Results 51 to 60 of about 108,387 (211)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2

mBio
Numerous host factors, in addition to human angiotensin-converting enzyme 2 (hACE2), have been identified as coreceptors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), demonstrating broad viral tropism and diversified druggable ...
Fei Yu, Xiaoqing Liu, Hailan Ou, Xinyu Li, Ruxin Liu, Xi Lv, Shiqi Xiao, Meilin Hu, Taizhen Liang, Tao Chen, Xuepeng Wei, Zhenglai Zhang, Sen Liu, Han Liu, Yiqiang Zhu, Guangyan Liu, Tianyong Tu, Peiwen Li, Hui Zhang, Ting Pan, Xiancai Ma   +20 more
doaj   +1 more source

Therapeutic effect of bilastine in Japanese cedar pollinosis using an artificial exposure chamber (OHIO Chamber)

Allergology International, 2017
Background: Environmental exposure chambers have been used to expose subjects to aeroallergens to investigate the efficacy of prophylactic treatment with symptomatic agents in Japan.
Kazuhiro Hashiguchi, Ken-ichiro Wakabayashi, Michinori Togawa, Akihiro Saito, Kimihiro Okubo   +4 more
doaj   +1 more source

Successful treatment of idiopathic cold urticaria with the association of H1 and H2 antagonists: a case report

, 1986
We report here the case of a patient suffering from idiopathic cold urticaria who did not respond to H1 antihistamine but who responded dramatically to the combination of H1 and H2 antagonists.
Pecoud, A., Duc, J.
core   +1 more source

Epidemiological profile of acute antihistamine poisonings recorded by the Poison Control Center of the Mohamed Lamine Debaghine University Hospital, Bab El Oued – Algeria (2020-2023). [PDF]

Batna Journal of Medical Sciences
Introduction. Acute antihistamine poisoning is gaining increasing attention in toxicology due to its rising incidence. This study aims to describe the epidemiological profile of acute antihistamine poisoning cases recorded at the Poison Control Center
Chanez BOUMZAR, Lyna LAROUSSI, Salima ETTAIEB ERRAHMANI, Radia ZAMOUM, Salma KADDOUR   +4 more
doaj   +1 more source

Suppression of endotoxin-induced corticosterone secretion in rats by H1-antihistamine

, 1985
Corticosterone (CS) secretion is stimulated in rats by an intraperitoneal injection of bacterial lipopolysaccharide (LPS) or by subjecting the animals to immobilization stress. LPS injection caused a significant increase in the lung histamine level and a
S. Suzuki, K. Nakano
core   +1 more source

Desloratadine and loratadine stand out among common H1-antihistamines for association with improved breast cancer survival

, 2020
Background: As tumors maintain an inflammatory microenvironment, anti-inflammatory medication can be useful in cancer therapy. We have previously shown an association with improved survival in melanoma for use of the H1-antihistamines desloratadine and ...
Einefors, Rickard, Broberg, Per, Fritz, Ildikó, Wagner, Philippe, Olsson, Håkan, Wagner, Philippe,, Broberg, Per,, Olsson, Håkan,, Fritz, Ildikó,, Lund University., Einefors, Rickard,   +10 more
core   +2 more sources

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats

Journal of Pharmacological Sciences, 2016
Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of ...
Hiroyuki Mizuguchi, Asish K. Das, Kazutaka Maeyama, Shrabanti Dev, Masum Shahriar, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui   +7 more
doaj   +1 more source

Treatment of chronic spontaneous urticaria with an inadequate response to H1-antihistamine

, 2019
The second-generation H1-antihistamines (sgAH) are the first-line symptomatic treatment of patients with chronic spontaneous urticaria (CSU). Up to 50% of the patients will not respond to licensed doses of sgAH.
Curto-Barredo, Laia, Giménez Arnau, Anna Maria   +1 more
core   +1 more source