The H2A.Z-nucleosome code in mammals: emerging functions [PDF]
Trends in Genetics, 2022 H2A.Z is a histone variant that provides specific structural and docking-side properties to the nucleosome, resulting in diverse and specialised molecular and cellular functions. In this review, we discuss the latest studies uncovering new functional aspects of mammalian H2A.Z in gene transcription, including pausing and elongation of RNA polymerase II
Yolanda Colino-Sanguino +2 more
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Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation
eLife, 2020 The H2A.Z histone variant plays major roles in the control of gene expression. In human, H2A.Z is encoded by two genes expressing two isoforms, H2A.Z.1 and H2A.Z.2 differing by three amino acids.
Assala Lamaa +6 more
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Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions [PDF]
Cells, 2020 The replication independent (RI) histone H2A.Z is one of the more extensively studied variant members of the core histone H2A family, which consists of many replication dependent (RD) members. The protein has been shown to be indispensable for survival, and involved in multiple roles from DNA damage to chromosome segregation, replication, and ...
Manjinder S. Cheema +17 more
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Single Molecule Tools Elucidate H2A.Z Nucleosome Composition [PDF]
Journal of Cell Science, 2012 Although different epigenetic marks correlate with different chromatin states, how they are integrated within single nucleosomes to generate combinatorial signals remains largely unknown. We report the successful implementation of single molecule tools constituting Fluorescence Correlation Spectroscopy (FCS), Pulse Interleave Excitation-based Forster ...
Chen, Jiji +3 more
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Deposition of histone variant H2A.Z within gene bodies regulates responsive genes. [PDF]
PLoS Genetics, 2012 The regulation of eukaryotic chromatin relies on interactions between many epigenetic factors, including histone modifications, DNA methylation, and the incorporation of histone variants.
Devin Coleman-Derr, Daniel Zilberman
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Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction
eLife, 2020 The H2A.Z histone variant, a genome-wide hallmark of permissive chromatin, is enriched near transcription start sites in all eukaryotes. H2A.Z is deposited by the SWR1 chromatin remodeler and evicted by unclear mechanisms.
Anand Ranjan +15 more
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Advanced Science, 2022 Early embryos undergo extensive epigenetic reprogramming to achieve gamete‐to‐embryo transition, which involves the loading and removal of histone variant H2A.Z on chromatin.
Xin Liu +20 more
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H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization [PDF]
Nucleic Acids Research, 2012 The histone variant H2A.Z has been implicated in many biological processes, such as gene regulation and genome stability. Here, we present the identification of H2A.Z.2.2 (Z.2.2), a novel alternatively spliced variant of histone H2A.Z and provide a comprehensive characterization of its expression and chromatin incorporation properties.
C. Bonisch +14 more
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Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes. [PDF]
, 2017 The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing.
Bailey, Emma R +7 more
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Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway
Biology Open, 2021 Elongator dysfunction is increasingly recognized as a contributor to multiple neurodevelopmental and neurodegenerative disorders including familial dysautonomia, intellectual disability, amyotrophic lateral sclerosis, and autism spectrum disorder ...
BreAnna Cameron +9 more
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