enhanced expression of vacuolar H+-ATPase subunit E in the roots is associated with the adaptation of Broussonetia papyrifera to salt stress. [PDF]
PLoS ONE, 2012 Vacuolar H(+)-ATPase (V-H(+)-ATPase) may play a pivotal role in maintenance of ion homeostasis inside plant cells. In the present study, the expression of V-H(+)-ATPase genes was analyzed in the roots and leaves of a woody plant, Broussonetia papyrifera,
Min Zhang +3 more
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Wheat V-H+-ATPase subunit genes significantly affect salt tolerance in Arabidopsis thaliana. [PDF]
PLoS ONE, 2014 Genes for V-H(+)-ATPase subunits were identified and cloned from the salt-tolerant wheat mutant RH8706-49. Sequences of these genes are highly conserved in plants.
Xiaoliang He +3 more
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A win-win scenario for photosynthesis and the plasma membrane H+ pump
Frontiers in Plant Science, 2022 In plants, cytosolic and extracellular pH homeostasis are crucial for various physiological processes, including the uptake of macronutrients and micronutrients, cell elongation, cell expansion, and enzyme activity. Proton (H+) gradients and the membrane
Satoru N. Kinoshita +2 more
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Activation of H+-ATPase of the plasma membrane of Saccharomyces cerevisiae by glucose: the role of sphingolipid and lateral enzyme mobility. [PDF]
PLoS ONE, 2012 Activation of the plasma membrane H(+)-ATPase of the yeast Saccharomyces cerevisiae by glucose is a complex process that has not yet been completely elucidated.
Sergey Permyakov +2 more
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Plant Plasma Membrane Proton Pump: One Protein with Multiple Functions
Cells, 2022 In plants, the plasma membrane proton pump (PM H+-ATPase) regulates numerous transport-dependent processes such as growth, development, basic physiology, and adaptation to environmental conditions.
Adrianna Michalak +2 more
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The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease
American Journal of Physiology - Cell Physiology, 2020 A primary function of the H+-ATPase (or V-ATPase) is to create an electrochemical proton gradient across eukaryotic cell membranes, which energizes fundamental cellular processes.
A. Eaton, M. Merkulova, Dennis Brown
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