SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae [PDF]
, 2011 Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans ...
Anna T. Vetter +13 more
core +9 more sources
TREEOME: A framework for epigenetic and transcriptomic data integration to explore regulatory interactions controlling transcription [PDF]
, 2015 Motivation: Predictive modelling of gene expression is a powerful framework for the in silico exploration of transcriptional regulatory interactions through the integration of high-throughput -omics data.
Budden, David M +2 more
core +2 more sources
PLoS Biology, 2010 H2A.Z is a histone H2A variant conserved from yeast to humans, and is found at 63% of promoters in Saccharomyces cerevisiae. This pattern of localization suggests that H2A.Z is somehow important for gene expression or regulation.
Jeffrey E Halley +4 more
doaj +1 more source
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. [PDF]
PLoS ONE, 2012 The essential histone variant H2A.Z localises to both active and silent chromatin sites. In embryonic stem cells (ESCs), H2A.Z is also reported to co-localise with polycomb repressive complex 2 (PRC2) at developmentally silenced genes.
Robert S Illingworth +4 more
doaj +1 more source
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]
, 2015 Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core +1 more source
A Conserved Function for the H2A.Z C Terminus [PDF]
Journal of Biological Chemistry, 2012 Histone H2A variants generate diversity in chromatin structure and functions, as nucleosomes containing variant H2A histones have altered physical, chemical, and biological properties. H2A.Z is an evolutionarily ancient and highly conserved H2A variant that regulates processes ranging from gene expression to the DNA damage response.
Wratting, Daniel +4 more
openaire +2 more sources
Cell Reports, 2021 Summary: Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival.
Christopher Lowden +15 more
doaj +1 more source
Direct measurement of transcription rates reveals multiple mechanisms for configuration of the Arabidopsis ambient temperature response [PDF]
, 2014 Background Sensing and responding to ambient temperature is important for controlling growth and development of many organisms, in part by regulating mRNA levels.
Costa, Maria J. (Maria João) +4 more
core +1 more source
ΔNp63α represses anti-proliferative genes via H2A.Z deposition [PDF]
Genes & Development, 2012 ΔNp63α is a member of the p53 family of transcription factors that functions as an oncogene in squamous cell carcinomas (SCCs). Because ΔNp63α and p53 bind virtually identical DNA sequence motifs, it has been proposed that ΔNp63α functions as a dominant-negative inhibitor of p53 to promote proliferation and block apoptosis.
Corrie L, Gallant-Behm +7 more
openaire +2 more sources
Coordinated DNA and Histone Dynamics Drive Accurate Histone H2A.Z Exchange [PDF]
Science Advances, 2021 AbstractNucleosomal histone H2A is exchanged for its variant H2A.Z by the SWR1 chromatin remodeler, but the mechanism and timing of histone exchange remain unclear. Here, we quantify DNA and histone dynamics during histone exchange in real-time using a three-color single-molecule FRET assay. We show that SWR1 operates with timed precision to unwrap DNA
Matthew F. Poyton +12 more
openaire +2 more sources