Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates [PDF]
BMC Biology, 2009 Background Within chromatin, the histone variant H2A.Z plays a role in many diverse nuclear processes including transcription, preventing the spread of heterochromatin and epigenetic transcriptional memory.
Helbing Caren C +11 more
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The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues [PDF]
BMC Evolutionary Biology, 2009 Background The histone H2A family encompasses the greatest number of core histone variants of which the replacement variant H2A.Z is currently one of the most heavily studied.
Ausió Juan +4 more
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H2A.Z: a molecular rheostat for transcriptional control [PDF]
F1000Prime Reports, 2015 The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms.
Boyer, Laurie +2 more
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The histone variant H2A.Z in gene regulation [PDF]
Epigenetics & Chromatin, 2019 The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer.
Benedetto Daniele Giaimo +4 more
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Epigenetic modulation via the C-terminal tail of H2A.Z [PDF]
Nature Communications, 2021 H2A.Z-nucleosomes are present in both euchromatin and heterochromatin and it has proven difficult to interpret their disparate roles in the context of their stability features.
László Imre +24 more
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H3K4me2 orchestrates H2A.Z and Polycomb repressive marks in Arabidopsis [PDF]
Nature CommunicationsThe dimethylation of histone H3 lysine 4 (H3K4me2) plays an important role in developmental phase transitions in plants, such as regeneration from the callus and the initiation of flowering.
Takumi Noyori +6 more
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License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication. [PDF]
BioessaysOrigin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Frisbie V, Bleichert F.
europepmc +2 more sources
Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2 [PDF]
Acta Crystallographica Section D Biological Crystallography, 2013 The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported.
Naoki Horikoshi +11 more
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Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae. [PDF]
PLoS GeneticsChromatin structure and DNA accessibility are partly modulated by the incorporation of histone variants. H2A.Z, encoded by the non-essential HTZ1 gene in S. cerevisiae, is an evolutionarily conserved H2A histone variant that is predominantly incorporated
Hilary T Brewis +2 more
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