Results 61 to 70 of about 12,258 (237)
Microbiology Spectrum, 2023 We provide evidence that the Saccharomyces cerevisiae C-terminal region of histone variant H2A.Z can mediate its special function in performing gene regulation by interacting with effector proteins and chaperones.
Hannah Neumann +6 more
openaire +2 more sources
Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +2 more sources
Histone H2A.Z Acetylation Modulates an Essential Charge Patch [PDF]
Molecular Cell, 2001 Histone H2A.Z is structurally and functionally distinct from the major H2As. To understand the function of H2A.Z acetylation, we performed a mutagenic analysis of the six acetylated lysines in the N-terminal tail of Tetrahymena H2A.Z. Tetrahymena cannot survive with arginines at all six sites.
Ren, Qinghu, Gorovsky, Martin A.
openaire +2 more sources
Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus
Cell Reports, 2018 Summary: Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we show that basal H2A.Z occupancy is positively associated with steady ...
Gilda Stefanelli +11 more
doaj +1 more source
BMC Cancer, 2022 Background Intrahepatic cholangiocarcinoma (ICC), originating from the bile ducts, is the second most common primary liver malignancy, and its incidence has recently increased.
Qi Wang +5 more
doaj +1 more source
Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
core +1 more source
Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany [PDF]
, 2020 In June 2019, more than a hundred plant researchers met in Cologne, Germany, for the 6th European Workshop on Plant Chromatin (EWPC). This conference brought together a highly dynamic community of researchers with the common aim to understand how ...
Engelhorn, Julia +5 more
core +1 more source
H2A.Z nucleosomes enriched over active genes are homotypic [PDF]
Nature Structural & Molecular Biology, 2010 Nucleosomes that contain the histone variant H2A.Z are enriched around transcriptional start sites, but the mechanistic basis for this enrichment is unknown. A single octameric nucleosome can contain two H2A.Z histones (homotypic) or one H2A.Z and one canonical H2A (heterotypic).
Weber, Christopher M. +2 more
openaire +2 more sources
PLoS Genetics, 2012 H2A.Z is an essential histone variant that has been implicated to have multiple chromosomal functions. To understand how H2A.Z participates in such diverse activities, we sought to identify downstream effector proteins that are recruited to chromatin via
Ryan Draker +5 more
doaj +1 more source
High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier. [PDF]
, 2019 Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II ...
Brown, Aidan I +9 more
core +2 more sources