Results 101 to 110 of about 511,561 (316)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

BIOSYNTHESIS AND SUBCELLULAR LOCATION OF H-2 HISTOCOMPATIBILITY ANTIGENS OF MOUSE LIVER

, 1983
The intracellular transport and subcellular distribution of H-2 histocompatibility antigens of mouse liver were studied. Specific immunoprecipitation and immunocytochemistry were used to localize H-2 histocompatibility antigens on membranes of the ...
CROZE, EDWARD MICHAEL
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

, 2008
Alum is used as a vaccine adjuvant and induces T_h2 responses and T_h2-driven antibody isotype production against co-injected antigens.
White, Janice, Kappler, John W., McKee, Amy S., Marrack, Philippa, Macleod, Megan, P. Marrack, J. White, J. W. Kappler, F. Crawford, A. S. McKee, M. MacLeod, Crawford, Frances   +11 more
core   +1 more source

The Distributions of Duffy Antigens and Phenotypes Among Blood Donors in King Abdulaziz Medical City-Western Region, Saudi Arabia: A Cross-Sectional Study

International Journal of General Medicine
Amr J Halawani,1 Sahal A Jamalallail,2 Abdullah M Algarni,2 Mohammad H Alsomali,2 Sulaiman S Alabsi,2 Ammar M Sahl,2 Afnan T Kumosani,2 Saja M Asali,2 Alaa H Qudayr,2 Banan A Mallah,2 Ahmed A Mari,2 Hiam O Mulla,3– 5 Ali H Alhussain Snr,6 Sarah M Alahwal,
Halawani AJ, Jamalallail SA, Algarni AM, Alsomali MH, Alabsi SS, Sahl AM, Kumosani AT, Asali SM, Qudayr AH, Mallah BA, Mari AA, Mulla HO, Alhussain Snr AH, Alahwal SM, Alomari FD   +14 more
doaj  

Pneumocystis Jirovecii Pneumonia: The Potential of KEX1, MSG1, and MSG2 as Key Antigens in Cytokine Release Assays

Diagnostics
Background/Objectives: Pneumocystis jirovecii pneumonia (PJP) is the most frequently diagnosed AIDS-defining illness in Europe, with especially high mortality in HIV-negative patients caused by delayed diagnosis and low awareness.
F. A. Ottilie Neumann, Markus Müller, Gregor Mattert, Sven Liebig, Victor Herbst, Dorinja Zapf, Til R. Kiderlen, Christian Linke, Franziska Arp, P. Markus Deckert, Stefan Lüth, Sandra Schwarzlose-Schwarck, Werner Dammermann, Mark Reinwald   +13 more
doaj   +1 more source

Human milk sIgA molecules contain various combinations of different antigen-binding sites resulting in a multiple binding specificity of antibodies and enzymatic activities of abzymes.

PLoS ONE, 2012
In the classic paradigm, immunoglobulins are monospecific molecules that have stable structures and two or more identical antigen-binding sites. However, we show here for the first time that the sIgA pool of human milk contains, depending on the donor ...
Sergey E Sedykh, Valentina N Buneva, Georgy A Nevinsky   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]

, 1987
We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by ...
Reddehase, Matthias J., Münch, Konrad, Koszinowski, Ulrich H., Mutter, Wolfgang, Bühring, Hans-Jörg   +4 more
core  

Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission [PDF]

, 2016
BACKGROUND: Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa.
Scoles, Glen A., Stephen Mwaura, Odongo, David O., Glen A. Scoles, David O. Odongo, Olds, Cassandra L., David Odongo (3497480), Richard Bishop (59737), Richard Bishop, Claudia Daubenberger (212658), Glen Scoles (3448283), Daubenberger, Claudia, Stephen Mwaura (3485219), Bishop, Richard, Cassandra L. Olds, Mwaura, Stephen, Claudia Daubenberger, Cassandra Olds (3485216)   +17 more
core   +1 more source