Results 41 to 50 of about 4,465 (182)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Epidemiological profile of acute antihistamine poisonings recorded by the Poison Control Center of the Mohamed Lamine Debaghine University Hospital, Bab El Oued – Algeria (2020-2023). [PDF]

Batna Journal of Medical Sciences
Introduction. Acute antihistamine poisoning is gaining increasing attention in toxicology due to its rising incidence. This study aims to describe the epidemiological profile of acute antihistamine poisoning cases recorded at the Poison Control Center
Chanez BOUMZAR, Lyna LAROUSSI, Salima ETTAIEB ERRAHMANI, Radia ZAMOUM, Salma KADDOUR   +4 more
doaj   +1 more source

H1 Antihistamines: Current Status and Future Directions [PDF]

World Allergy Organization Journal, 2008
In this review, we compare and contrast the clinical pharmacology, efficacy, and safety of first-generation H1 antihistamines and second-generation H1 antihistamines. First-generation H1 antihistamines cross the blood-brain barrier, and in usual doses, they potentially cause sedation and impair cognitive function and psychomotor performance.
Simon, F Estelle R, Simons, Keith J
openaire   +4 more sources

Rebound Pruritus and Urticaria After Discontinuation of Chronic Antihistamine Use—A Scoping Review

Clinical &Experimental Allergy, EarlyView.
Rebound pruritus and urticaria have been reported after discontinuation of chronic cetirizine or levocetirizine use only. Symptoms typically occur within 0.5–5 days after stopping therapy and appear more frequently reported in female patients. Re‐initiation of antihistamines is the most commonly effective management strategy, highlighting the need for ...
Jun Jie Benjamin Seng, Prawira Oka, Ngiap Chuan Tan   +2 more
wiley   +1 more source

Histamine H1 antagonists and clinical characteristics of febrile seizures

International Journal of General Medicine, 2012
Mohammed A ZolalyDepartment of Pediatrics, College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi ArabiaBackground: The purpose of this study was to determine whether seizure susceptibility due to antihistamines is provoked in ...
Zolaly MA
doaj  

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Critical appraisal of bepotastine in the treatment of ocular itching associated with allergic conjunctivitis

Clinical Ophthalmology, 2011
Jeremy B Wingard, Francis S MahUPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAAbstract: Bepotastine besilate 1.5% solution is an H1-antihistamine recently approved by the Food and Drug ...
Jeremy B Wingard, Francis S Mah
doaj  

Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats

Journal of Pharmacological Sciences, 2016
Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of ...
Hiroyuki Mizuguchi, Asish K. Das, Kazutaka Maeyama, Shrabanti Dev, Masum Shahriar, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui   +7 more
doaj   +1 more source

Primary Non-Adherence to Antihistamines—Conclusions From E-Prescription Pilot Data in Poland

Frontiers in Pharmacology, 2020
BackgroundIn allergic conditions such as allergic rhinitis and urticaria, orally administered H1-antihistamines belong to first-line therapy and therefore, are widely prescribed.
Grzegorz Kardas, Michał Panek, Piotr Kuna, Janusz Cieszyński, Przemysław Kardas   +4 more
doaj   +1 more source

Antihistaminic, Anti-Inflammatory, and Antiallergic Properties of the Nonsedating Second-Generation Antihistamine Desloratadine: a Review of the Evidence

World Allergy Organization Journal, 2011
The allergy cascade presents widespread inflammatory and proinflammatory activation, robust cytokine and chemokine signaling, and heterogeneous immune and endothelial responses that lead ultimately to the manifestations of allergic reaction. Histamine, a
G. Walter Canonica, MD, Michael Blaiss, MD   +1 more
doaj   +1 more source