Results 101 to 110 of about 717,888 (354)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Human milk sIgA molecules contain various combinations of different antigen-binding sites resulting in a multiple binding specificity of antibodies and enzymatic activities of abzymes.

PLoS ONE, 2012
In the classic paradigm, immunoglobulins are monospecific molecules that have stable structures and two or more identical antigen-binding sites. However, we show here for the first time that the sIgA pool of human milk contains, depending on the donor ...
Sergey E Sedykh, Valentina N Buneva, Georgy A Nevinsky   +2 more
doaj   +1 more source

Immunology: Antigens associated with H-2, embryos and tumours [PDF]

, 1983
Elizabeth Simpson
openalex   +1 more source

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]

, 2007
We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Andó, István, Csorba, Kinga, Gateff, Elisabeth, Hultmark, Dan, Kurucz, Éva, Laurinyecz, Barbara, Márkus, Róbert, Vilmos, Péter, Váczi, Balázs, Zsámboki, János   +9 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Pneumocystis Jirovecii Pneumonia: The Potential of KEX1, MSG1, and MSG2 as Key Antigens in Cytokine Release Assays

Diagnostics
Background/Objectives: Pneumocystis jirovecii pneumonia (PJP) is the most frequently diagnosed AIDS-defining illness in Europe, with especially high mortality in HIV-negative patients caused by delayed diagnosis and low awareness.
F. A. Ottilie Neumann, Markus Müller, Gregor Mattert, Sven Liebig, Victor Herbst, Dorinja Zapf, Til R. Kiderlen, Christian Linke, Franziska Arp, P. Markus Deckert, Stefan Lüth, Sandra Schwarzlose-Schwarck, Werner Dammermann, Mark Reinwald   +13 more
doaj   +1 more source

Genomic Surveillance of 4CMenB Vaccine Antigenic Variants among Disease-Causing Neisseria meningitidis Isolates, United Kingdom, 2010–2016

Emerging Infectious Diseases, 2018
In September 2015, 4CMenB meningococcal vaccine was introduced into the United Kingdom infant immunization program without phase 3 trial information.
Charlene M.C. Rodrigues, Jay Lucidarme, Ray Borrow, Andrew Smith, J. Claire Cameron, E. Richard Moxon, Martin C.J. Maiden   +6 more
doaj   +1 more source

The absence of H-2 antigens from mouse pancreatic beta-cells demonstrated by immunoferritin labeling. [PDF]

, 1979
Earl L. Parr
openalex   +1 more source

Animals bearing malignant grafts reject normal grafts that express through gene transfer the same antigen. [PDF]

, 1990
Breaking the state of immunological unresponsiveness of tumor-bearing individuals to cancer is a prerequisite for active or passive tumor-specific immunotherapy.
Koeppen, H, Perdrizet, GA, Ross, SR, Schreiber, H, Singh, S, Stauss, HJ   +5 more
core