Results 131 to 140 of about 16,350 (151)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease. [PDF]

Adv Sci (Weinh)
Chen YH, Zhu RX, Zhang NX, Sun TT, Zhang XW, Zhao YJ, He BY, Yao H, Du RH, Cao L, Zhang WB, Liu WG, Cai Y, Wang C, Hu G, Wei Y, Liu Y, Lu M.   +17 more
europepmc   +1 more source

Mapping cis- and trans-regulatory target genes of human-specific deletions. [PDF]

Nat Commun
Fair T, Pavlovic BJ, Swope D, Castillo OE, Schaefer NK, Pollen AA.   +5 more
europepmc   +1 more source

Comparative multi-omics of the macrophage response to infection with Mycobacterium tuberculosis complex bacteria reveals pathogen-driven epigenomic reprogramming

Hall TJ, Mitermite M, O’Grady JF, Browne JA, McHugo GP, Clark EL, Salavati M, Gordon SV, MacHugh DE.   +8 more
europepmc   +1 more source

SNF5 promotes IL-1β expression via H3K4me1 in atherosclerosis induced by homocysteine

International Journal of Biochemistry and Cell Biology, 2021
Homocysteine (Hcy) is a strong and independent risk factor of atherosclerosis. It can accelerate atherosclerosis through increased production of inflammatory factors, especially interleukin-1 β (IL-1β), while the precise mechanisms remain to be well elucidated.
Yideng Jiang, Yideng Jiang, Anning Yang   +2 more
exaly   +3 more sources

Identification of H3K4me1-associated proteins at mammalian enhancers [PDF]

Nature Genetics, 2017
Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type-specific manner.
Chaochen Wang, Kevin Corbett, Dong Wang   +2 more
exaly   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Is H3K4me1 at enhancers correlative or causative?

Nature Genetics, 2017
H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.
Alvaro Rada-Iglesias, Rada-Iglesias Alvaro   +1 more
exaly   +3 more sources

H3K4me1 recruits DNA repair proteins in plants

Plant Cell
Abstract DNA repair proteins can be recruited by their histone reader domains to specific epigenomic features, with consequences on intragenomic mutation rate variation. Here, we investigated H3K4me1-associated hypomutation in plants.
Gosuke Hayashi, Vladimir Yarov-Yarovoy, Daniela Quiroz   +2 more
exaly   +4 more sources

Enhancer regulation by H3K4me1 methyltransferases MLL3/MLL4

The FASEB Journal, 2022
Enhancers control cell type‐specific gene expression and are marked by H3K4me1. Active enhancers are further marked by H3K27ac. We identified MLL3/MLL4 as major H3K4me1 methyltransferases and CBP/p300 as the H3K27 acetyltransferases in mammalian cells ( EMBO J 2011; eLife 2013 ).
openaire   +1 more source

H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation

Molecular Cell
Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers. KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase activities are largely dispensable for transcription during early embryogenesis in mammals.
Hiroyuki Sasaki, Bing Ren, Naoki Kubo
exaly   +3 more sources

ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes

Molecular Cell, 2016
Histone acetylation, including acetylated H3K14 (H3K14ac), is generally linked to gene activation. Monomethylated histone H3 lysine 4 (H3K4me1), together with other gene-activating marks, denotes active genes. In contrast to usual gene-activating functions of H3K14ac and H3K4me1, we here show that the dual histone modification mark H3K4me1-H3K14ac is ...
Jie Lv, Xiaobing Shi, Haitao Li
exaly   +3 more sources