Results 61 to 70 of about 88,273 (209)

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Host Modulators of H1N1 Cytopathogenicity

PLoS ONE, 2012
Influenza A virus infects 5-20% of the population annually, resulting in ~35,000 deaths and significant morbidity. Current treatments include vaccines and drugs that target viral proteins. However, both of these approaches have limitations, as vaccines require yearly development and the rapid evolution of viral proteins gives rise to drug resistance ...
Ward, Samuel E, Kim, Hyun Seok, Komurov, Kakajan, Mendiratta, Saurabh, Tsai, Pei-Ling, Schmolke, Mirco, Satterly, Neal, Manicassamy, Balaji, Forst, Christian V, Roth, Michael G, García-Sastre, Adolfo, Blazewska, Katarzyna M, McKenna, Charles E, Fontoura, Beatriz M, White, Michael A   +14 more
openaire   +5 more sources

Two‐Dimensional Materials For Lateral Flow Assays: A Critical Review of Functional Roles and Translational Challenges

VIEW, EarlyView.
2D nanosheets, with large surface area, excellent optical/electrical properties, and high specificity, combine with lateral flow assay strips to enable rapid, readable detection, boosting the strips’ development and applications. Abstract Lateral flow assays (LFAs) are widely used for point‐of‐care diagnostics, but their detection capability remains ...
Weimin Xu, Ruping Liu, Na Gao, Jianxiao Zhu, Haowen Jiang, Shouzheng Jiao, Zhicheng Sun, Kai Shen, Gaolian Xu, Minghua Du, Ziyan Li, Yang Wang   +11 more
wiley   +1 more source

Surveillance of hospitalizations with pandemic A(H1N1) 2009 influenza infection in Queensland, Australia

Western Pacific Surveillance and Response, 2011
Objective: To describe the demographic and clinical characteristics of patients hospitalized with pandemic A(H1N1) 2009 infection in Queensland, Australia between 25 May and 3 October 2009 and to examine the relationship between timing of antiviral ...
Hai Phung, Frank Beard, Christine Selvey, Ranil Appuhamy, Frances Birrell   +4 more
doaj   +1 more source

Narcolepsy and H1N1 vaccination

Current Opinion in Pulmonary Medicine, 2013
A number of European countries have reported a dramatic increase in the rates of childhood narcolepsy with cataplexy in children immunized with a split-virion adjuvanted swine flu vaccine. Here, we review the strengths and weaknesses of these epidemiological studies and possible neuroimmunological mechanisms.Initial concerns of a 13-fold increased ...
Thebault, Simon, Vincent, Angela, Gringras, Paul   +2 more
openaire   +3 more sources

Strategies for enhancing sensitivity in lateral flow assays

VIEW, EarlyView.
Lateral flow assays (LFAs) are essential for cost‐effective, rapid point‐of‐care diagnostics. However, conventional colourimetric LFAs often lack the sensitivity required for low‐abundance biomarkers. This review evaluates six enhancement strategies: flow modulation, sample preconcentration, advanced reporters, chemical signal amplification, structural
Aylar Eslami Saed, Jacopo Giaretta, Syamak Farajikhah, Fariba Dehghani   +3 more
wiley   +1 more source

Crisis micro‐learning: A framework for understanding the micro‐flow of policy learning and Australia's COVID‐19 response

Australian Journal of Public Administration, EarlyView.
Abstract COVID‐19 has intensified interest in crisis policy learning, yet the micro‐level interactions among political, bureaucratic, and expert actors remain underexplored. We conceptualise an ideal‐type framework for the micro‐flow of crisis learning, an ordinarily epistemic and context‐specific process of individual‐level interactions, where lessons
Neil Mortimer, Nicholas Bromfield
wiley   +1 more source

Structured Antenatal Counselling Improves Maternal Influenza and Pertussis Uptake: A Prospective Comparative Study in Greece

Acta Paediatrica, EarlyView.
ABSTRACT Aim Maternal immunization is essential for preventing severe influenza and pertussis in pregnant women and young infants. Despite clear recommendations, uptake in Greece remains suboptimal, and evidence on effective antenatal interventions is limited.
A. Drougia, F. Ladomenou, E. Sourla, A. Klapas, P. Pappa, C. Skendou, M. Paschopoulos, V. Giapros   +7 more
wiley   +1 more source

Characteristics and outcome of ill critical patients with influenza A infection

The Pan African Medical Journal, 2018
INTRODUCTION: To describe all patients admitted to Tunisian intensive care unit with a diagnosis of influenza A/H1N1 virus infection after the 2009 influenza pandemic and to analyse their characteristics, predictors of complications and outcome. METHODS:
Rania Bouneb, Manel Mellouli, Houda Bensoltane, Jamila Baroudi, Imed chouchene, Mohamed Boussarsar   +5 more
doaj   +1 more source

Historical H1N1 Influenza Virus Imprinting Increases Vaccine Protection by Influencing the Activity and Sustained Production of Antibodies Elicited at Vaccination in Ferrets

Vaccines, 2019
Influenza virus imprinting is now understood to significantly influence the immune responses and clinical outcome of influenza virus infections that occur later in life.
Magen E. Francis, Mara McNeil, Nicholas J. Dawe, Mary K. Foley, Morgan L. King, Ted M. Ross, Alyson A. Kelvin   +6 more
doaj   +1 more source