H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation. [PDF]
PLoS Genetics, 2013 The histone H2A variant H2A.Z is essential for embryonic development and for proper control of developmental gene expression programs in embryonic stem cells (ESCs).
Vidya Subramanian +10 more
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Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex [PDF]
eLife, 2016 The assembly of the preinitiation complex (PIC) occurs upstream of the +1 nucleosome which, in yeast, obstructs the transcription start site and is frequently assembled with the histone variant H2A.Z.
Michael Tramantano +7 more
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SWR1-Independent Association of H2A.Z to the LINC Complex Promotes Meiotic Chromosome Motion [PDF]
Frontiers in Cell and Developmental Biology, 2020 The H2A.Z histone variant is deposited into the chromatin by the SWR1 complex, affecting multiple aspects of meiosis. We describe here a SWR1-independent localization of H2A.Z at meiotic telomeres and the centrosome. We demonstrate that H2A.Z colocalizes
Sara González-Arranz +10 more
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The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity [PDF]
Nature Communications, 2019 Arabidopsis H2A.Z plays an important role in regulating gene expression in response to stressors; however, the underlying mechanism is still puzzling.
Ángeles Gómez-Zambrano +2 more
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Histone H2A.Z Suppression of Interferon-Stimulated Transcription and Antiviral Immunity Is Modulated by GCN5 and BRD2 [PDF]
iScience, 2018 Summary: Type I interferon (IFN)-stimulated gene (ISG) expression requires interaction between a transcription factor complex, ISGF3, and target gene promoters to initiate transcription and protection against infection.
Nancy Au-Yeung, Curt M. Horvath
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H2A.Z deposition by the SWR complex is stimulated by polyadenine DNA sequences in nucleosomes. [PDF]
PLoS BiologyThe variant histone H2A.Z is deposited into nucleosomes immediately downstream of promoters, where it plays a critical role in transcription. The site-specific deposition of H2A.Z is catalyzed by the SWR complex, a conserved chromatin remodeler with ...
Cynthia Converso +7 more
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Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome [PDF]
mBioChromatin structure plays a central role in the regulation of Epstein-Barr virus (EBV) latency. The histone variant H2A.Z.1 has been implicated in chromatin structures associated with the initiation of transcription and DNA replication.
Leonardo Josué Castro-Muñoz +5 more
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H3K4me3 binding ALFIN-LIKE proteins recruit SWR1 for gene-body deposition of H2A.Z [PDF]
Genome BiologyBackground The H2A.Z histone variant is highly enriched over gene bodies, playing an essential role in several genome-templated processes, including transcriptional regulation and epigenetic patterning across eukaryotes.
Linhao Xu +7 more
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Major waves of H2A.Z incorporation during mouse oogenesis and preimplantation embryo development [PDF]
Nature CommunicationsEpigenomes of mammalian oocytes and embryos undergo major transitions essential for successful development. Here, we provide genome-wide maps of histone variant H2A.Z during twelve stages of mouse oogenesis and preimplantation embryo development and ...
Madeleine Fosslie +22 more
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H2A.Z primes an epigenetic landscape for memory CD8+ T cell recall response [PDF]
Nature CommunicationsThe rapid recall ability is a hallmark of memory CD8+ T cells, but the underlying mechanisms remain incompletely understood. Here we find that histone variant H2A.Z is expressed at higher levels in memory CD8+ T cells than in naïve cells. Furthermore, in
Wei Liang +10 more
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