Results 111 to 120 of about 12,258 (237)

H2A.Z and chromatin remodelling complexes: a focus on fungi

Critical Reviews in Microbiology, 2020
Chromatin is a highly dynamic structure that closely relates with gene expression in eukaryotes. ATP-dependent chromatin remodelling, histone post-translational modification and DNA methylation are the main ways that mediate such plasticity. The histone variant H2A.Z is frequently encountered in eukaryotes, and can be deposited or removed from ...
Chen, Zhenhui, Ponts, Nadia
openaire   +4 more sources

Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform

Cell Proliferation, Volume 58, Issue 12, December 2025.
We compiled a comprehensive set of ZGA genes from mice, humans, pigs, bovines and goats, demonstrating the cross‐species conservation. An interpretable machine learning model, based on k‐mer core features, accurately predicted ZGA genes, revealing abundant and intricate six‐base sequence‐specific patterns and potential binding TFs.
Jixiang Xing, Siqi Yang, Yuchao Liang, Pengwei Hu, Bingjie Dai, Hanshuang Li, Yongqiang Xing, Yongchun Zuo   +7 more
wiley   +1 more source

Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms. [PDF]

PLoS ONE, 2013
The incorporation of histone variants into nucleosomes is a critical mechanism for regulating essential DNA-templated processes and for establishing distinct chromatin architectures with specialised functions.
Thomas J Wood, Angela Thistlethwaite, Michael R Harris, Simon C Lovell, Catherine B Millar   +4 more
doaj   +1 more source

Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling [PDF]

, 2009
The (H3-H4)2 histone tetramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disassembly and positioning of nucleosomes.
Bowman, A., El-Mkami, Hassane, Norman, David G., Owen-Hughes, Tom, Ward, Richard   +4 more
core   +5 more sources

The Epigenetic Regulation of Agronomic Traits and Environmental Adaptability in Brassicas

Plant, Cell &Environment, Volume 48, Issue 12, Page 8915-8927, December 2025.
ABSTRACT As essential sources of vegetables, oilseeds, and forage, Brassica crops exhibit complex epigenetic regulation mechanisms involving histone modifications, DNA modifications, RNA modifications, noncoding RNAs, and chromatin remodelling. The agronomic traits and environmental adaptability of crops are regulated by both genetic and epigenetic ...
Daolei Zhang, Yin Lu, Wei Ma, Jianjun Zhao   +3 more
wiley   +1 more source

Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis

Cell Reports, 2015
The histone variant H2A.Z is a hallmark of nucleosomes flanking promoters of protein-coding genes and is often found in nucleosomes that carry lysine 56-acetylated histone H3 (H3-K56Ac), a mark that promotes replication-independent nucleosome turnover ...
Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Münster, Lars M. Steinmetz, Oliver J. Rando, Laurie A. Boyer, Craig L. Peterson   +10 more
doaj   +1 more source

Spatiotemporal clustering of the epigenome reveals rules of dynamic gene regulation [PDF]

, 2012
Spatial organization of different epigenomic marks was used to infer functions of the epigenome. It remains unclear what can be learned from the temporal changes of the epigenome.
He, Chuan, Huang, Wei, McDee, Darina, Song, Chun-Xiao, Tanaka, Tetsuya, Wang, Ting, Xiao, Shu, Xin, Xiaoyun, Yu, Pengfei, Zhong, Sheng   +9 more
core   +2 more sources

Non‐Random Distribution of EMS‐Induced Mutations Reveals Preference for Open Chromatin and Expressed Genes in Rice

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Mutagenesis is an effective method for generating genetic resources with a long history in breeding; however, the randomness of chemical‐induced mutations has not been systematically investigated. In this study, over 7 million SNPms are identified in an EMS‐induced population, revealing that these mutations are non‐randomly distributed and ...
Xue‐Feng Yao, Yanhong Liu, Zhiyong Li, Guo‐Qiang Jiang, Wensheng Wang, Hong Lu, Huihui Li, Zefu Lu, Chun‐Ming Liu   +8 more
wiley   +1 more source

Removal of H2A.Z by INO 80 promotes homologous recombination

EMBO reports, 2015
The mammalian INO80 remodelling complex facilitates homologous recombination (HR), but the mechanism by which it does this is unclear. Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with H2A/H2B dimers. H2A.Z is actively incorporated at sites of damage in mammalian cells, raising the possibility that H2A.Z may need to ...
Alatwi, HE, Downs, JA
openaire   +3 more sources

Factors determining chromosomal localization of transposable elements in plants

Plant Biology, Volume 27, Issue 6, Page 975-989, October 2025.
We review transposon chromosomal niches, and the functional consequences of their specific chromosomal localization in plants. Abstract Transposable elements (TEs) constitute a significant part of plant genomes and shape their genomic landscape. While some TEs are ubiquitously dispersed, other elements specifically occupy discrete genomic loci.
E. Kejnovsky, P. Jedlicka, M. Lexa, Z. Kubat   +3 more
wiley   +1 more source