Results 51 to 60 of about 3,797 (217)

Phosphorylation of S-S-S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses. [PDF]

Adv Sci (Weinh)
The phosphorylation of S‐S‐S motif on influenza virus NEP is required for NEP interaction with CRM1 thereby mediating vRNP nuclear export, which can be regulated by the kinase ATM and CK2. Impairment of phosphorylation on NEP S‐S‐S motif significantly suppresses virus replication and reduces the virulence in mice.
Liu X, Yang C, Lin X, Sun X, Chen H, Zhang Q, Jin M.   +6 more
europepmc   +2 more sources

Continuous Reassortment of Clade 2.3.4.4 H5N6 Highly Pathogenetic Avian Influenza Viruses Demonstrating High Risk to Public Health

Pathogens, 2020
Since it firstly emerged in China in 2013, clade 2.3.4.4 H5N6 highly pathogenic avian influenza viruses (HPAIVs) has rapidly replaced predominant H5N1 to become the dominant H5 subtype in China, especially in ducks.
Huanan Li, Qian Li, Bo Li, Yang Guo, Jinchao Xing, Qiang Xu, Lele Liu, Jiahao Zhang, Wenbao Qi, Weixin Jia, Ming Liao   +10 more
doaj   +1 more source

Exploring the global immune landscape of peripheral blood mononuclear cells in H5N6-infected patient with single-cell transcriptomics

BMC Medical Genomics, 2023
Background Avian influenza viruses (AIV), particularly H5N6, have risen in infection frequency, prompting major concerns. Single-cell RNA sequencing (scRNA-seq) can illustrate the immune cell landscape present in the peripheral circulation of influenza ...
Jiamin Gao, Jing Wei, Simei Qin, Sheng Liu, Shuangyan Mo, Qian Long, Shiji Tan, Ning Lu, Zhouhua Xie, Jianyan Lin   +9 more
doaj   +1 more source

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) [PDF]

, 2018
Highly pathogenic avian influenza (HPAI) H5N1 virus has been circulating in Vietnam since 2003, while outbreaks of HPAI H5N6 virus are more recent, having only been reported since 2014. Although the spatial distribution of H5N1 outbreaks and risk factors
Azzouz, Cappelletti, Chen, Cirulli, Filali, Gill, Horiike, Kaneb, Kawazoe, Kondori, Konno, Lee, Li, Lincecum, Martinez, Mitchell, Mothet, Mothet, Murtas, Nelson, Neumann, Panatier, Paul, Paul, Sasabe, Sasabe, Scott, Sharp, Taylor, Traynor, Tudor, Vincelette, Wang, Wolosker, Wu, Yang   +35 more
core   +3 more sources

Amino Acid Substitutions Associated with Avian H5N6 Influenza A Virus Adaptation to Mice

Frontiers in Microbiology, 2017
At least 15 cases of human beings infected with H5N6 have been reported since 2014, of which at least nine were fatal. The highly pathogenic avian H5N6 influenza virus may pose a serious threat to both public health and the poultry industry. However, the
Chunmao Zhang, Zongzheng Zhao, Zhendong Guo, Jiajie Zhang, Jiaming Li, Yifei Yang, Shaoxia Lu, Zhongyi Wang, Min Zhi, Yingying Fu, Xiaoyu Yang, Lina Liu, Yi Zhang, Yuping Hua, Linna Liu, Hongliang Chai, Jun Qian   +16 more
doaj   +1 more source

Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China

Emerging Infectious Diseases, 2022
The recent rise in the frequency of influenza A(H5N6) infections in China has raised serious concerns about whether the risk for human infection has increased.
Wenfei Zhu, Xiyan Li, Jie Dong, Hong Bo, Jia Liu, Jiaying Yang, Ye Zhang, Hejiang Wei, Weijuan Huang, Xiang Zhao, Tao Chen, Jing Yang, Zi Li, Xiaoxu Zeng, Chao Li, Jing Tang, Li Xin, Rongbao Gao, Liqi Liu, Min Tan, Yuelong Shu, Lei Yang, Dayan Wang   +22 more
doaj   +1 more source

Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 2.1.3.2a, 2.2.1, and 2.3.4 during 2013-2014. [PDF]

, 2015
AIM: The A/goose/Guangdong/1/96-like hemagglutinin (HA) genes of highly pathogenic avian influenza (HPAI) A(H5) viruses have continued to rapidly evolve since the most recent update to the H5 clade nomenclature by the WHO/OIE/FAO H5N1 Evolution Working ...
Donis, Ruben O, Smith, Gavin JD, World Health Organization/World Organisation for Animal Health/Food and Agriculture Organization (WHO/OIE/FAO) H5 Evolution Working Group   +2 more
core   +2 more sources

Human infections with novel reassortant H5N6 avian influenza viruses in China [PDF]

Emerging Microbes & Infections, 2017
Emerging Microbes & Infections (2017) 6, e50; doi:10.1038/emi.2017.38; published online 7 June ...
Ye Zhang, Minmei Chen, Yiwei Huang, Wenfei Zhu, Lei Yang, Lidong Gao, Xiaodan Li, Fuyin Bi, Chaoyang Huang, Ning Kang, Hengjiao Zhang, Zi Li, Hong Bo, Dayan Wang, Yuelong Shu   +14 more
openaire   +3 more sources

Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets [PDF]

, 2016
Since May 2014, highly pathogenic avian influenza H5N6 virus has been reported to cause six severe human infections three of which were fatal. The biological properties of this subtype, in particular its relative pathogenicity and transmissibility in ...
Chang, Kin-Chow, Gao, Weihua, Hu, Jiao, Huang, Yinhua, Li, Chong, Liu, Jinhua, Liu, Litao, Liu, Xiufan, Pu, Juan, Sun, Honglei, Sun, Yipeng, Wei, Yandi, Xu, Guanlong, Zhang, Xuxiao   +13 more
core   +1 more source

Serosurveillance of avian influenza A/H5N6 virus infection in poultry farmers, Gyeonggi Province, Republic of Korea, 2016–2017

International Journal of Infectious Diseases, 2018
Objectives: Between November 20, 2016 and April 17, 2017, outbreaks of highly pathogenic avian influenza (HPAI) A/H5N6 occurred on poultry farms in Gyeonggi Province in the Republic of Korea.
Sukhyun Ryu, Chi-Kyeong Kim, Kisoon Kim, Sang Hee Woo, Byung Chul Chun   +4 more
doaj   +1 more source