Results 31 to 40 of about 67,829 (223)

Randomized, double-blind, multi-center, phase III clinical trial to evaluate the immunogenicity and safety of MG1109 (egg-based pre-pandemic influenza A/H5N1 vaccine) in healthy adults

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Considering the pandemic potential of avian influenza A/H5N1, development of an effective and well-tolerated vaccine is an essential part of pandemic preparedness plans.
Joon Young Song   +9 more
doaj   +1 more source

Purification and immunogenicity of hemagglutinin from highly pathogenic avian influenza virus H5N1 expressed in Nicotiana benthamiana

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Highly pathogenic avian influenza (HPAI) H5N1 is an ongoing global health concern due to its severe sporadic outbreaks in Asia, Africa and Europe, which poses a potential pandemic threat.
Teen-Lee Pua   +11 more
doaj   +1 more source

Prediction and prevention of the next pandemic zoonosis. [PDF]

open access: yes, 2012
Most pandemics--eg, HIV/AIDS, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes.
Carroll, Dennis   +8 more
core   +1 more source

H5N1: A Cautionary Tale [PDF]

open access: yesFrontiers in Public Health, 2014
The history of the research with the highly pathogenic avian influenza virus H5N1 and the publication of the results of that research is reminiscent of the Buddhist “Parable of the Blind Men and the Elephant.” In the parable, the Buddha relates a story of a raja who, when confronted with disputatious scholars, gathered blind men and presented each man ...
openaire   +3 more sources

analysis of antiviral immune response against avian influenza virus in chicken tracheal epithelial cells [PDF]

open access: yesAnimal Bioscience
Objective Avian influenza virus (AIV) infections first affect the respiratory tract of chickens. The epithelial cells activate the host immune system, which leads to the induction of immune-related genes and the production of antiviral molecules against ...
Jubi Heo   +4 more
doaj   +1 more source

A comparison of clinical and epidemiological characteristics of fatal human infections with H5N1 and human influenza viruses in Thailand, 2004-2006. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: The National Avian Influenza Surveillance (NAIS) system detected human H5N1 cases in Thailand from 2004-2006. Using NAIS data, we identified risk factors for death among H5N1 cases and described differences between H5N1 and human (seasonal ...
Vivek Shinde   +8 more
doaj   +1 more source

Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro [PDF]

open access: yes, 2012
Background: The ligand-activated transcription factor, peroxisome-proliferator-activated receptor gamma (PPARγ), has been shown to play an essential role in immunosuppression during sepsis.
Brüne, Bernhard   +6 more
core   +1 more source

Differential Impact of Specific Amino Acid Residues on the Characteristics of Avian Influenza Viruses in Mammalian Systems

open access: yesPathogens, 2022
Avian influenza virus (AIV) H9N2 was declared to be endemic in birds of the Middle East, in particular in Egypt, with multiple cases of human infections.
Dayly Mashaal   +8 more
doaj   +1 more source

Highly Pathogenic Avian Flu A(H5N1): State of Affairs in 2009–2012 and Forecast of Its Pandemic Potential

open access: yesПроблемы особо опасных инфекций, 2013
Avian flu is an infectious viral disease in birds that still retains its positions in some parts of Asia and Africa. This review contains summarization and analysis of facts regarding the current situation on highly pathogenic avian flu A-type subtype ...
A. M. Shestopalov   +5 more
doaj   +1 more source

H5N1 outbreaks and enzootic influenza

open access: yesBiodiversity, 2006
Ongoing outbreaks of H5N1 avian influenza in migratory waterfowl, domestic poultry, and humans in Asia during the summer of 2005 present a continuing, protean pandemic threat. We review the zoonotic source of highly pathogenic H5N1 viruses and their genesis from their natural reservoirs. The acquisition of novel traits, including lethality to waterfowl,
Guan, Y, Webster, RG, Peiris, M, Chen, H
openaire   +4 more sources

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