Results 221 to 230 of about 12,258 (237)

Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes. [PDF]

open access: yesBiochem J
Ocampo J   +6 more
europepmc   +1 more source

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer. [PDF]

open access: yesNat Commun
Lago S   +13 more
europepmc   +1 more source
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H2A.Z and DNA methylation: irreconcilable differences

Trends in Biochemical Sciences, 2009
DNA methylation state and the composition of the nucleosome core particle influence chromatin structure and, in turn, transcriptional competence. Although it is clear that chromatin remodeling and covalent histone modifications regulate DNA methylation in plants and animals, the role of histone variants in directing DNA methylation, and vice versa, has
Michael S, Kobor, Matthew C, Lorincz
openaire   +2 more sources

Histone Variant H2A.Z Inhibits Transcription in Reconstituted Nucleosomes

Biochemistry, 2010
The existence of histone nonallelic variants has been known for more than 30 years, but only recently have we acquired significant insights into their functions. Nucleosomes containing histone variants are nonrandomly distributed in genomes and may impart different biological functions to the relevant chromatin regions.
Amit, Thakar   +3 more
openaire   +2 more sources

The conserved histone variant H2A.Z illuminates meiotic recombination initiation

Current Genetics, 2018
Meiotic recombination ensures faithful chromosome segregation and confers genetic diversity to gametes, and thus, is a key DNA-templated reaction not only for sexual reproduction, but also evolution. This recombination is initiated by programmed DNA double strand breaks (DSBs), which are mainly formed at recombination hotspots. As meiotic DSB formation
Shintaro, Yamada   +7 more
openaire   +2 more sources

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