Results 121 to 130 of about 12,258 (237)
Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z.
PLoS ONE, 2013 Differential positioning of the histone variant H2A.Z in a p53 dependent manner was shown to regulate p21 transcription. Whether H2A.Z is involved in p21 activity in the absence of p53 is not known.
Luca Bellucci +4 more
doaj +1 more source
A role for chromatin remodellers in replication of damaged DNA [PDF]
, 2011 In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure.
Chambers, Anna L +3 more
core +2 more sources
New Phytologist, Volume 247, Issue 6, Page 2564-2570, September 2025.Summary Jasmonates (JAs) have traditionally been studied for their defensive roles against wounding and detrimental organisms, but they are also crucial hormones for plant–microbe beneficial interactions. Here, we review the most recent advances in this overlooked field.
José Eduardo Marqués‐Gálvez +2 more
wiley +1 more source
The Histone Variant H2A.Z Is a Master Regulator of the Epithelial-Mesenchymal Transition
Cell Reports, 2017 Summary: Epithelial-mesenchymal transition (EMT) is a profound example of cell plasticity that is crucial for embryonic development and cancer. Although it has long been suspected that chromatin-based mechanisms play a role in this process, no master ...
Renae Domaschenz +4 more
doaj +1 more source
Aging Cell, Volume 24, Issue 7, July 2025.Expression of HIRA in embryonic melanoblasts is required for proper epigenetic programing and lineage differentiation. Although HIRA deficiency results in a mild phenotype at birth and young adulthood, the melanocytic lineage is sensitive to proliferative challenge, prone to loss of stem cells and dramatically accelerated hair greying in later life ...
Farah Jaber‐Hijazi +20 more
wiley +1 more source
Epigenetic regulation of Mash1 expression [PDF]
, 2010 Mash1 is a proneural gene important for specifying the neural fate. The Mash1 locus undergoes specific epigenetic changes in ES cells following neural induction.
Beretta, Chiara, Beretta, Chiara
core +1 more source
A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation
iScience, 2019 Summary: Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active regulatory regions associated with gene expression. Although the Tip60 complex is proposed to acetylate H2A.Z, functional studies suggest additional enzymes are involved.
Yolanda Colino-Sanguino +10 more
doaj +1 more source
Histone variant H2A.Z plays multiple roles in the maintenance of heterochromatin integrity [PDF]
, 2021 Kazuki Tsukii +2 more
openalex +1 more source
Characterization of Toxoplasma gondii subtelomeric-like regions: identification of a long-range compositional bias that is also associated with gene-poor regions [PDF]
, 2014 Background Chromosome ends are composed of telomeric repeats and subtelomeric regions, which are patchworks of genes interspersed with repeated elements.
Agüero, Fernan Gonzalo +3 more
core +2 more sources
H2A.Z Exchange Is Critical for DNA Repair [PDF]
Cancer Discovery, 2013 Abstract p400-mediated exchange of histone H2A.Z at double-strand breaks regulates DNA repair.
openaire +1 more source