The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization [PDF]
, 2017 The human Cranio Facial Development Protein 1 (Cfdp1) gene maps to chromosome 16q22.2-q22.3 and encodes the CFDP1 protein, which belongs to the evolutionarily conserved Bucentaur (BCNT) family.
Atterrato, Maria Teresa +5 more
core +3 more sources
ΔNp63α Regulates H2A.Z Exchange [PDF]
Cancer Discovery, 2012 Abstract ΔNp63α-dependent SRCAP recruitment and H2A.Z deposition suppress target gene expression.
openaire +1 more source
Cell Death and Disease, 2021 In eukaryotes, histones and their variants are essential for chromatin structure and function; both play important roles in the regulation of gene transcription, as well as the development of tumors.
Yin Yuan +4 more
doaj +1 more source
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer [PDF]
, 2013 Histone variants seem to play a major role in gene expression regulation. In prostate cancer, H2A.Z and its acetylated form are implicated in oncogenes’ upregulation.
Amado, Francisco +8 more
core +2 more sources
Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement.
PLoS Biology, 2019 Chz1 is a specific chaperone for the histone variant H2A.Z in budding yeast. The ternary complex formed by Chz1 and H2A.Z-H2B dimer is the major in vivo substrate of Swi2/snif2-related 1 (SWR1), the ATP-dependent chromatin remodeling enzyme that deposits
Yunyun Wang +10 more
doaj +1 more source
H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs
Cell Reports, 2016 Summary: Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in embryonic stem cells (ESCs) to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood.
Lauren E. Surface +8 more
doaj +1 more source
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate +4 more
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AIMS Bioengineering, 2020 Flavonoid is an important group of plant secondary metabolites. The biosynthesis of this flavonoid group can be precisely regulated by many environmental factors.
Nguyen Hoai Nguyen
doaj +1 more source
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]
, 2015 BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M +5 more
core +2 more sources
Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression [PDF]
, 2020 SUMMARYH2A.Z is a H2A-type histone variant essential for many aspects of cell biology ranging from gene expression to genome stability. From deuterostomes, H2A.Z evolved into two paralogues H2A.Z.1 and H2A.Z.2 that differ by only three amino acids and are encoded by different genes (H2AFZandH2AFVrespectively).
Raquel Sales-Gil +7 more
openaire +1 more source