Results 21 to 30 of about 34,324 (178)

Randomized, double-blind, multi-center, phase III clinical trial to evaluate the immunogenicity and safety of MG1109 (egg-based pre-pandemic influenza A/H5N1 vaccine) in healthy adults

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Considering the pandemic potential of avian influenza A/H5N1, development of an effective and well-tolerated vaccine is an essential part of pandemic preparedness plans.
Joon Young Song   +9 more
doaj   +1 more source

Purification and immunogenicity of hemagglutinin from highly pathogenic avian influenza virus H5N1 expressed in Nicotiana benthamiana

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Highly pathogenic avian influenza (HPAI) H5N1 is an ongoing global health concern due to its severe sporadic outbreaks in Asia, Africa and Europe, which poses a potential pandemic threat.
Teen-Lee Pua   +11 more
doaj   +1 more source

H5N1: A Cautionary Tale [PDF]

open access: yesFrontiers in Public Health, 2014
The history of the research with the highly pathogenic avian influenza virus H5N1 and the publication of the results of that research is reminiscent of the Buddhist “Parable of the Blind Men and the Elephant.” In the parable, the Buddha relates a story of a raja who, when confronted with disputatious scholars, gathered blind men and presented each man ...
openaire   +3 more sources

analysis of antiviral immune response against avian influenza virus in chicken tracheal epithelial cells [PDF]

open access: yesAnimal Bioscience
Objective Avian influenza virus (AIV) infections first affect the respiratory tract of chickens. The epithelial cells activate the host immune system, which leads to the induction of immune-related genes and the production of antiviral molecules against ...
Jubi Heo   +4 more
doaj   +1 more source

A comparison of clinical and epidemiological characteristics of fatal human infections with H5N1 and human influenza viruses in Thailand, 2004-2006. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: The National Avian Influenza Surveillance (NAIS) system detected human H5N1 cases in Thailand from 2004-2006. Using NAIS data, we identified risk factors for death among H5N1 cases and described differences between H5N1 and human (seasonal ...
Vivek Shinde   +8 more
doaj   +1 more source

Highly Pathogenic Avian Flu A(H5N1): State of Affairs in 2009–2012 and Forecast of Its Pandemic Potential

open access: yesПроблемы особо опасных инфекций, 2013
Avian flu is an infectious viral disease in birds that still retains its positions in some parts of Asia and Africa. This review contains summarization and analysis of facts regarding the current situation on highly pathogenic avian flu A-type subtype ...
A. M. Shestopalov   +5 more
doaj   +1 more source

Differential Impact of Specific Amino Acid Residues on the Characteristics of Avian Influenza Viruses in Mammalian Systems

open access: yesPathogens, 2022
Avian influenza virus (AIV) H9N2 was declared to be endemic in birds of the Middle East, in particular in Egypt, with multiple cases of human infections.
Dayly Mashaal   +8 more
doaj   +1 more source

H5N1 outbreaks and enzootic influenza

open access: yesBiodiversity, 2006
Ongoing outbreaks of H5N1 avian influenza in migratory waterfowl, domestic poultry, and humans in Asia during the summer of 2005 present a continuing, protean pandemic threat. We review the zoonotic source of highly pathogenic H5N1 viruses and their genesis from their natural reservoirs. The acquisition of novel traits, including lethality to waterfowl,
Guan, Y, Webster, RG, Peiris, M, Chen, H
openaire   +4 more sources

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

open access: yesAdvanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li   +5 more
wiley   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

open access: yesAnimal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary   +7 more
wiley   +1 more source

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