Results 91 to 100 of about 7,321 (260)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Pseudo-timelike loops in signature changing semi-Riemannian manifolds with a transverse radical
Results in PhysicsIn 1983, Hartle and Hawking proposed the no-boundary proposal, suggesting that the universe has no beginning in the sense of a spacetime singularity or boundary. Nevertheless, there is an origin of time.
N.E. Rieger, W. Hasse
doaj +1 more source
A survey on the Theorem of Chekhanov
, 2009 The theorem of Chekhanov asserts that a Lagrangian submanifold L has positive displacement energy under natural assumptions on the symplectic topology at infinity. It is greater than or equal to the minimal area of holomorphic disks bounded by L.
Tonnelier, Benoit
core +1 more source
Tangles of superpositions and the convex-roof extension
, 2007 We discuss aspects of the convex-roof extension of multipartite entanglement measures, that is, $SL(2,\CC)$ invariant tangles. We highlight two key concepts that contain valuable information about the tangle of a density matrix: the {\em zero-polytope ...
Andreas Osterloh +4 more
core +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
The number of roots in a simply-connected $H$-manifold [PDF]
Transactions of the American Mathematical Society, 1972 Brown, Robert F., Stern, Ronald J.
openaire +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Compact Riemannian Manifolds with Homogeneous Geodesics
Symmetry, Integrability and Geometry: Methods and Applications, 2009 A homogeneous Riemannian space (M = G/H,g) is called a geodesic orbit space (shortly, GO-space) if any geodesic is an orbit of one-parameter subgroup of the isometry group G. We study the structure of compact GO-spaces and give some sufficient conditions
Dmitrii V. Alekseevsky +1 more
doaj +1 more source