Results 241 to 250 of about 511,561 (316)

The Endocytic Receptor DEC205 Is Expressed by Brain Endothelial Cells and Is Involved in Regulating the Blood-Brain Barrier. [PDF]

Cells
Singh S, Ring S, Lei X, Alabdullah M, Inaba Y, Enk A, Mahnke K.   +6 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Genetic diversity in RHD and RHCE genes among a selected Kenyan blood donor population. [PDF]

Transfusion
Sowah SA, Perros AJ, Githiomi R, Lopez GH, Obiero C, Perera TN, Roulis E, Flower RL, Hyland CA.   +8 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Evaluation of an In-House Developed Foot-and-Mouth Disease Virus SAT 3 Vaccine Strain Based on Antigen Productivity and Inactivation Kinetics for Commercial Feasibility. [PDF]

Vaccines (Basel)
Kim JY, Park SY, Lee G, Cho G, Hwangbo SA, Park JH, Ko YJ.   +6 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Cattle Immunization with T7 Phage-Displayed Whole-Tick Antigens Reduces <i>Amblyomma americanum</i> Feeding Efficiency and Blocks Larval Tick Hatching. [PDF]

Pathogens
Ansari MA, Gaithuma AK, Nguyen TT, Kim WTH, Bencosme-Cuevas E, Berry J, Fridley J, Lohmeyer K, Koziol ME, Mulenga A.   +9 more
europepmc   +1 more source

Oral administration of recombinant Lactobacillus plantarum co expressing FimB, CnaA, NetB and FBA antigens targeting chicken dendritic cells provides effective protection against necrotizing enteritis in broilers. [PDF]

Poult Sci
Yang T, Wang T, Zhang G, Guo Q, Zhang Y, Gao Y, Sun Y, Zhang Y, Wen X, Lu X, Xu Y, Wang Y, Du L, Huang H, Zou S, Wang Z, Wang C, Jiang Y.   +17 more
europepmc   +1 more source

Pneumococcal membrane particles promote serotype-independent cellular and humoral immunity and protect against pneumococcal colonization. [PDF]

Proc Natl Acad Sci U S A
Dookie R, Narciso AR, Gaytán MO, Narayana Moorthy A, Chakraborty S, Thorsdottir S, Boss J, Righetti F, Karlsson J, Heurgren M, Normark S, Henriques-Normark B.   +11 more
europepmc   +1 more source